Lipase-based MIL-100(Fe) biocomposites as chiral stationary phase for high-efficiency capillary electrochromatographic enantioseparation

Choi, Dong Min; Xu, Helong; Baeck, Sung Hyeon; Row, Kyung Ho; Tang, Weiyang

doi:10.1007/s00604-023-05647-9

Cited by 6 publications

(6 citation statements)

References 37 publications

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“…Note that the separation resolution of six chiral drugs (i.e., chloroquine (CHQ), hydroxychloroquine (HCQ), nefopam (NEF), clenbuterol (CLE), amlodipine (AML), and hydroxyzine (HXY)) using the pepsin-ZIF-8-poly(GMA- co -EDMA) column demonstrated remarkable improvement in the resolution (i.e., CHQ: 0.45→1.97; HCQ: 0.34→2.50; NEF: 0.27→0.81; CLE: 0→0.81; AML: 0.1→0.72; HXY: 0.39→1.43). Similarly, Sun et al [ 170 ] used lipase immobilized MIL-100 (Fe) biocomposites as a chiral stationary phase for capillary electrochromatographic enantioseparation. The performance of the porous column was evaluated by enantioseparating amino acid enantiomers with a high resolution of over 2.0.…”

Section: Liquid Separationmentioning

confidence: 99%

Engineering Metal-Organic-Framework (MOF)-Based Membranes for Gas and Liquid Separation

Duan

Li²,

Shen

et al. 2023

Membranes

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Separation is one of the most energy-intensive processes in the chemical industry, and membrane-based separation technology contributes significantly to energy conservation and emission reduction. Additionally, metal-organic framework (MOF) materials have been widely investigated and have been found to have enormous potential in membrane separation due to their uniform pore size and high designability. Notably, pure MOF films and MOF mixed matrix membranes (MMMs) are the core of the “next generation” MOF materials. However, there are some tough issues with MOF-based membranes that affect separation performance. For pure MOF membranes, problems such as framework flexibility, defects, and grain orientation need to be addressed. Meanwhile, there still exist bottlenecks for MMMs such as MOF aggregation, plasticization and aging of the polymer matrix, poor interface compatibility, etc. Herein, corresponding methods are introduced to solve these problems, including inhibiting framework flexibility, regulating synthesis conditions, and enhancing the interaction between MOF and substrate. A series of high-quality MOF-based membranes have been obtained based on these techniques. Overall, these membranes revealed desired separation performance in both gas separation (e.g., CO2, H2, and olefin/paraffin) and liquid separation (e.g., water purification, organic solvent nanofiltration, and chiral separation).

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Section: Liquid Separationmentioning

confidence: 99%

Engineering Metal-Organic-Framework (MOF)-Based Membranes for Gas and Liquid Separation

Duan

Li²,

Shen

et al. 2023

Membranes

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show abstract

“…The pharmaceutical and chemical industries have witnessed a significant demand for single enantiomers with the advent of chiral drugs. Efficient enantioseparation holds critical importance and meaning in the pharmaceutical and agrochemical industries (Sun, Choi, et al., 2023). Several instruments have been utilized for the purpose of enantioseparation.…”

Section: Practical Applications Of Mofs‐lipase Compositesmentioning

confidence: 99%

“…Furthermore, the utilization of the lipase@MIL‐100(Fe) column exhibited a broad spectrum of applicability toward diverse racemic compounds. The immobilization of lipase@ MIL‐100(Fe) composites in a porous column resulted in a high resolution of over 2 for amino acid enantiomers (Sun, Choi, et al., 2023).…”

Section: Practical Applications Of Mofs‐lipase Compositesmentioning

confidence: 99%

“…The pharmaceutical and chemical industries have witnessed a significant demand for single enantiomers with the advent of chiral drugs. Efficient enantioseparation holds critical importance and meaning in the pharmaceutical and agrochemical industries (Sun, Choi, et al, 2023). Several Subsequently, the chiral porous column was fabricated utilizing lipase@MIL-100(Fe) biocomposites through one-pot polymerization, employing methanol and dimethyl sulfoxide as the porogenic solvents.…”

Section: Food Industry and Othermentioning

confidence: 99%

“…The immobilization of lipase@ MIL-100(Fe) composites in a porous column resulted in a high resolution of over 2 for amino acid enantiomers (Sun, Choi, et al, 2023).…”

Section: Food Industry and Othermentioning

confidence: 99%

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Recent trends in metal‐organic frameworks mediated lipase immobilization: A state‐of‐the‐art review

Patil,

Dong,

Usman

et al. 2023

Food Safety and Health

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Immobilized lipase is a powerful biocatalytic system with numerous applications in industries, particularly in the energy, pharmaceutical, cosmetic, and food industries. Reusability, simple recovery, and high chemical and thermal stability make it an attractive alternative to traditional chemical catalysts in industrial applications. Novel methods and support materials for immobilizing lipases have recently attracted much attention. Metal‐organic frameworks (MOFs) are a promising class of materials for enzyme immobilization carriers due to their appealing features, including a high specific surface area, high specific porosity, a stable framework structure, and a wide variety of functional sites. Due to the protection provided to enzymes by MOFs, several reported MOFs‐lipase composites display exceptional catalytic characteristics relative to free lipases. This includes increased enzyme efficiency, stability, selectivity, and recyclability. Herein, we summarize an updated review of the most recent advances in MOFs immobilizing lipases. This review sheds light on the numerous aspects of lipase‐MOF immobilization, with special emphasis on different techniques of designing lipase‐MOF platforms and the advantages of lipase‐MOF composites. Subsequently, molecular simulation approaches in lipase‐MOF immobilization are briefly introduced. Moreover, practical applications of MOFs‐lipase composites have been outlined. Finally, potential limitations and future directions for MOFs‐lipase immobilization research are highlighted.

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Construction and Application of a Pepsin‐Functionalized Covalent Organic Framework with Prominent Chiral Recognition Ability

Zhang,

Liu,

et al. 2024

Chemistry A European J

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The stable Pepsin@covalent organic framework (Pepsin@COF) were constructed base on matching COF pore diameter to pepsin dimension. It exhibits excellent chiral recognition capabilities (e.e.% up to 62.63%) and potential for enantioseparation. Furthermore, a positive correlation between the immobilized enzyme activity and chiral recognition was revealed, offering insights for the design of biocatalytic nanosystems in chiral separation.

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Lipase-based MIL-100(Fe) biocomposites as chiral stationary phase for high-efficiency capillary electrochromatographic enantioseparation

Cited by 6 publications

References 37 publications

Engineering Metal-Organic-Framework (MOF)-Based Membranes for Gas and Liquid Separation

Engineering Metal-Organic-Framework (MOF)-Based Membranes for Gas and Liquid Separation

Recent trends in metal‐organic frameworks mediated lipase immobilization: A state‐of‐the‐art review

Construction and Application of a Pepsin‐Functionalized Covalent Organic Framework with Prominent Chiral Recognition Ability

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