Enantioselective Voltammetric Sensors on the Basis of Chiral Materials

Maistrenko, V. N.; Zilberg, R. A.

doi:10.1134/s1061934820120102

Cited by 20 publications

(9 citation statements)

References 154 publications

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“…CV is the most widely used electroanalytical technique for solid electrolytes [292,293]. In one stage of the cycle, the oxidized form is reduced, and in the other, it is reoxidized to its original form.…”

Section: Nps Based On Voltammetric Sensorsmentioning

confidence: 99%

Enantioseparation/Recognition based on nano techniques/materials

Tarigh

2023

J of Separation Science

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Enantiomers show different behaviors in interaction with the chiral environment. Due to their identical chemical structure and their wide application in various industries, such as agriculture, medicine, pesticide, food, and so forth, their separation is of great importance. Today, the term "nano" is frequently encountered in all fields. Technology and measuring devices are moving towards miniaturization, and the usage of nanomaterials in all sectors is expanding substantially. Given that scientists have recently attempted to apply miniaturized techniques known as nano-liquid chromatography/capillary-liquid chromatography, which were originally accomplished in 1988, as well as the widespread usage of nanomaterials for chiral resolution (back in 1989), this comprehensive study was developed. Searching the terms "nano" and "enantiomer separation" on scientific websites such as Scopus, Google Scholar, and Web of Science yields articles that either use miniaturized instruments or apply nanomaterials as chiral selectors with a variety of chemical and electrochemical detection techniques, which are discussed in this article.

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Section: Nps Based On Voltammetric Sensorsmentioning

confidence: 99%

Enantioseparation/Recognition based on nano techniques/materials

Tarigh

2023

J of Separation Science

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“…Most commonly used as chiral selectors are inclusion complexes, 7 molecularly imprinted polymers, 8,9 elements of living systems and their analogs, 10 2D-and 3D-materials based on chiral supramolecular assemblies, 11,12 self-assembled systems, 13 metal-organic framework structures with chiral nanosized pores, 14,15 chiral metal materials, 16 crystalline mesoporous and macroporous nanomaterials with hierarchical chirality, 17 as well as other selectors based on chiral organic and inorganic compounds immobilized on the electrode surface. [18][19][20] However, the sensor layer obtained by simple application of chiral compound to the electrode is often unstable over time, mechanically fragile, and not sensitive enough to the analyte. One of the options for improving its characteristics can be the use of a combination of chiral selectors and carbon nanomaterials such as carbon nanotubes, 21,22 reduced graphene oxide, 23,24 and carbon black.…”

Section: Introductionmentioning

confidence: 99%

Enantioselective voltammetric sensor based on mesoporous graphitized carbon black Carbopack X and fulvene derivative

et al. 2023

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For medicine and pharmaceuticals, the problem of determining and recognizing the enantiomers of biologically active compounds is an actual issue because the enantiomers of the same substance can have different effects on living organisms. This paper describes the development of an enantioselective voltammetric sensor (EVS) based on a glassy carbon electrode (GCE) modified with mesoporous graphitized carbon black Carbopack X (CpX) and a fulvene derivative (1S,4R)‐2‐cyclopenta‐2,4‐dien‐1‐ylidene‐1‐isopropyl‐4‐methylcyclohexane (CpIPMC) for recognition and determination of tryptophan (Trp) enantiomers. Synthesized CpIPMC was characterized by 1H and 13C nuclear magnetic resonance (NMR), chromatography–mass spectrometry, and polarimetry. The proposed sensor platform was studied by Fourier‐transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). Using the square‐wave voltammetry (SWV), it was established that the developed sensor is an effective chiral platform for the quantitative determination of Trp enantiomers, including in a mixture and in biological fluids like urine and blood plasma, with adequate precision and recovery ranged from 96% to 101%.

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“…[6][7][8][9][10][11][12][13] In combination with chiral electrodes, this method can be applied not only for usual analyses but also for discrimination of drug enantiomers in various media. [14][15][16][17][18][19] It is well known that a chiral modifier is the key component for building an electrode's chiral surface for creating high enantioselectivity (ϑ) for selected analytes. 19 The majority of methods (except for molecular imprinting [20][21][22][23][24][25][26] ) use one or more chiral components [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] as modifiers for building a chiral layer on the electrode surface (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

“…Voltammetry is a low‐cost modern express analytical method 1–5 for the quantitative and qualitative analysis of a wide range of drugs 6–13 . In combination with chiral electrodes, this method can be applied not only for usual analyses but also for discrimination of drug enantiomers in various media 14–19 . It is well known that a chiral modifier is the key component for building an electrode's chiral surface for creating high enantioselectivity (ϑ) for selected analytes 19 …”

Section: Introductionmentioning

confidence: 99%

Rational design of highly enantioselective composite voltammetric sensors using a computationally predicted chiral modifier

et al. 2022

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The use of chiral modifiers is among the simplest and most popular strategies for synthesizing enantioselective voltammetric sensors that are applied for the analysis and discrimination of enantiomerical drugs in various media. The type and structure of the chiral modifier are the key factors for the creation of enantioselectivity to a specified analyte. We suggest a novel approach to the prediction of the quality of a chiral modifier for preparing highly enantioselective sensors. The suggested approach is based on the molecular mechanics modeling of the adsorption of analyte enantiomers on chiral modifiers and on the comparison of the corresponding adsorption energies (ΔEads). The efficiency of our approach is demonstrated using the example of cyclodextrins and chiral single‐wall carbon nanotubes as chiral modifiers, and a wide range of chiral analytes. We found that the experimental enantioselectivity (ϑexp) measured using voltammetry linearly correlates with ΔEads. The suggested approach also showed good predictive power in application to enantioselective chromatography, which further validates its general applicability.

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Enantioselective Voltammetric Sensors on the Basis of Chiral Materials

Cited by 20 publications

References 154 publications

Enantioseparation/Recognition based on nano techniques/materials

Enantioseparation/Recognition based on nano techniques/materials

Enantioselective voltammetric sensor based on mesoporous graphitized carbon black Carbopack X and fulvene derivative

Rational design of highly enantioselective composite voltammetric sensors using a computationally predicted chiral modifier

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