“…[12] Additionally to fermentation, [9] a variety of synthetic approaches to 1 have been developed [13][14][15][16][17][18] with the first total synthesis reported in 2003 by Morken. [19] Particularly, the stereoselective formation of the polyketide subunit, that is, the C3-C11 fragment in 1, has been intensively investigated. For example, Morken reported a catalytic reductive aldol reaction, Myers' alkylation, Negishi cross-coupling, and catalytic asymmetric hydrogenation as key steps, [19] whereas a sequence of lipase-catalyzed desymmetrization of meso-2,4-dimethyl-1,5-pentanediol, 1,2-addition of lithium acetylide, carboalumination, and catalytic hydrogenation was used by Omura.…”