Enantioselective Synthesis of Phenyl-ethanolamines Through Application of Chiral Sulfoxide

Abstract

Efficient enantioselective synthesis of (R)-and (S)-enantiomers of 2-(tertbutylamino)-1-(p-methoxyphenyl)-ethanol has been achieved in high enantiomeric excess by using asymmetric sulfoxide as a chiral auxiliary. The present synthetic approach was further extended to the asymmetric synthesis of (R)-salbutamol.