Enantioselective Synthesis Mediated by Chiral Crystal of Achiral Hippuric Acid in Conjunction with Asymmetric Autocatalysis.

Abstract

Enantioselective syntheses O 0031Enantioselective Synthesis Mediated by Chiral Crystal of Achiral Hippuric Acid in Conjunction with Asymmetric Autocatalysis. -Enantiomorphous crystals obtained from methanol solutions of achiral hippuric acid (N-benzoylglycine) by slow evaporation are used successfully as chiral inducers in enantioselective synthesis. In combination with asymmetric autocatalysis the products are produced with high enantioselectivities. -(KAWASAKI, T.; SUZUKI, K.; HATASE, K.; OTSUKA, M.; KOSHIMA, H.; SOAI*, K.; Chem.

Experimental aspects of solid state circular dichroism

“…These simple rules apply to UV-vis CD experiments, while in the IR range there is no way to increase the solid angle collecting geometry given the small surface of the detectors, but in this region scattering artifacts are much lower. Properly obtained Nujol mulls from randomly oriented particulate systems allow, in quite a few instances, direct comparison between solid state and solution spectra and several examples have been published in the UV-vis [26][27][28][29] and IR field. 30 An unusual application of solid state CD in Nujol mulls has been reported under high pressure, 31 these experiments are however very challenging due to the potential induced artifacts.…”