Experimental aspects of solid state circular dichroism

Abstract

The interest of circular dichroism in the solid state is stimulated by several needs, such as the desire to get solvent free spectra, the insolubility of the sample or the intrinsic process in which the sample itself is prepared or manipulated. We approach the argument on the basis of the sampling technique, since each different case calls for specific care in getting proper results.

Solid‐state Circular Dichroism and Hydrogen Bonding, Part 2: The Case of Hypothemycin Re‐investigated

“…40 In the most popular application of CD for the assignment of absolute configurations of organic compounds, one needs to take into account the whole conformational manifold present in solution. 7,8 In the last few years, we have applied the aforementioned method, designated as the solid-state CD/ TDDFT (time dependent density functional theory) approach (because TDDFT calculations were mainly employed), 41 to establish the absolute configuration of several natural products, mostly secondary metabolites from fungi. When quantummechanical CD calculations are employed, a preliminary assessment of the conformational ensemble is necessary, then the calculation must be run on every relevant structure, which may be very computationally demanding especially for large and flexible molecules.…”

Association of biotin with silver (I) in solution: a circular dichroism study

“…The mull measurements followed the protocol suggested in the literature. 20,28 The samples were rotated around the light propagation axis at different angles and the spectra were obtained from front and back sides of the cells at different concentrations and thickness. In all the cases, the spectral pattern was the same.…”

Circular Dichroism Spectroscopy Study of Crystalline‐to‐Amorphous Transformation in Chiral Platinum(II) Complexes

“…5,8,26,27 Five samples were prepared and measured under the same conditions to avoid artifacts. Solid-State ECD spectra were recorded on a Jasco J-810 spectropolarimeter.…”

“…1,2 Present CD measurements are available in both the UV-visible and infrared (especially mid-infrared) regions. 4,8 Second, the interpretation of solid-state CD spectra is quite difficult due to the complexity and large demand for computational resources. 3 As compared to the numerous reports on solution CD spectra, the investigations of solid-state CD spectra are relatively sparse in the literature.…”