Enantioselective Henry reaction catalyzed with copper(II)–iminopyridine complexes

Copper complexes bearing methylthiophenyl and methylfuranyl derivatives of (R,R)-1,2-diaminocyclohexane: X-ray structures and catalytic exploitation in Henry reaction

“…Then nitromethane (0.50 mL, 20 mmol) and benzaldehyde (0.50 mL, 10 mmol) were added followed by addition of 3.0 mol% or 5.0 mol% of iPr 2 Net as a cocatalyst owing to its good activity. 25,26 Similarly 10 mol% of the diacetato-copper catalysts were obtained in situ by treating dichloro-complexes with Ag(OAc) in IPA and the resultatnt solution was applied to Henry reaction under aforementioned reaction conditions. Reactions were monitored by TLC.…”

Synthesis and structures of copper complexes bearing unsymmetric derivatives of (R,R)‐1,2‐diaminocyclohexane: An efficient catalyst for asymmetric Henry reaction

“…The resultant solution was applied to the Henry reaction. Then, nitromethane (0.53 ml, 10 mmol) and benzaldehyde or 3‐phenylpropanal (5.0 mmol) were added followed by the addition of 10.0 mol% of N , N ‐diisopropylethylamine ( i Pr 2 NEt) as a co‐catalyst due to its good activity at −20°C . After stirring for a specified time, reactions were quenched with 1.0 ml of 1 N HCl solution and then evaporated.…”

Salicylaldimine based copper (II) complex-potential catalyst for asymmetric Henry reaction

“…H 2 O can be explained by taking the mechanistic pathway proposed by J.R. Pedro et al 13 for their catalyst, which has almost similar structural environment as that of ligand 2b With the optimised reaction conditions in hand, the scope of the reaction was explored by screening the catalytic system for the asymmetric Henry reaction of various substituted aldehydes and nitromethane ( Table 2). The yield of all the nitroaldols was quantitative.…”