Enantioselective cross-dehydrogenative coupling enabled by organocatalysis

Abstract

Oxidative cross-dehydrogenative coupling (CDC) reactions offer an attractive fashion for the direct formation of C-C and C-X (X = heteroatom) bonds because of no need of prefunctionalization of substrates. Due...

Iodine-enabled organoelectrocatalysis: enantioselective cross dehydrogenative coupling of sulfides and aldehydes

“…7 This method is very effective for α-branched aldehydes but also requires DDQ or other stoichiometric oxidants. The direct dehydrogenative C-H/S-H crosscoupling is the most attractive and environmentally benign approach to construct chiral α-sulfenylated aldehydes 8 (Scheme 1c). Unfortunately, a rapid and effective enantioselective method using unmodified thiols is less developed.…”