Enantioselective analysis in complex matrices using capillary electrophoresis-mass spectrometry: A case study of the botanical drug Corydalis Rhizoma

Yan, Binjun; Huang, Zi‐Ao; Yahaya, Noorfatimah; Chen, David D. Y.

doi:10.1016/j.jchromb.2020.122216

Cited by 12 publications

(14 citation statements)

References 24 publications

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“…The sensitivity enhancement increased up to 2424-fold comparing to CZE [18]. Table 2 [93,[126][127][128][129][130][131][132][133][134][135][136][137] describes a list of applications of CE for pharmaceutical and related biochemical substances.…”

Section: Selected Applications In the Pharmaceutical And Related Bioc...mentioning

confidence: 99%

Sensitivity enhancement in capillary electrophoresis and their applications for analyses of pharmaceutical and related biochemical substances

Suntornsuk

Anurukvorakun

2022

Electrophoresis

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This review aims to illustrate sensitivity enhancement methods in capillary electrophoresis (CE) and their applications for pharmaceutical and related biochemical substance analyses. The first two parts of the article describe the introduction and principle of CE. The main part focuses on strategies for sensitivity improvement in CE including detector and capillary technologies and preconcentration techniques. Applications of these techniques for pharmaceutical and biomedical substance analyses are surveyed during the years 2018-2021.

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Section: Selected Applications In the Pharmaceutical And Related Bioc...mentioning

confidence: 99%

Sensitivity enhancement in capillary electrophoresis and their applications for analyses of pharmaceutical and related biochemical substances

Suntornsuk

Anurukvorakun

2022

Electrophoresis

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“…In this review period, only one derivatized CD, such as 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), was evaluated as a chiral selector in EKC-MS in three separate reports using the PFT approach [33][34][35]. Yan et al showed the simultaneous enantioselective analysis of dl-tetrahydropalmatine and (RS)-tetrahydroberberine (canadine) in Corydalis Rhizoma extract using the flow-through micro vial CE-MS interface [33]. Although the structures of tetrahydropalmatine and canadine are similar, the concentration of HP-β-CD affected their chiral separations differently.…”

Section: -Monomentioning

confidence: 99%

“…Two studies were reported on plant stereospecific activities by chiral CE-MS [28,33]. To study the bioactivities of jasmonic acid (JA), the EKC-MS/MS using polybrene dextrancoated capillary and PFT was successfully developed for the enantioseparation of racemic JA in the first report [28].…”

Section: Plants and Plant Extractsmentioning

confidence: 99%

Capillary Electrophoresis Mass Spectrometry: Developments and Applications for Enantioselective Analysis from 2011–2020

Shamsi

Akter

2022

Molecules

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It is now more than 25 years since the first report of enantioselective analysis by capillary electrophoresis-mass spectrometry (CE-MS) appeared. This article reviews the power of chiral CE-MS in resolving issues on the use of chiral selector incompatibility with MS and poor detectability encountered for chiral compounds by UV detection. The review begins with the general principles, requirements, and critical aspects of chiral CE-MS instrumentation. Next, the review provides a survey of MS-compatible chiral selectors (CSs) reported during the past decade, and the key achievements encountered in the time period using these CSs. Within the context of the strategies used to combine CE and MS, special attention is paid to the approaches that feature partial filling technique, counter-migration techniques, and direct use of CS, such as molecular micelles. In particular, the development and application of moving and fixed CS for EKC-MS, MEKC-MS, and CEC-MS demonstrate how various chiral compounds analyses were solved in a simple and elegant way during the 2010–2020 review period. The most noteworthy applications in the determination of chiral compounds are critically examined. The operating analytical conditions are detailed in the Tables, and the authors provide commentary on future trends of chiral separations by CE-MS.

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“…For instance, tetrahydropalmatine (THP) is a crucial alkaloid isolated from YHS (Ou et al, 2006) and has been selected as a quantitative marker for quality control of both YHS and YHZT in the ChP 2020 Edition Volume I (Chinese Pharmacopoeia Commission, 2020). The asymmetric carbon of THP results in two enantiomers (Figure 1), which naturally occur in YHS and are clinically used in the form of a racemic mixture (Yan, Huang, Yahaya, & Chen, 2020;Zhai, Shi, Wu, & Luo, 2006).…”

Section: Introductionmentioning

confidence: 99%

A new strategy for quality evaluation and control of Chinese patent medicine based on chiral isomer ratio analysis: With Yuanhuzhitong tablet as an example

Gou

Geng

Liu

et al. 2021

Biomedical Chromatography

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Chiral compounds commonly exist in traditional Chinese medicine (TCM), but little research on the quality control of TCM has been conducted. In this study, a new strategy is proposed, taking Yuanhuzhitong tablet [YHZT, consisting of Radix Angelicae Dahuricae and Rhizoma Corydalis (Yan Hu Suo, YHS)] for example, which is based on chiral isomer ratio analysis to monitor the production process of Chinese patent medicine companies. In the process of content determination for tetrahydropalmatine (THP) in YHZT from different companies, noticeable differences were observed in their chromatographic behaviors. It is known that THP has two enantiomers, naturally coexisting in YHS as a racemic mixture, so we prepared THP twice and subsequently performed chiral separation analysis using supercritical fluid chromatography. As a result, the peak area ratios of two enantiomers from different companies varied remarkably, demonstrating that some companies did not probably manufacture YHZT products in accordance with the prescription proportion, used inferior or extracted YSH crude materials in the production process, and added raw chemical medicine in the production to reach the standard and lower the costs. In conclusion, the peak area ratio of chiral isomers could be taken as a key quality index.

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Enantioselective analysis in complex matrices using capillary electrophoresis-mass spectrometry: A case study of the botanical drug Corydalis Rhizoma

Cited by 12 publications

References 24 publications

Sensitivity enhancement in capillary electrophoresis and their applications for analyses of pharmaceutical and related biochemical substances

Sensitivity enhancement in capillary electrophoresis and their applications for analyses of pharmaceutical and related biochemical substances

Capillary Electrophoresis Mass Spectrometry: Developments and Applications for Enantioselective Analysis from 2011–2020

A new strategy for quality evaluation and control of Chinese patent medicine based on chiral isomer ratio analysis: With Yuanhuzhitong tablet as an example

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