Enantiomeric determination of ephedrines and norephedrines by chiral derivatization gas chromatography–mass spectrometry approaches

Wang, Sheng-Meng; Lewis, Russell J.; Canfield, Dennis V.; Li, Tien-Lai; Chen, Chang-Yu; Liu, Ray H.

doi:10.1016/j.jchromb.2005.01.016

Cited by 42 publications

(28 citation statements)

References 17 publications

(17 reference statements)

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“…In a study by S- M Wang et al, (2005) pharmaceutical drugs were analyzed using compounds that were derivatized with (-)-α-Methoxy-α-trifluoromethylphenylacetic acid (MTPA) as the derivatizing reagent. These types of derivatization reactions are represented by equation 27.…”

Section: (-)-α-Methoxy-α-trifluoromethylphenylacetic Acid (Mtpa)mentioning

confidence: 99%

Derivatization Reactions and Reagents for Gas Chromatography Analysis

Orata¹

2012

Advanced Gas Chromatography - Progress in Agricultural, Biomedical and Industrial Applications

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Section: (-)-α-Methoxy-α-trifluoromethylphenylacetic Acid (Mtpa)mentioning

confidence: 99%

Derivatization Reactions and Reagents for Gas Chromatography Analysis

Orata¹

2012

Advanced Gas Chromatography - Progress in Agricultural, Biomedical and Industrial Applications

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“…Being the sole experimented pair of primary amine synthetic cathinone-L-TPC diastereomers in the latter group's study, 4-methylcathinone-L-TPC diastereomers were greatly resolved (R s = 14.89) compared to the best resolved pair, 4-methoxymethcathinone-L-TPC diastereomers (R s = 8.92), among the thirty secondary amine synthetic cathinone-L-TPC diastereomers. Before the explosion of synthetic cathinones in drug markets, L-TPC was used successfully for chiral derivatisation of cathinone and phenalkylamines [33,34] and methcathinone [5]. In the former two studies, MTPA anhydride was also used and has been applied to analysis of real samples, i.e.…”

Section: Gas Chromatography (Gc)mentioning

confidence: 99%

“…In the former two studies, MTPA anhydride was also used and has been applied to analysis of real samples, i.e. khat plant materials [33] and over-the-counter cold remedies [34]. The anhydride form of MTPA was prepared in situ by a reaction between N,N-dicyclohexylcarbodiimide (DCC) and the original acid (Fig.…”

Section: Gas Chromatography (Gc)mentioning

confidence: 99%

Chiral and stable isotope analysis of synthetic cathinones

Tai

Morrison

2017

TrAC Trends in Analytical Chemistry

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In the past decade synthetic cathinones have appeared in drug markets worldwide. Chiral analysis can provide information on relative enantiomeric abundances of synthetic cathinones in their drug products, potentially giving a signature of these products and hence linking the products or excluding them from possible sources. Additionally, due to natural variations of relative stable isotopic abundances of elements, stable isotope analysis of synthetic cathinone drug products provides the stable isotopic signature of the products and hence also has potential to provide additional information for the purpose of drug intelligence. Therefore, both molecular (chirality) and physicochemical (relative stable isotopic abundances) properties are important for forensic chemists to investigate. Chiral and isotope ratio mass spectrometric analysis are becoming increasingly important to forensic chemists and therefore this review will focus on an overview of these techniques applied to the synthetic cathinones.

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“…The separation of ephedra alkaloids was especially difficult because of their similarity in chemical structure. Techniques that had been utilized to measure ephedra alkaloids in botanicals, pharmaceutical preparations, and dietary supplements include gas chromatography (GC) [4][5][6][7], high-performance liquid chromatography (HPLC) [8][9][10][11][12][13][14][15][16], and capillary electrophoresis (CE) [17][18][19]. In GC analysis, chemical derivatization was wildly applied to enhance volatility and detection efficiency [20].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of ephedra alkaloids in traditional chinese medicines by high-performance liquid chromatography

Chen¹,

Li²,

Chen³

et al. 2012

Acta Chromatographica

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Summary.A rapid, simple, and practical high-performance liquid chromatographic method (HPLC) was developed and validated for the simultaneous determination of norephedrine (NME), norpseudoephedrine (NMP), ephedrine (E), pseudoephedrine (PE), and methylephedrine (ME) in traditional Chinese medicines (TCM) which contained Ephedrae Herba (Ephedra). This analysis could be accomplished within 12.5 min with an Alltima Phenyl Column by isocratic elution using a mixture of KH 2 PO 4 (20 mM)-acetonitrile (96:4, v/v) as the mobile phase at a flow-rate of 0.6 mL min −1 and a wavelength of 210 nm. This method was successfully applied to quantify ephedra alkaloids in both Ma-xing-gan-shi decoction and Ephedra decoction. The concentration of total ephedra alkaloids (4.62 mg mL −1 ) in Ma-xing-gan-shi decoction was much lower than that (7.10 mg mL −1 ) in Ephedra decoction. Furthermore, the concentration of NME, NMP, E, PE, and ME was significantly lower in Ma-xing-gan-shi decoction than that in Ephedra decoction, respectively. The method was easily acceptable and would be popular with most analytical laboratories.

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Enantiomeric determination of ephedrines and norephedrines by chiral derivatization gas chromatography–mass spectrometry approaches

Cited by 42 publications

References 17 publications

Derivatization Reactions and Reagents for Gas Chromatography Analysis

Derivatization Reactions and Reagents for Gas Chromatography Analysis

Chiral and stable isotope analysis of synthetic cathinones

Simultaneous determination of ephedra alkaloids in traditional chinese medicines by high-performance liquid chromatography

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