Enamel Matrix Derivative and Guided Tissue Regeneration in the Treatment of Dehiscence‐Type Defects: A Histomorphometric Study in Dogs

Sallum, Enílson Antônio; Pimentel, Suzana Peres; Saldanha, Juliana Bezerra; Nogueira-Filho, Getulio; Casati, Márcio Zaffalon; Nociti, Francisco Humberto; Sallum, Antônio Wilson

doi:10.1902/jop.2004.75.10.1357

Cited by 39 publications

(62 citation statements)

References 35 publications

(42 reference statements)

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“…2,[11][12][13][14][15][16][17][18] To provide further information on the clinical benefits mentioned in previous studies 22 the association of collagen membranes with DFDBA was chosen in order to assess the histometrical healing response and because there is a lack of research evaluating the regenerative process by means of microscopy, evaluating factors such as epithelial proliferation, cementum and bone formation, as well as residual recessions of the gingival margin.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10] Some other studies have also assessed histological periodontal regeneration, using or not resorbable membranes as barriers. 2,[11][12][13][14][15][16][17][18] Some clinical studies evaluated the combined use of membrane and bone graft in dehiscences; [19][20][21][22][23] however, there is still a lack of histological studies that evaluate the regenerative outcomes of the GTR procedure with the use of both membrane and bone graft. 13 Rosetti et al 22 (2000) evaluated the clinical results of the association between membrane and DFDBA (demineralized freeze-dried bone allograft) in humans.…”

Section: Introductionmentioning

confidence: 99%

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Treatment of gingival recession with collagen membrane and DFDBA: a histometric study in dogs

Rosetti¹,

Marcantonio

Cirelli

et al. 2009

Braz. oral res.

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In a previous study, we evaluated the findings related to the use of resorbable collagen membranes in humans along with DFDBA (demineralized freeze-dried bone allograft). The aim of this subsequent study was to histometrically evaluate in dogs, the healing response of gingival recessions treated with collagen membrane + DFDBA (Guided Tissue Regeneration, GTR) compared to a coronally positioned flap (CPF). Two types of treatment were randomly carried out in a split-mouth study. Group 1 was considered as test (GTR: collagen membrane + DFDBA), whereas Group 2 stood for the control (only CPF). The dogs were given chemical bacterial plaque control with 0.2% chlorhexidine digluconate during a 90-day repair period. Afterwards, the animals were killed to obtain biopsies and histometric evaluation of the process of cementum and bone formation, epithelial migration and gingival level. A statistically significant difference was found between groups with a larger extension of neoformed cementum (GTR = 32.72%; CPF = 18.82%; p = 0.0004), new bone (GTR = 23.20%; CPF = 09.90%; p = 0.0401) and with a smaller area of residual gingival recession in the test group (GTR = 50.69%; CPF = 59.73%; p = 0.0055) compared to the control group. The only item assessed that showed no statistical difference was epithelial proliferation on the root surface, with means of 15.14% for the GTR group and 20.34% for the CPF group (p = 0.0890). Within the limits of this study we concluded that the treatment of gingival recession defects with GTR, associating collagen membrane with DFDBA, showed better outcomes in terms of a larger extension of neoformed cementum and bone, as well as in terms of a smaller proportion of residual recessions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Treatment of gingival recession with collagen membrane and DFDBA: a histometric study in dogs

Rosetti¹,

Marcantonio

Cirelli

et al. 2009

Braz. oral res.

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“…These approaches were used to evaluate regeneration procedures using BMP, GTR, enamel matrix proteins or grafting materials as bioactive glass [54-57]. …”

Section: The Different Animal Models In Periodontologymentioning

confidence: 99%

Experimental Animal Models in Periodontology: A Review

Struillou¹,

Boutigny²,

Soueidan³

et al. 2010

TODENTJ

192

206

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In periodontal research, animal studies are complementary to in vitro experiments prior to testing new treatments. Animal models should make possible the validation of hypotheses and prove the safety and efficacy of new regenerating approaches using biomaterials, growth factors or stem cells. A review of the literature was carried out by using electronic databases (PubMed, ISI Web of Science). Numerous animal models in different species such as rats, hamsters, rabbits, ferrets, canines and primates have been used for modeling human periodontal diseases and treatments. However, both the anatomy and physiopathology of animals are different from those of humans, making difficult the evaluation of new therapies. Experimental models have been developed in order to reproduce major periodontal diseases (gingivitis, periodontitis), their pathogenesis and to investigate new surgical techniques. The aim of this review is to define the most pertinent animal models for periodontal research depending on the hypothesis and expected results.

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“…Histological findings in animal and human studies have shown that treatment of buccal recession defects with a coronally positioned flap and EMD can result not only in a covering of the gingival recession but also in the formation of cementum, PDL and bone [56,58,62,63,67,[73][74][75] . In 2 controlled clinical studies, the treatment of buccal Miller class I and II gingival recessions with a coronally positioned flap and EMD or coronally positioned flap alone were examined using the split-mouth procedure [129,130] .…”

Section: Controlled Clinical Studies In Recession Defectsmentioning

confidence: 99%

The Application of an Enamel Matrix Protein Derivative (Emdogain®) in Regenerative Periodontal Therapy: A Review

et al. 2007

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Regenerative periodontal therapy aims at reconstitution of the lost periodontal structures such as new formation of root cementum, periodontal ligament and alveolar bone. Findings from basic research indicate that enamel matrix protein derivative (EMD) has a key role in periodontal wound healing. Histological results from animal and human studies have shown that treatment with EMD promotes periodontal regeneration. Moreover, clinical studies have indicated that treatment with EMD positively influences periodontal wound healing in humans. This review aims to present an overview of evidence-based clinical indications for regenerative therapy with EMD.

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Enamel Matrix Derivative and Guided Tissue Regeneration in the Treatment of Dehiscence‐Type Defects: A Histomorphometric Study in Dogs

Abstract: Within the limits of this study, it can be concluded that EMD alone or in combination with GTR barriers may effectively promote new cementum formation. The combination of both therapies may not provide additional benefits.

Cited by 39 publications

References 35 publications

Treatment of gingival recession with collagen membrane and DFDBA: a histometric study in dogs

Treatment of gingival recession with collagen membrane and DFDBA: a histometric study in dogs

Experimental Animal Models in Periodontology: A Review

The Application of an Enamel Matrix Protein Derivative (Emdogain®) in Regenerative Periodontal Therapy: A Review

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