Enabling spectral barcoding of SERS nanotags using gold nanostars

Abstract

Surface-enhanced Raman scattering (SERS) is a non-invasive analytical technique that has ultra-sensitivity and high multiplex capability. Gold nanostars (AuNSs) with the unique near-infrared localised surface plasmon resonance has shown great...

Nanosupernova: a new anisotropic nanostructure for SERS

“…This change could be attributed to the effect of silver and possible charge transfer between DTNB molecule and silver, which makes the SERS spectrum of DTNB different from when DTNB is adsorbed on gold. 41,42 The as-synthesized SERS nanotags appear as quasi-circular particles under the TEM (Fig. 3C) and were 108.7 ± 0.8 nm in hydrodynamic size with a good polydispersity index (PDI) of 0.202 (Table S3†).…”

Emerging integrated SERS-microfluidic devices for analysis of cancer-derived small extracellular vesicles

“…The selection of Raman molecules is dependent on the stability under laser irradiation, the ability to attach on the plasmonic surface via physisorption or chemisorption, it should have large Raman scattering cross-section to provide strong signal intensity and create unique SERS peaks to avoid the overlap from the other molecules. 119,120 Typically, aromatic compounds such as 5,5′dithiobis (2-nitrobenzoic acid) (DTNB), 4-mercaptobenzoic acid (4-MBA), 4-mercaptopyridine (4-MPY) are used as Raman reporters because of their ability to form covalent bonds with the metallic core via -SH and -NH 2 groups and distinct Raman spectra. 121,122 To prevent unspecific binding to the surface of nanotag the protective layer around it is necessary to minimise interference during the detection process.…”

Role of Surface Curvature in Gold Nanostar Properties and Applications

“…SERS nanotags are Raman reporter molecules that are covalently bound to plasmonic nanoparticles (e.g., AuNSs), which enhance their spectroscopic signals . SERS nanotags do not photobleach, and the number of dyes (and dye combinations) with different SERS peaks is almost unlimited, due to the large number of molecules that are SERS active. , …”

“…83 SERS nanotags do not photobleach, and the number of dyes (and dye combinations) with different SERS peaks is almost unlimited, due to the large number of molecules that are SERS active. 84,85 Exploiting AuNS-based SERS imaging, the 3D structure of complex cell models mimicking biological tissue was imaged by embedding SERS nanotags in fibroblasts. 86 The dense sandwich-like multilayer cell models were composed of alternating dermal fibroblast layers with or without SERS nanotag labeling, to simulate complex tissue with different cell populations.…”