Emerging integrated SERS-microfluidic devices for analysis of cancer-derived small extracellular vesicles

Abstract

Cancer-derived small extracellular vesicles (sEVs) are specific subgroups of lipid bilayer vesicles secreted from cancer cells to the extracellular environment. They carry distinct biomolecules (e.g., proteins, lipids and nucleic acids)...

Microfluidic-SERS Technologies for CTC: A Perspective on Clinical Translation

“…SERS is a phenomenon that occurs when the Raman signal from molecules is dramatically enhanced near the plasmonic nanoparticle surface. SERS has proven invaluable in biomedical applications, offering the ability to detect low analyte concentrations in complex media, which is especially favorable for CTC detection. , They can be categorized into two primary detection approaches (Figure ):…”

“…SERS has proven invaluable in biomedical applications, offering the ability to detect low analyte concentrations in complex media, which is especially favorable for CTC detection. 67,68 They can be categorized into two primary detection approaches (Figure 3): SERS label: this method detects analytes using SERS nanotags, which are SERS-active nanoparticles with Ramanactive molecules or chromophore-based dyes. These nanotags generate distinctive and intense spectral bands.…”

Dual-Mode Separation and SERS Detection of Carbaryl with PA-6/AuNRs@ZIF-8 Films

“…As a result, a large number of relevant methods have been developed in recent years. 14,15 However, a large number of them still suffer from shortcomings, such as lack of simplicity and long processing time. Metal−organic frameworks (MOFs) consist of metal ions and organic ligands bonded by coordination and have a large internal specific surface area and the ability of molecule separation.…”

“…Surface-enhanced Raman spectroscopy (SERS) gained a large amount of popularity in recent years as an analytical method capable of analyzing molecular fingerprints, which allows rapid and highly sensitive capture of information about molecules. − Due to the remarkable enhancement effect, its responses to impurities are also extremely good. , Therefore, the development of preseparation and enrichment methods for analytes is crucial in SERS methods. As a result, a large number of relevant methods have been developed in recent years. , However, a large number of them still suffer from shortcomings, such as lack of simplicity and long processing time. Metal–organic frameworks (MOFs) consist of metal ions and organic ligands bonded by coordination and have a large internal specific surface area and the ability of molecule separation. − Encapsulating metal nanoparticles into MOFs as a core–shell structure can be conducive to enhanced selectivity and stability in applications such as SERS sensing.…”

Ag-coated tetrapod gold nanostars (Au@AgNSs) for acetamiprid determination in tea using SERS combined with microfluidics

“…17,37,38 The basic distinction between the two primary varieties of SERS-microuidic systems is whether the SERS enhancement base is xed to the microchannel. [39][40][41] When the substrate is xed on the surface of the microchannel, the system tends to be stable, although with higher operational costs and lower chip repeatability. However, when the substrate is in liquid form, the substrate and the detection object are mixed within the channel, the operation is simple and the chip exhibits stronger repeatability.…”