Emulsion-Based Delivery Systems for Tributyrin, a Potential Colon Cancer Preventative Agent

Li, Yan; Maux, Solène Le; Xiao, Hang; McClements, David Julian

doi:10.1021/jf901836f

Cited by 111 publications

(61 citation statements)

References 23 publications

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“…In comparison to nanoemulsion control, it was much less cytotoxic on cancer cells. There was a report that showed that the surfactants themselves can influence MTT assay [40]. However, concentration of Tween 80 in nanoemulsion of this experiment did not affect cell cytotoxicity as shown in Figure 8.…”

Section: Discussionmentioning

confidence: 57%

Preparation of Lipid Nanoemulsions Incorporating Curcumin for Cancer Therapy

Anuchapreeda

Fukumori

Okonogi

et al. 2012

Journal of Nanotechnology

101

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The aim of this study was to develop a new formulation of a curcumin lipid nanoemulsion having the smallest particle size, the highest loading, and a good physical stability for cancer chemotherapy. Curcumin lipid nanoemulsions were prepared by a modified thin-film hydration method followed by sonication. Soybean oil, hydrogenated l-α-phosphatidylcholine from egg yolk, and cosurfactants were used to formulate the emulsions. The resultant nanoemulsions showed mean particle diameter of 47-55 nm, could incorporate 23-28 mg curcumin per 30 mL, and were stable in particle size for 60 days at 4• C. The cytotoxicity studies of curucumin solution and curcumin-loaded nanoemulsion using B16F10 and leukemic cell lines showed IC 50 values ranging from 3.5 to 30.1 and 22.2 to 53.7 μM, respectively. These results demonstrated the successful incorporation of curcumin into lipid nanoemulsion particles with small particle size, high loading capacity, good physical stability, and preserved cytotoxicity.

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Section: Discussionmentioning

confidence: 57%

Preparation of Lipid Nanoemulsions Incorporating Curcumin for Cancer Therapy

Anuchapreeda

Fukumori

Okonogi

et al. 2012

Journal of Nanotechnology

101

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“…Tributyrin is a small non-polar molecule that has a relatively high water-solubility, and is therefore highly prone to Ostwald ripening. 3,118 On the other hand, corn oil contains large non-polar triacylglycerol molecules with a very low water-solubility, and therefore emulsions prepared from it are highly stable to OR.…”

Section: 118mentioning

confidence: 99%

“…17 Droplet growth in oil-in-water nanoemulsions containing different amounts of corn oil and tributyrin in the oil phase. 118 The inset shows the mean particle size after 24 hours for different initial corn oil concentrations in the oil phase.…”

Section: 123mentioning

confidence: 99%

Edible nanoemulsions: fabrication, properties, and functional performance

2011

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There is increasing interest within the food, beverage and pharmaceutical industries in utilizing edible nanoemulsions to encapsulate, protect and deliver lipophilic functional components, such as oil-soluble flavors, vitamins, preservatives, nutraceuticals, and drugs. There are a number of potential advantages of using nanoemulsions rather than conventional emulsions for this purpose: they can greatly increase the bioavailability of lipophilic substances; they scatter light weakly and so can be incorporated into optically transparent products; they can be used to modulate the product texture; and they have a high stability to particle aggregation and gravitational separation. On the other hand, there may also be some risks associated with the oral ingestion of nanoemulsions, such as their ability to change the biological fate of bioactive components within the gastrointestinal tract and the potential toxicity of some of the components used in their fabrication. This tutorial review provides an overview of the current status of nanoemulsion fabrication, properties, and applications with special emphasis on systems suitable for utilization within the food industry.

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“…Li et al [19] have demonstrated that Tween 80 affected the results of MTT assay, which is similar to SRB assay, when screening for the cytotoxicity of drugs by detecting biochemical changes on the cell membrane. When Tsai et al [11] administered the drug-free microemulsions into the rats, they found out that the microemulsions caused inflammation according to their histological evaluation of rat bladder tissues.…”

Section: Discussionmentioning

confidence: 99%