Emulsifier‐Free Emulsion Copolymerization of Vinyl Acetate and 3‐Dimethyl(methacryloyloxyethyl)ammonium Propanesulfonate and Swelling Behavior of their Copolymer Matrices

Kamenska, Elena; Kostova, Bistra; Ivanov, Ivo; Rachev, Dimitar; Georgiev, Georgi V.

doi:10.1002/mren.200700013

Cited by 11 publications

(3 citation statements)

References 33 publications

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“…In the presence of salt, the site binding ability of cation and anion allows reduction of interchain interaction between the polymer chains, showing characteristic antipolyelectrolyte behavior. In the absence of salt or low salt, the latex tends to aggregate due to strong particle–particle interactions that lead to an increase in the average particle size with a broader particle size distribution . The average diameter of PS/PSB initially increases and then decreases monotonically with the addition of salt as typically observed in polysulfobetaine solutions. , The initial increase in size and PDI is due to significant particle cluster interaction and formation of larger aggregates, which can be attributed to the initial salt screening.…”

Section: Resultsmentioning

confidence: 90%

Unique Oil-in-Brine Pickering Emulsion Using Responsive Antipolyelectrolyte Functionalized Latex: A Versatile Emulsion Stabilizer

Vasantha

Hua

Rusli

et al. 2020

ACS Appl. Mater. Interfaces

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A simple and straightforward approach to synthesize oil-in-water (O/W) emulsions under high salinity and temperature using zwitterion-functionalized latexes are presented in this work. First, well-defined functionalized latexes were synthesized by emulsifier-free emulsion copolymerization in the presence of precursor sulfobetaine comonomer using brine as a continuous phase. The surface-functionalized latex particles were then characterized by DLS, SEM, TEM, XPS, and TGA. The functionalized latex exhibited antipolyelectrolyte behavior in high salinity brine and at high temperatures. The effects of salinity, temperature, and pH on the long-term stability of the particles were investigated. Further, to evaluate the potential in high salinity brine and high temperature, the saltphilic functionalized latexes were utilized to stabilize the oil/brine (O/W) interface without any other additives. The latex enabled the formation of a stable Pickering emulsion system with low solid content (<0.02% w/w) in the presence of 50% v/v n-decane. The functionalized latexes were self-assembled at the O/W interface as a spherical colloidosome in high salinity brine through hydrophobic interactions and irreversible adsorption. The supraparticles were imaged with SEM, providing an insight that the exterior of the emulsion droplets is stabilized by the saltphilic latex particles, forming a protective layer at the oil−water interface through electrostatic repulsion. The antipolyelectrolyte latex can be utilized as a novel emulsion stabilizer, which can provide a versatile alternative for applications in a complex environment such as high salinity, temperature, and low or high pH.

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Section: Resultsmentioning

confidence: 90%

Unique Oil-in-Brine Pickering Emulsion Using Responsive Antipolyelectrolyte Functionalized Latex: A Versatile Emulsion Stabilizer

Vasantha

Hua

Rusli

et al. 2020

ACS Appl. Mater. Interfaces

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“…Emulsifier-free emulsion co-polymerization of VA and DMAPS. -Emulsifier-free emulsion copolymerization (EFC) of VA and DMAPS was performed in water using the method described in our previous paper (22). The VA/DMAPS mole ratios in the monomer feed were 90/10 (co-polymer 1), 85/15 (co-polymer 2), 80/20 (co-polymer 3) and 70/30 (co-polymer 4).…”

Section: Methodsmentioning

confidence: 99%

New co-polymer zwitterionic matrices for sustained release of verapamil hydrochloride

Kostova¹,

Rachev²

2007

Acta Pharmaceutica

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Stable co-polymer [vinyl acetate-co-3-dimethyl(methacryloyloxyethyl) ammonium propane sulfonate, p(VA-co-DMAPS)] latex of different compositions has been synthesized for the first time by emulsifier-free emulsion copolymerization. The unusual >>overshooting<< behavior of the co-polymer tablets has been explained by the formation of specific clusters from the opposite oriented dipoles-zwitterionic species. The change of their concentration with the DMAPS unit fraction (mDMAPS), pH and ionic strength has been considered responsible for the differences observed in the swelling kinetics. The results obtained prove that mDMAPS and ionic strength could be used to control the swelling degree of the p(VA-co-DMAPS) matrices and their sustained drug delivery. In this way, p(VA-co-DMAPS) matrices could be effectively used to control the sustained release of drugs with basic properties like verapamil hydrochloride from model tablets.

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“…In our previous paper (9,10), were presented the synthesis and characterization of copolymer nano-sized latex particles based on vinyl acetate (VA) and 3-dimethyl (methacryloyloxyethyl) ammonium propane sulfonate (DMAPS) (p(VA-co-DMAPS)) prepared by emulsifier-free emulsion copolymerization (EEC) in water. It was established that the change of the initial monomer feed led to changes in the type and mechanism of EEC, as well as the shape, the average diameter and the morphology of the copolymer nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Design and Concept of Polyzwitterionic Copolymer Microgel Drug Delivery Systems In Situ Loaded with Non-steroidal Anti-inflammatory Ibuprofen

Kostova

Kamenska²,

Georgieva

et al. 2016

AAPS PharmSciTech

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Nowadays, the modern pharmaceutical investigations are directed toward obtaining of new polymer micro-and nano-sized drug delivery carriers. In this respect, the use of hydrogel carriers based on polyzwitterions (PZIs) is an opportunity in the preparation of polymer drug delivery systems with desired characteristics. This paper describes the synthesis and characterization of micro-structured p(VA-coDMAPS) systems with different compositions in situ loaded with Ibuprofen by emulsifier-free emulsion copolymerization (EEC) in water. The mean size of the prepared microparticles was measured by SEM and particles have been visualized by AFM. The inclusion of Ibuprofen in the polyzwitterionic copolymer microgel systems was established by using DSC. In vitro drug release experiments were carried out in order to estimate the ability of the obtained microgels to modify the release of water-insoluble Ibuprofen.

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Emulsifier‐Free Emulsion Copolymerization of Vinyl Acetate and 3‐Dimethyl(methacryloyloxyethyl)ammonium Propanesulfonate and Swelling Behavior of their Copolymer Matrices

Cited by 11 publications

References 33 publications

Unique Oil-in-Brine Pickering Emulsion Using Responsive Antipolyelectrolyte Functionalized Latex: A Versatile Emulsion Stabilizer

Unique Oil-in-Brine Pickering Emulsion Using Responsive Antipolyelectrolyte Functionalized Latex: A Versatile Emulsion Stabilizer

New co-polymer zwitterionic matrices for sustained release of verapamil hydrochloride

Design and Concept of Polyzwitterionic Copolymer Microgel Drug Delivery Systems In Situ Loaded with Non-steroidal Anti-inflammatory Ibuprofen

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