Emulsified silicone oil is taken up by and induces pro-inflammatory response in primary retinal microglia

Klettner, Alexa; Harms, Antonia; Waetzig, Vicki; Tode, Jan; Purtskhvanidze, Konstantine; Roider, Johann

doi:10.1007/s00417-020-04763-z

Cited by 11 publications

(14 citation statements)

References 31 publications

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“…The toxicity of SO to the retinal neurons might be an explanation and had been widely discussed [ 11 , 36 , 37 ]. The inner retina is in direct contact with SO, and experimental evidence in vitro has shown that emulsified SO can be taken up by primary retinal microglia, where it induces a pro-inflammatory response [ 38 ]. Studies with enucleated eyes applied with SO tamponade confirmed that intraretinal macrophages contained phagocytosed SO, and the eccentric pigment granules were present in the superficial retina [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Changes of macular vessel density and thickness in gas and silicone oil tamponades after vitrectomy for macula-on rhegmatogenous retinal detachment

et al. 2021

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Purpose To investigate the macular vessel density and thickness in macular-on rhegmatogenous retinal detachment (RRD) after vitrectomy with gas and silicone oil (SO) tamponade. Methods Patients with macular-on RRD eyes, treated with a single successful vitrectomy with gas or SO tamponade and a minimum 30 months follow-up, were reviewed. Best-corrected visual acuity (BCVA), macular vessel density and retinal thickness by using optical coherence tomography angiography, were compared to the contralateral eyes. Results Sixteen eyes with gas tamponade and 17 eyes with SO tamponade were included in the study. LogMAR best-corrected visual acuity (BCVA) slightly improved from 0.25 ± 0.18 (Snellen 20/36) to 0.17 ± 0.23 (Snellen 20/30) in eyes with gas tamponade, and decreased from 0.30 ± 0.22 (Snellen 20/40) to 0.49 ± 0.28 (Snellen 20/62) in eyes with SO tamponade. The parafoveal vessel densities in superficial vascular complex (SVC) and the corresponding inner retinal thickness (IRT) were similar between the affected eyes and the contralateral eyes in gas tamponade group (P = 0.578, P = 0.943), while significantly reduced in the affected eyes, compared to the contralateral eyes in SO tamponade group (P < 0.001, P < 0.001). Conclusion Eyes in SO tamponade group had worse BCVA, lower SVC vessel densities and thinner corresponding IRT after vitrectomy for macular-on RRD, than those in gas tamponade group.

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Section: Discussionmentioning

confidence: 99%

Changes of macular vessel density and thickness in gas and silicone oil tamponades after vitrectomy for macula-on rhegmatogenous retinal detachment

et al. 2021

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“…Some studies have suggested that SO can induce intraocular inflammation and retinal toxicity, which may also contribute to poor visual recovery in eyes with an extended course of SO in situ. 21–23 Because almost 95% of the cohort was pseudophakic at the final follow-up visit, cataract progression had minimal impact on visual acuity outcomes in this study. Ultimately, the removal of SO is a clinical decision tailored to each patient's clinical scenario and the presence of any complications.…”

Section: Discussionmentioning

confidence: 96%

Factors Affecting Retinal Redetachment After Silicone Oil Removal for Rhegmatogenous Retinal Detachments

Huang¹,

Starr²,

Patel³

et al. 2022

Retina

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Purpose: To report factors affecting the retinal redetachment rate after silicone oil removal (SOR) following rhegmatogenous retinal detachment (RRD) repair.Methods: Retrospective cohort study from December 1, 2014, to March 1, 2020, of 205 consecutive patients treated for RRD with silicone oil (SO) tamponade and subsequent SOR with at least 6-month follow-up. Primary outcome measure was the rate of retinal redetachment after SOR.Results: The retinal redetachment rate after SOR was 18.5%. Preoperative macula and lens status, proliferative vitreoretinopathy, previous retinectomy, retinal detachment size, concomitant phacoemulsification, previous scleral buckling, and endolaser during SOR did not affect the redetachment rate after SOR. Previous SO exchange was associated with increased redetachment (OR 2.53,], P = 0.0278). Twelve months of SO tamponade had lower redetachment rates compared with 3 months (OR 0.25, 95% CI [0.04-0.09], P = 0.048). Shorter SO tamponade (3 vs. 12 months) had better final visual outcomes after SOR (0.80 ± 0.61 vs. 1.41 ± 0.66, P , 0.0001). Conclusion:No preoperative or intraoperative factors in this analysis influenced the risk of redetachment after SOR except duration of SO tamponade and previous SO exchange. Although longer SO tamponade duration may be associated with lower rates of redetachment, visual outcomes may be worse.

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“…Nevertheless, these changes did not reach the level of statistical significance ( p = 0.44) [ 42 ]. In addition, the inner retinal layers were shown to be much thinner in the presence of SO tamponade in comparison to healthy eyes in two separate tests that were carried out by Purtskhvanidze et al and Caramoy et al [ 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Retinal Nerve Fiber Layer Changes after Intraocular Silicone Oil Tamponade in Rhegmatogenous Retinal Detachment

Chikmah

Ichsan

Islam

et al. 2023

Vision

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Rhegmatogenous retinal detachment (RRD) is a serious and emergency condition that may cause visual disturbance. Treatment includes pars plana vitrectomy with a tamponade such as intraocular gas or silicone oil (SO). In many countries, silicone oil is still favorable compared to intraocular gases as tamponade for reattachment of retinal detachment surgery. The application provides a higher anatomical success rate, especially in cases of proliferative vitreoretinopathy (PVR) that were previously considered untreatable. Objective assessment of the retinal nerve fiber layer (RNFL) using optical coherence tomography (OCT) in the eye with silicone oil tamponade is a challenge because of the limitations and difficulties in taking images. This study aims to assess the RNFL thickness changes in rhegmatogenous retinal detachment patients using SO tamponade and its subsequent removal conducted on a total of 35 post-operative RRD patients. Central macular and RNFL thickness, as well as best-corrected visual acuity (BCVA), were recorded at the time of tamponade and after the removal of the SO at 1, 4, and 8 weeks, respectively. The results showed that the changes in RNFL thickness significantly decreased in the group of ≤6 months, especially in the superior and temporal quadrants, and BCVA increased after SO removal (p < 0.05). Central macular thickness was significant (p < 0.001) at the end of the visit. Improved visual acuity is associated with decreased RNFL and central macular thickness after SO removal.

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Emulsified silicone oil is taken up by and induces pro-inflammatory response in primary retinal microglia

Cited by 11 publications

References 31 publications

Changes of macular vessel density and thickness in gas and silicone oil tamponades after vitrectomy for macula-on rhegmatogenous retinal detachment

Changes of macular vessel density and thickness in gas and silicone oil tamponades after vitrectomy for macula-on rhegmatogenous retinal detachment

Factors Affecting Retinal Redetachment After Silicone Oil Removal for Rhegmatogenous Retinal Detachments

Retinal Nerve Fiber Layer Changes after Intraocular Silicone Oil Tamponade in Rhegmatogenous Retinal Detachment

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