Changes of macular vessel density and thickness in gas and silicone oil tamponades after vitrectomy for macula-on rhegmatogenous retinal detachment

Liu, Yang; Lei, Boya; Jiang, Rui; Huang, Xin; Zhou, Min; Xu, Gezhi

doi:10.1186/s12886-021-02160-6

Cited by 8 publications

(13 citation statements)

References 41 publications

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“…Regarding the effects on full retinal thickness and thickness between the inner limiting membrane and inner plexiform layer, SO had more negative tamponade effects than Gas, with no statistically significant intergroup differences. These trends were almost consistent with previous studies in RRD eyes (Inan et al, 2020;Zhou et al, 2020;Liu et al, 2021), although the etiology and mechanisms of RRD and PDR were quite different.…”

Section: Discussionsupporting

confidence: 92%

“…A retrospective study completed by Inan et al (2020) found thinning in the layers of the ganglion cell layer, outer plexiform layer, and outer nuclear layer in the SO group. Moreover, Liu et al (2021) reported that the parafoveal vessel densities in the SVC and the corresponding inner retinal thickness were significantly reduced in the affected eyes compared to the contralateral eyes in the SO group but similar between the affected eyes and the contralateral eyes in the Gas group. These studies suggest that the use of SO tamponade affects retinal layer thickness more significantly than perfluoropropane gas tamponade in eyes with RRD.…”

Section: Discussionmentioning

confidence: 91%

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Comparison of Retinal Changes Following Silicone Oil and Perfluoropropane Gas Tamponade for Proliferative Diabetic Retinopathy Patients

Wang

Chen

et al. 2022

Front. Physiol.

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Purpose: To investigate the different tamponade effects of intravitreal silicone oil (SO) and perfluoropropane gas on the retinal structure and vasculature in proliferative diabetic retinopathy (PDR) patients.Methods: Thirty-eight eligible patients (47 eyes) with PDR requiring pars plana vitrectomy (PPV) were enrolled in the prospective observational study. Subjects were divided into two groups after PPV: SO group subjects underwent SO tamponade, whereas Gas group subjects underwent perfluoropropane gas tamponade. The primary outcomes of this study were longitudinal changes in retinal structure and vasculature between 10 and 90 days after the operation. Secondary outcomes were longitudinal changes in peripapillary retinal nerve fiber layer (pRNFL) thickness between 10 and 90 days after the operation in each sector.Results: Thirty-six eyes of 27 patients with a median age of 56.6 ± 9.8 years completed follow-up and were statistically analyzed. No significant difference in demographics or clinical characteristics was found between the two groups. Eyes in the SO group had a statistically significant decrease in pRNFL thickness at 90 days after PPV (p < 0.001), and there was a significant intergroup difference compared with the Gas group (p = 0.001), except for the temporal sector. Eyes in the Gas group had a statistically significant increase in parafoveal vessel density (VD) of the superficial vascular complex (SVC) at 90 days after PPV (p = 0.023), although there was no significant intergroup difference. The type of tamponade, changes in full retina thickness, and parafoveal SVC VD showed a significant correlation with changes in pRNFL thickness (all p < 0.05).Conclusion: SO tamponade resulted in a significantly greater decrease in pRNFL over 90 days than gas tamponade in patients with PDR. In addition, the change in the pRNFL was significantly correlated with changes in full retina thickness and SVC VD after the operation.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 91%

Comparison of Retinal Changes Following Silicone Oil and Perfluoropropane Gas Tamponade for Proliferative Diabetic Retinopathy Patients

Wang

Chen

et al. 2022

Front. Physiol.

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“…In detail, the multivariate regression analyses showed that only the type of tamponade was significantly correlated with the final BCVA in the Macula-ON group, as eyes filled with gas had a better final BCVA then those filled with SO and this is in line with some previous studies [ 13 , 14 ].…”

Section: Discussionsupporting

confidence: 89%

Long-Term Macular Vascular Changes after Primary Rhegmatogenous Retinal Detachment Surgery Resolved with Different Tamponade or Different Surgical Techniques

Gironi

D’Aloisio

Verdina

et al. 2022

Life

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Background: The aim of this study was to assess long-term macular vascular changes and their correlation with functional recovery in patients successfully treated for Macula-ON and Macula-OFF rhegmatogenous retinal detachment (RRD). Methods: This retrospective observational study included 82 eyes of 82 patients who received primary successful retinal detachment surgery, 33 Macula-ON and 49 Macula-OFF. Superficial and deep capillary plexuses (SCP and DCP) were evaluated by optical coherence tomography angiography (OCTA), and were correlated with visual acuity (VA), surgical technique and tamponade at 12 months after surgery. The fellow eyes were used as controls. Results: At 12-month follow-up, there was a significant decrease in the vessel density (VD) in the SCP in the operated eyes compared to control eyes (p < 0.05) in both the Macula-ON and Macula-OFF groups. Vessel length density (VLD) decrease in SCP was more extended in the Macula-OFF group. No difference in the DCP perfusion parameters was found, compared to controls. Subgroup analysis dependent on the type of surgery or tamponade showed no significant differences of VD and VLD. An inverse correlation was found between the SCP VD and the duration of silicone oil (SO) tamponade (p = 0.039). A significant correlation was observed between parafoveal SCP VD and final best corrected visual acuity (BCVA) (p = 0.028). The multivariate linear regression analysis showed that only the type of tamponade was significantly correlated with the final BCVA in the Macula-ON group (p = 0.004). Conclusions: Our study described long-term perfusion changes in RRD after surgery, with lower SCP VD and VLD in the operated eyes compared to the fellow ones, not influenced by type of surgery or tamponade. The choice of tamponade and SO removal timing may affect functional outcomes, especially in Macula-ON RRD. In conclusion, such functional and perfusion changes can be considered biomarkers that highlight the relevance of careful management of this sight-threatening disease.

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“…On the one hand, it has been hypothesized that the SCP and the superficial retinal layers, being in contact with SO, could be more susceptible to potential SO-related mechanical/cytotoxic damage [ 159 ]; on the other hand, the DCP is considered more susceptible to ischemic damage due to its intraretinal location [ 162 ]. In addition, Liu et al [ 163 ] speculated that the superficial vascular changes might also be related to the elevation of IOP as they found a decreased parafoveal SCP VD only in eyes that had experienced raised IOP during the follow-up. It has to be highlighted that most of the studies evaluating SO-related changes on OCTA have been performed in eyes treated for macula-off RD and, thus the results have to be interpreted with caution.…”

Section: Retinal Changes Associated With Silicone Oilmentioning

confidence: 99%

“…Indeed, the macular detachment itself may induce macular vascular changes in up to 71.1% of cases in the absence of SO endotamponade [ 164 ]. However, a lower parafoveal VD in the superficial capillary plexus (SCP) has been reported when comparing SO-filled eyes with air-filled after macula-off RD repair [ 159 ] and gas-filled eyes after macula-on RD repair [ 163 ]; this may support a specific role of SO in macular microvasculature effects. Moreover, the nasal sector and the FAZ of DCP may be more impaired in case of macular detachment [ 161 ].…”

Section: Retinal Changes Associated With Silicone Oilmentioning

confidence: 99%

Retinal and Corneal Changes Associated with Intraocular Silicone Oil Tamponade

Ferrara

Coco

Sorrentino

et al. 2022

JCM

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Silicone oils (SO) are used as long-term intraocular tamponades and have an irreplaceable role in vitreoretinal surgery. They can, however, be associated with multiple and potentially severe complications, involving different ocular tissues, in particular retina and cornea. Recent advances in ophthalmic imaging have allowed the precise characterization of retinal and corneal microstructural changes, at a subclinical level. This detailed analysis of SO-related retinal and corneal changes has improved our understanding of their pathogenesis and offer the potential for optimized monitoring and management of patients with SO-filled eyes. This review aims to provide clinicians and ophthalmic scientists with an updated and comprehensive overview of the corneal and retinal changes associated with SO tamponade.

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Changes of macular vessel density and thickness in gas and silicone oil tamponades after vitrectomy for macula-on rhegmatogenous retinal detachment

Cited by 8 publications

References 41 publications

Comparison of Retinal Changes Following Silicone Oil and Perfluoropropane Gas Tamponade for Proliferative Diabetic Retinopathy Patients

Comparison of Retinal Changes Following Silicone Oil and Perfluoropropane Gas Tamponade for Proliferative Diabetic Retinopathy Patients

Long-Term Macular Vascular Changes after Primary Rhegmatogenous Retinal Detachment Surgery Resolved with Different Tamponade or Different Surgical Techniques

Retinal and Corneal Changes Associated with Intraocular Silicone Oil Tamponade

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