EMSCs‐Seeded Micro‐Stripe Patterned Polycaprolactone Promoting Sciatic Nerve Regeneration

Abstract

after PNI, such as degeneration of nerve cells and disintegration of the axon, which result in neuropathic pain, permanent loss of sensation, and motor control. [2] Although peripheral nerves have the potential for axonal regeneration upon injury, clinical outcomes of long-distance PNI are not always satisfactory. [3] Nerve grafting remains the clinical gold standard for repairing large nerve gaps. [4] The technical support is very limited, because the autologous nerve graft is not readily available, and secondary surgery significantly increases surgical site morbidity of dysfunction. [5] Thus, it is necessary to take an alternative approach to recombine longdistance nerve gaps and guide nerve fibers orderly. An effective nerve grafting would achieve satisfactory functional recovery with few complications.Many studies have shown that synthetic or natural polymers nerve guidance conduits (NGC) were considered one of the most promising strategies for treating PNI. [6] So far biomimetic architecture, flexibility, and biodegradability are fundamental requirements for an ideal NGC. [7] Plenty of materials, such as synthetic poly-l-lactide acid (PLLA), [8] polycaprolactone (PCL), [9] and some natural biomaterials [10] including chitosan and fibrin, had been used for the fabrication of NGC. Among them, PCL is one of the most

Ultraviolet-curable Material with High Fluorine Content for Biomimetic Functional Structures Achieved by Nanoimprint Lithography with Gas-permeable Template for Life Science and Electronic Applications

“…We employed pattern fabrication and created surface functions on high-fluorine materials by UV nanoimprint lithography, a type of pattern fabrication process. Nanoimprint lithography is a simple, high-precision, high-resolution, and largearea pattern fabrication technique [34] [35] with a wide range of applications in the field of electronics [36], such as semiconductors [37][38] and solar cells [39] [40], and the field of life science [41], such as microneedles [42][43] and cell culture scaffolds [44] [45].…”