Empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly

Duan, Dandan; Dong, Yuanli; Zhang, Hua; Zhao, Yong; Diao, Yun-Peng; Chen, Yi; Wang, Juan; Chai, Qiang; Liu, Zhendong

doi:10.1038/srep43816

Cited by 26 publications

(38 citation statements)

References 47 publications

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“…Third, we did not consider the influence of genetic factors and sex differences. It has been demonstrated that genetic influences are not uniform throughout the brain [ 29 , 30 ]. Sex hormones play an important role in the sexual differentiation of white matter microstructure [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Low carotid wall shear stress independently accelerates the progression of cognitive impairment and white matter lesions in the elderly

et al. 2017

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The association of hemodynamics with cognitive impairment and white matter lesions (WMLs) has come to the foreground in recent years. Six hundred eighty-nine elderly participants aged ≥60 years were eligible enrolled. After an average of 5.4 years follow-up, there was a significant decline in Mini-Mental State Examination (MMSE) scores and increases in total white matter hyperintensities (WMH), periventricular (P)WMH, and deep (D)WMH (P < 0.001). The participants were grouped by the tertiles of carotid mean wall shear stress (WSS). The decline in MMSE scores and the increases in total WMH, PWMH, and DWMH decreased from the lowest group to the highest group. There were significant differences between each group comparison (all P <0.05). Mean WSS was an independent and significant factor for the changes in MMSE scores, total WMH, PWMH, and DWMH after adjustment for confounders (P <0.001). The risk of developing cognitive impairment was higher in the lowest (hazard ratio: 2.753; 95% CI: 1.945 to 3.895; P < 0.001) and intermediate (hazard ratio: 1.531; 95% CI: 1.084 to 2.162; P = 0.015) groups than in the highest group after adjustment for confounders. Similar associations were yielded between peak WSS and the changes in MMSE scores, total WMH, PWMH, and DWMH. Our results indicated that carotid WSS is an independent factor for the progression of cognitive impairment and WMLs in the elderly. Low WSS significantly deteriorates the progression of cognitive impairment and WMLs.

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Section: Discussionmentioning

confidence: 99%

Low carotid wall shear stress independently accelerates the progression of cognitive impairment and white matter lesions in the elderly

et al. 2017

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“…Following Duan et al (2017) , we defined empty-nester older adults as those who lived alone or with spouses/partners, but with no child (code = 1), and non–empty-nester older adults as those who lived with (a) child (ren) (code = 0).…”

Section: Methodsmentioning

confidence: 99%

The longitudinal relationship between income and social participation among Chinese older people

Feng

Cramm

Jin

et al. 2020

SSM - Population Health

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The vital role of active social participation in older people’s lives is widely acknowledged. The maintenance of adequate levels of social participation is an essential element of successful aging. Low income may inhibit older people from engaging in social activities. Given its recent rapid economic growth, China provides a unique setting for the study of changes in income and social participation among older people over time. In this study, the longitudinal relationship between income and social participation among Chinese older people was investigated using a nationally representative dataset from three waves of the China Health and Retirement Longitudinal Study (CHARLS). At baseline, a total of 3863 participants with a mean age of 60.4 years (range: 50-89) were included in our study; 49.9% of the participants were female, and 64.4% lived in rural areas. Generalized estimating equations were used to analyze the longitudinal relationship between income and social participation, with and without adjustment for background variables (age, gender, marital status, educational level, empty-nest status, area of residence, and multimorbidity). The results of unadjusted and adjusted analyses clearly showed a longitudinal association between income and social participation. People from the highest income group were almost two times more likely to participate in social activities than were those from the lowest income group. People with a higher educational level are also more likely to participate in social activities compared to people with a lower educational level. Being married and living with children decreased the odds of social participation. Social participation is also less likely among older aged and those living in rural areas. Our findings indicate that higher income levels are associated positively with social participation over time among older people in China.

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“…Furthermore, the left-behind elderly parents experience higher degrees of loneliness, depressive symptoms, and cognitive impairment. Magnetic resonance imaging showed that the left-behind elderly parents have a higher progression of structural brain changes (white matter lesions) than the not-left-behind elderly parents [ 15 ]. Approximately 10.9% to 43.6% of the left-behind elderly parents in the rural areas of China suffer from moderate to serious loneliness [ 16 ], while in Europe, the prevalence of depression in community-dwelling populations above 65 years of age is approximately 12.3% [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Left-Behind Status Worsens Prognosis of ST-Elevation Myocardial Infarction in Elderly Patients from Southwest China

Cao

Zhang

et al. 2020

Med Sci Monit

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Empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly

Cited by 26 publications

References 47 publications

Low carotid wall shear stress independently accelerates the progression of cognitive impairment and white matter lesions in the elderly

Low carotid wall shear stress independently accelerates the progression of cognitive impairment and white matter lesions in the elderly

The longitudinal relationship between income and social participation among Chinese older people

Left-Behind Status Worsens Prognosis of ST-Elevation Myocardial Infarction in Elderly Patients from Southwest China

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