Employing of Fe3O4/CuO/ZnO@MWCNT MNCs in the solvent-free synthesis of new cyanopyrroloazepine derivatives and investigation of biological activity

Abstract

In this research, we synthesized the Fe 3 O 4 /CuO/ZnO@MWCNT magnetic nanocomposites using water extract of Petasites hybridus rhizome, and the high performance of synthesized catalyst was confirmed by using in the solvent-free multicomponent reactions of isatoic anhydride, N-methylimidazole, alkyl bromides, activated acetylenic compounds and 2-aminoacetonitrile at ambient temperature for the production of new cyanopyrroloazepine derivatives in high yields. This catalyst could be used several times in these reactions and have main role in the yield of product. The synthesized cyanopyrroloazepines have NH groups in their structure and for this reason have good antioxidant activity. Also, employing Gram-positive and Gram-negative bacteria in the disk diffusion procedure confirmed some cyanopyrroloazepines antimicrobial effect. The results showed that synthesized cyanopyrroloazepine prevented the bacterial growth. This used process for preparation of new cyanopyrroloazepine has some improvements such as low reaction time, product with high yields, simple separation of catalyst and products.

A comprehensive review on synthesis of dihydropyrimidione via Biginelli reaction catalyzed by reusable magnetic nanocatalyst (from 2020–till date)

“…tetrahydrobenzo [a]xanthene-11-ones [12] ; amidoalkyl naphthols [13] ; xanthene derivatives [14] ; cross-aldol condensation [15] ; 2-amino-4Hpyran derivatives [16] ; [1,3]-oxazole and 1H-pyrrolo-[1,3]-oxazole derivatives [17] ; 6-amino-5-[(4-hydroxy-2-oxo2H-chromen-3-yl)(aryl)methyl]-1,3-dimethyl-2,4,6(1H,3H)-pyrimidinedione derivatives [18] ; chromeno-pyrido[d]pyrimidine derivatives [19] ; spiro[indolequinazoline] derivatives [20] ; cyclocondensation reaction of 4-hydroxycoumarin, 3,4-methylenedioxyphenol, and aromatic aldehydes [21] ; azo chromene dyes [22] ; cyanopyrroloazepine derivatives [23] ; 1,3-dipolar cycloaddition reaction [24] ; 2,4,5-triaryl-1H-imidazoles [25] ; quinazolinone derivatives [26] ; tetrahydrobenzoxanthenones [27] ; α-aminonitriles [28] ; chromenes derivatives [29,30] ; α-aminonitriles and 2-methoxy-2-phenylacetonitrile derivative via Strecker-type reaction [31] ; dihyropyrimidiones [32] ; dihydroquinazolinone, octahydroquinazolinone, and benzimidazoloquinazolinone derivatives [33] ; quinazolines [34] ; 1-thioamidoalkyl-2-naphthols [35] ; hexahydroquinoline [36] ; benzoxanthenes [37] ; and polyhydroquinoline. [38] These reactions display high selectivity and atom economy because the final product retains nearly all of the substrates.…”

“…To develop environmentally friendly processes in green synthetic chemistry, the fusion of magnetic nanocatalysts and MCRs will emerge into a new strategic research area. Numerous studies have published research that shows combining MCRs and nanocomposites in ambient reaction circumstances provides improved results with high efficiency for organic synthesis and transformation, such as organic transformation [ 9 ] ; pyranopyrazole and pyranopyrimidine derivatives [ 10 ] ; mono and bis spiro pyrazolopyridines [ 11 ] ; tetrahydrobenzo[a]xanthene‐11‐ones [ 12 ] ; amidoalkyl naphthols [ 13 ] ; xanthene derivatives [ 14 ] ; cross‐aldol condensation [ 15 ] ; 2‐amino‐4 H pyran derivatives [ 16 ] ; [1,3]‐oxazole and 1 H ‐pyrrolo‐[1,3]‐oxazole derivatives [ 17 ] ; 6‐amino‐5‐[(4‐hydroxy‐2‐oxo2 H ‐chromen‐3‐yl)(aryl)methyl]‐1,3‐dimethyl‐2,4,6(1 H ,3 H )‐pyrimidinedione derivatives [ 18 ] ; chromeno‐pyrido[ d ]pyrimidine derivatives [ 19 ] ; spiro[indole‐quinazoline] derivatives [ 20 ] ; cyclocondensation reaction of 4‐hydroxycoumarin, 3,4‐methylenedioxyphenol, and aromatic aldehydes [ 21 ] ; azo chromene dyes [ 22 ] ; cyanopyrroloazepine derivatives [ 23 ] ; 1,3‐dipolar cycloaddition reaction [ 24 ] ; 2,4,5‐triaryl‐1 H ‐imidazoles [ 25 ] ; quinazolinone derivatives [ 26 ] ; tetrahydrobenzoxanthenones [ 27 ] ; α‐aminonitriles [ 28 ] ; chromenes derivatives [ 29,30 ] ; α‐aminonitriles and 2‐methoxy‐2‐phenylacetonitrile derivative via Strecker‐type reaction [ 31 ] ; dihyropyrimidiones [ 32 ] ; dihydroquinazolinone, octahydroquinazolinone, and benzimidazoloquinazolinone derivatives [ 33 ] ; quinazolines [ 34 ] ; 1‐thioamidoalkyl‐2‐naphthols [ 35 ] ; hexahydroquinoline [ 36 ] ; benzoxanthenes [ 37 ] ; and polyhydroquinoline. [ 38 ]…”

Enhanced Catalytic, Antioxidant, and Electrochemical Properties of Green‐Synthesized Graphene‐Silver Nanocomposite Utilizing Moringa Oleifera Leaf Extract

“…Recently organic transformations using nanocatalysts is gaining attraction due to their advantageous. [22][23][24][25][26][27] The reduction of 4-Nitrophenol (4NP) holds a paramount significance due to its pervasive toxicity in industrial effluents, posing formidable threats to both environmental integrity and biological equilibrium. [28] This catalytic conversion to 4-aminophenol (4AP) serves as a typical benchmark for evaluating the efficacy of diverse catalysts.…”

An effective and eco‐friendly sonochemical multicomponent synthesis of trisubstituted imidazoles via modified silica‐coated cobalt ferrite nanoparticles by tungstic acid

“…[9,16,17] This work is an attempt to follow green chemistry principles for the synthesis of antimicrobial and antibacterial active 2,4,5-trisubstituted imidazole derivatives. [13,14,18,19] Therefore, using a one-pot multicomponent reaction to create short synthetic route, high-atom economy, lowenergy utilization, and high selectivity [20][21][22][23] by sonochemistry employment is an essential tool for reaching this goal. The ultrasound approach as a green energy transfer technique provides the needed activation energy to synthesize target structures.…”