Employing hydrogels in tissue engineering approaches to boost conventional cancer-based research and therapies

Abstract

Hydrogels and tissue engineering showed their potential in facinating research and developement in cancer therapy.

How to build a tumor: An industry perspective

“…However, beside technical challenges related to the polymerization process the evidence for predictivity toward clinical reality of those platforms remains to be provided. 45 .…”

Development of cationic peptide-based hydrogels loaded with iopamidol for CEST-MRI detection

“…CEST agents have been investigated for many clinically relevant applications, including the possibility of labeling hydrogels (HGs), thus making them detectable by MRI. Hydrogels are supramolecular network structures able to retain a high amount of water and mainly studied as platforms to encapsulate and release bioactive compounds 8,9 or as scaffolds for supporting living cells. 10…”

“…[5][6][7] CEST agents have been investigated for many clinically relevant applications, including the possibility of labeling hydrogels (HGs), thus making them detectable by MRI. Hydrogels are supramolecular network structures able to retain a high amount of water and mainly studied as platforms to encapsulate and release bioactive compounds 8,9 or as scaffolds for supporting living cells. 10 Two strategies have been adopted to make hydrogels detectable by CEST-MRI: (i) using hydrogel building blocks bearing exchangeable spins, [11][12][13][14][15][16] and/or (ii) loading hydrogels with a CEST agent.…”

Engineering of hybrid anticancer drug-loaded polymeric nanoparticles delivery system for the treatment and care of lung cancer therapy

“…The composition of a promising antitumor drug delivery mechanism is determined by the dosage ratio of the two drugs, as well as the possible rival molecules. As a result, the significance of creating a beneficial relationship in order to preserve synergy between the different substances through conveying nanoparticles cannot be overstated (Jain et al, 2010 ; Xu et al, 2016 ; Esmaeili et al, 2021 ). Encapsulating several anticancer medications in a single nanoparticle has proven difficult due to the antitumor drugs’ distinct physicochemical properties (Rayamajhi et al, 2019 ; Long et al, 2020 ; Nguyen et al, 2020 ; Wang et al, 2020 ; Sameiyan et al, 2021 ).…”