Development of cationic peptide-based hydrogels loaded with iopamidol for CEST-MRI detection

Gregorio, Enza Di; Rosa, Elisabetta; Ferrauto, Giuseppe; Diaferia, Carlo; Gallo, Enrico; Accardo, Antonella; Terreno, Enzo

doi:10.1039/d3tb00187c

J. Mater. Chem. B

2023

DOI: 10.1039/d3tb00187c

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Development of cationic peptide-based hydrogels loaded with iopamidol for CEST-MRI detection

Enza Di Gregorio

Elisabetta Rosa

Giuseppe Ferrauto

et al.

Abstract: Peptide-based hydrogels have been recently investigated as materials for biomedical applications like tissue engineering and delivery of drugs and imaging agents. Among the synthetic peptide hydrogelators, the cationic hexapeptides Ac-K1...

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Cited by 4 publications

References 28 publications

(48 reference statements)

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Advances in peptide-based drug delivery systems

Guo,

Wang,

Wang

et al. 2024

Heliyon

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Advances in peptide-based drug delivery systems

Guo,

Wang,

Wang

et al. 2024

Heliyon

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Ultrashort Cationic Peptide Fmoc-FFK as Hydrogel Building Block for Potential Biomedical Applications

Gallo,

Diaferia,

Giordano

et al. 2023

Gels

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Fmoc-diphenylalanine (Fmoc-FF) is a low-molecular-weight peptide hydrogelator. This simple all-aromatic peptide can generate self-supporting hydrogel materials, which have been proposed as novel materials for diagnostic and pharmaceutical applications. Our knowledge of the molecular determinants of Fmoc-FF aggregation is used as a guide to design new peptide-based gelators, with features for the development of improved tools. Here, we enlarge the plethora of Fmoc-FF-based hydrogelated matrices by studying the properties of the Fmoc-FFK tripeptide, alone or in combination with Fmoc-FF. For multicomponent matrices, the relative weight ratios between Fmoc-FFK and Fmoc-FF (specifically, 1/1, 1/5, 1/10, and 1/20 w/w) are evaluated. All the systems and their multiscale organization are studied using different experimental techniques, including rheology, circular dichroism, Fourier transform infrared spectroscopy, and scanning electron microscopy (SEM). Preliminary profiles of biocompatibility for the studied systems are also described by testing them in vitro on HaCaT and 3T3-L1 cell lines. Additionally, the lysine (K) residue at the C-terminus of the Fmoc-FF moiety introduces into the supramolecular material chemical functions (amino groups) which may be useful for modification/derivatization with bioactive molecules of interest, including diagnostic probes, chelating agents, active pharmaceutical ingredients, or peptide nucleic acids.

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Advances in Hydrogel-Based Drug Delivery Systems

Liu,

Chen

2024

Gels

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Hydrogels, with their distinctive three-dimensional networks of hydrophilic polymers, drive innovations across various biomedical applications. The ability of hydrogels to absorb and retain significant volumes of water, coupled with their structural integrity and responsiveness to environmental stimuli, renders them ideal for drug delivery, tissue engineering, and wound healing. This review delves into the classification of hydrogels based on cross-linking methods, providing insights into their synthesis, properties, and applications. We further discuss the recent advancements in hydrogel-based drug delivery systems, including oral, injectable, topical, and ocular approaches, highlighting their significance in enhancing therapeutic outcomes. Additionally, we address the challenges faced in the clinical translation of hydrogels and propose future directions for leveraging their potential in personalized medicine and regenerative healthcare solutions.

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Development of cationic peptide-based hydrogels loaded with iopamidol for CEST-MRI detection

Abstract: Peptide-based hydrogels have been recently investigated as materials for biomedical applications like tissue engineering and delivery of drugs and imaging agents. Among the synthetic peptide hydrogelators, the cationic hexapeptides Ac-K1...

Cited by 4 publications

References 28 publications

Advances in peptide-based drug delivery systems

Advances in peptide-based drug delivery systems

Ultrashort Cationic Peptide Fmoc-FFK as Hydrogel Building Block for Potential Biomedical Applications

Advances in Hydrogel-Based Drug Delivery Systems

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