Employing carbon dots modified with vancomycin for assaying Gram-positive bacteria like Staphylococcus aureus

Zhong, Dan; Zhuo, Yan; Feng, Yuanjiao; Yang, Xiaoming

doi:10.1016/j.bios.2015.07.015

Cited by 118 publications

(56 citation statements)

References 48 publications

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“…In recent years, antimicrobial nanoparticles (NPs) [1], nano-sized carriers for the delivery of therapeutic agents [2] or light-responsive NPs [3][4][5] properties, their surface versatility and good biocompatibility [6][7][8][9][10][11][12][13][14]. For example, Mehta et al [11] reported that CDs, synthesized by using S. officinarum juice at 120 C, acted as excellent fluorescent probes for imaging of Escherichia coli (E. coli) bacteria.…”

Section: Introductionmentioning

confidence: 99%

Enhanced antibacterial activity of carbon dots functionalized with ampicillin combined with visible light triggered photodynamic effects

Jijie

Barras

Bouckaert

et al. 2018

Colloids and Surfaces B: Biointerfaces

109

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In the last years, carbon-based nanomaterials have attracted considerable attention in a wide range of fields, particularly in biomedicine, owing to their remarkable photo-physical and chemical properties. In this study, we demonstrate that amine-terminated carbon dots (CDs-NH) functionalized with ampicillin (AMP) offer a new perspective for antibacterial treatment. The amine-functionalized carbon dots were used as a carrier for immobilization and delivery of ampicillin (CDs-AMP) and as a visible light-triggered antibacterial material. Additionally, AMP immobilization on the CDs-NH surface improves its stability in solution as compared to free AMP. The AMP conjugated CDs platform combines the antibacterial function of AMP and conserves the intrinsic theranostic properties of CDs-NH. Therefore, the AMP immobilized onto CDs-NH surface together with the generation of moderate quantities of reactive oxygen species under visible light illumination are very effective to inactivate the growth of Escherichia coli.

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Section: Introductionmentioning

confidence: 99%

Enhanced antibacterial activity of carbon dots functionalized with ampicillin combined with visible light triggered photodynamic effects

Jijie

Barras

Bouckaert

et al. 2018

Colloids and Surfaces B: Biointerfaces

109

View full text Add to dashboard Cite

show abstract

“…Carbon nanodots or carbon quantum dots were originally discovered due to their bright fluorescence emissions as those found in conventional semiconductor quantum dots, and can also be used for drug delivery [116]. Carbon dots modified with vancomycin were proposed for the treatment of Gram-positive bacterial infections [117]. Zhong et al synthesized surface-modified carbon dots with vancomycin and successfully tested them against Bacillus subtilis, Listeria monocytogenes, Salmonella, Pseudomonas aeruginosa and Escherichia coli.…”

Section: Other Nanostructures For Amp Deliverymentioning

confidence: 99%

Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs)

et al. 2020

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Microbial infections are still among the major public health concerns since several yeasts and fungi, and other pathogenic microorganisms, are responsible for continuous growth of infections and drug resistance against bacteria. Antimicrobial resistance rate is fostering the need to develop new strategies against drug-resistant superbugs. Antimicrobial peptides (AMPs) are small peptide-based molecules of 5-100 amino acids in length, with potent and broad-spectrum antimicrobial properties. They are part of the innate immune system, which can represent a minimal risk of resistance development. These characteristics contribute to the description of these molecules as promising new molecules in the development of new antimicrobial drugs. However, efforts in developing new medicines have not resulted in any decrease of drug resistance yet. Thus, a technological approach on improving existing drugs is gaining special interest. Nanomedicine provides easy access to innovative carriers, which ultimately enable the design and development of targeted delivery systems of the most efficient drugs with increased efficacy and reduced toxicity. Based on performance, successful experiments, and considerable market prospects, nanotechnology will undoubtedly lead a breakthrough in biomedical field also for infectious diseases, as there are several nanotechnological approaches that exhibit important roles in restoring antibiotic activity against resistant bacteria.

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“…) or carbon dots (Zhong et al . ) functionalized with vancomycin. To gain specificity towards SA, Yang et al .…”

Section: Whole‐cell Detection With Biosensors Dedicated To S Aureusmentioning

confidence: 99%

“…Therefore, vancomycin could be used as a specific probe for Gram-positive bacteria, including SA. Several papers show a great potential for bacteria concentration assessment and detection thanks to magnetic beads (Kell et al 2008;Yang et al 2015) or carbon dots (Zhong et al 2015) functionalized with vancomycin. To gain specificity towards SA, Yang et al (2015) used an alkaline phosphatase-tagged antibody, which binds to protein A and magnetic beads functionalized with vancomycin.…”

Section: Vancomycinmentioning

confidence: 99%

On the challenges of detecting wholeStaphylococcus aureuscells with biosensors

Templier

Roupioz

2017

J Appl Microbiol

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SummaryDue to the increasing number of nosocomial infections and multidrug-resistant bacterial strains, Staphylococcus aureus is now a major worldwide concern. Rapid detection and characterization of this bacterium has become an important issue for biomedical applications. Biosensors are increasingly appearing as low-cost, easy-to-operate and fast alternatives for rapid detection. In this review, we will introduce the main characteristics of S. aureus and will focus on the interest of biosensors for a faster detection of whole S. aureus cells. In particular, we will review the most promising strategies in the choice of ligand for the design of selective and efficient biosensors. Their specific characteristics as well as their advantages and/or disadvantages will also be commented.

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Employing carbon dots modified with vancomycin for assaying Gram-positive bacteria like Staphylococcus aureus

Cited by 118 publications

References 48 publications

Enhanced antibacterial activity of carbon dots functionalized with ampicillin combined with visible light triggered photodynamic effects

Enhanced antibacterial activity of carbon dots functionalized with ampicillin combined with visible light triggered photodynamic effects

Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs)

On the challenges of detecting wholeStaphylococcus aureuscells with biosensors

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