2016
DOI: 10.18632/aging.101090
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Abstract: We recently selected 3 long-lived mutant strains of Saccharomyces cerevisiae by a lasting exposure to exogenous lithocholic acid. Each mutant strain can maintain the extended chronological lifespan after numerous passages in medium without lithocholic acid. In this study, we used these long-lived yeast mutants for empirical verification of evolutionary theories of aging. We provide evidence that the dominant polygenic trait extending longevity of each of these mutants 1) does not affect such key features of ea… Show more

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Cited by 9 publications
(5 citation statements)
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References 106 publications
(124 reference statements)
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“…The discovery of an intrinsic (genetic) regulation of aging-related processes has raised the not yet unresolved intellectual conflict between evolutionary theorist which debate on whether aging may represent either an evolutionary adaptive response (adaptive aging ultimately called aging by design) or not (Goldsmith, 2008;Kyryakov et al, 2016). An adaptive aging counteracts the traditional evolutionary approach which rules out the possibility of an intrinsically determined selfdefeating biological program (in terms of survival and reproduction) that does not bring about any short-or long-term benefit (non-programmed aging theory).…”
Section: Aging Cellular Senescence and Ad: A Comprehensive Overviewmentioning
confidence: 99%
“…The discovery of an intrinsic (genetic) regulation of aging-related processes has raised the not yet unresolved intellectual conflict between evolutionary theorist which debate on whether aging may represent either an evolutionary adaptive response (adaptive aging ultimately called aging by design) or not (Goldsmith, 2008;Kyryakov et al, 2016). An adaptive aging counteracts the traditional evolutionary approach which rules out the possibility of an intrinsically determined selfdefeating biological program (in terms of survival and reproduction) that does not bring about any short-or long-term benefit (non-programmed aging theory).…”
Section: Aging Cellular Senescence and Ad: A Comprehensive Overviewmentioning
confidence: 99%
“…of prolonging yeast CLS has identified lithocholic bile acid (LCA) as one of such geroprotectors (162). Yeast cells do not produce LCA or other bile acids, all of which are synthesized and released into an ecosystem by animals and humans (174)(175)(176)(177). If LCA is added exogenously to yeast cultured in a liquid medium, this highly hydrophobic bile acid enters the yeast cell, is delivered to mitochondria, accumulates mainly in the inner mitochondrial membrane (IMM) and also associates with the outer mitochondrial membrane (OMM) (178).…”
Section: Some Mitochondrial Membrane Phospholipids Define Yeast Chronmentioning
confidence: 99%
“…Unlike animals and humans, yeast cells do not synthesize bile acids [ 130 133 ]. Thus, a mechanism through which exogenously added LCA delays yeast chronological aging may or may not involve its entry into the yeast cell and, perhaps, a delivery of this highly hydrophobic bile acid to some specific location(s) within the cell.…”
Section: The Distribution Of Exogenously Added Lca Within a Yeast mentioning
confidence: 99%