2018
DOI: 10.2741/4638
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Abstract: Emergent evidence indicates that certain aspects of lipid synthesis, degradation and interorganellar transport play essential roles in modulating the pace of cellular aging in the budding yeast Saccharomyces cerevisiae. The molecular mechanisms underlying the vital roles of lipid metabolism and transport in defining yeast longevity have begun to emerge. The scope of this review is to critically analyze recent progress in understanding such mechanisms.

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Cited by 12 publications
(24 citation statements)
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“…Lipids are a vital nutrient widely utilized in almost all tissues of the body, and they play a key role in animal growth and development [21]. However, lipid transport requires special protein transporters in circulation (blood) because lipids are water-insoluble and amphiphilic [7,22]. Hence, in the present study, we first focused on genes encoding lipid transporters, including ALB, CHKA, and APOH.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Lipids are a vital nutrient widely utilized in almost all tissues of the body, and they play a key role in animal growth and development [21]. However, lipid transport requires special protein transporters in circulation (blood) because lipids are water-insoluble and amphiphilic [7,22]. Hence, in the present study, we first focused on genes encoding lipid transporters, including ALB, CHKA, and APOH.…”
Section: Discussionmentioning
confidence: 99%
“…An earlier transcriptomic analysis in chickens showed that the gene expression difference between high RFI (HRFI) and low RFI (LRFI) animals can be explained by differences in cell division, growth, proliferation and apoptosis, protein synthesis, lipid metabolism, and transport of cellular molecules [6]. Particularly, components of lipid metabolism, including fatty acid profiles, lipid transport, lipid oxidation, and enzyme activities affect feed efficiency traits [7]. Lipid transport plays an especially crucial role in lipid metabolism and involves two opposite biological processes in tissues: loading, involving energy utilization and storage, and unloading, involving endogenous synthesis and lipid release [8].…”
Section: Introductionmentioning
confidence: 99%
“…After the neutral lipids triacylglycerols (TAG) are synthesized in the endoplasmic reticulum (ER), they are stored in lipid droplets (LD) as the source of free (non-esterified) fatty acids for energy metabolism and phospholipid biosynthesis [ 68 , 69 , 70 , 71 , 72 , 73 , 74 ]. One of the characteristic traits of Q and NQ cell sub-populations formed in S. cerevisiae cultured under CR conditions is a considerable decline in TAG concentration, as compared to age-matched Q and NQ cell sub-populations developed in this yeast cultured under non-CR conditions ( Figure 2 F) [ 24 , 25 ].…”
Section: Cr Diet Alters An Age-related Chronology and Properties Omentioning
confidence: 99%
“…Cardiolipins (CL) are signature lipids of the inner mitochondrial membrane essential for the maintenance of proper morphology and functionality of yeast mitochondria [ 68 , 75 , 76 , 77 , 78 , 79 ]. Mitochondria of both Q and NQ cell sub-populations in S. cerevisiae limited in calorie supply exhibit an increase in CL concentration beginning of the PD growth phase ( Figure 2 G) [ 24 , 25 ].…”
Section: Cr Diet Alters An Age-related Chronology and Properties Omentioning
confidence: 99%
“…Lipid homeostasis is of utmost importance to maintain longevity of yeast cells and persistent deviations thereof can lead to cell demise and a phenomenon described as liponecrosis 105 179 180 181 . Several observations indicate that alterations in lipid homeostasis induce mechanisms involved in protein quality control.…”
Section: Ph Control Stress Tolerance and Longevitymentioning
confidence: 99%