Emphysema lung lobe volume reduction: effects on the ipsilateral and contralateral lobes

Brown, Matthew S.; Kim, Hee Jin; Abtin, Fereidoun; Strange, Charlie; Galperin-Aizenberg, Maya; Pais, Richard; Costa, Irene G. Da; Ordookhani, Arash; Chong, Daniel; Ni, Chiayi; McNitt-Gray, Michael F.; Tashkin, Donald P.; Goldin, Jonathan G.

doi:10.1007/s00330-012-2393-6

Cited by 44 publications

(43 citation statements)

References 35 publications

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“…4 6). The coefficients of repeatability and reproducibility of emphysema scores also decreased when using semi-automated segmentation and had ranges that varied depending on the target lobe and selected threshold of emphysema.…”

Section: Resultsmentioning

confidence: 99%

“…When emphysema affects more than 50% of the volume of one lobe and relatively spares adjacent ipsilateral lobes, the patient can benefit from bronchoscopic lung volume reduction (3). CT quantifies the severity and distribution of the disease and monitors the effects of treatment (3,4). However, the intrinsic variability of CT measures of lobar volumes and emphysema scores can potentially influence the therapeutic management of these patients (5).…”

Section: Discussionmentioning

confidence: 99%

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Intra- and interoperator variability of lobar pulmonary volumes and emphysema scores in patients with chronic obstructive pulmonary disease and emphysema: comparison of manual and semi-automated segmentation techniques

Molinari¹,

Pirronti²,

Sverzellati³

et al. 2013

Diagn Interv Radiol

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ORIGINAL ARTICLE PURPOSE We aimed to compare the intra-and interoperator variability of lobar volumetry and emphysema scores obtained by semi-automated and manual segmentation techniques in lung emphysema patients. MATERIALS AND METHODSIn two sessions held three months apart, two operators performed lobar volumetry of unenhanced chest computed tomography examinations of 47 consecutive patients with chronic obstructive pulmonary disease and lung emphysema. Both operators used the manual and semi-automated segmentation techniques. The intra-and interoperator variability of the volumes and emphysema scores obtained by semi-automated segmentation was compared with the variability obtained by manual segmentation of the five pulmonary lobes. RESULTSThe intra-and interoperator variability of the lobar volumes decreased when using semi-automated lobe segmentation 166.9 vs. 68.7; and left lower lobe, 168.7 vs. 71.6). The coefficients of repeatability and reproducibility of emphysema scores also decreased when using semi-automated segmentation and had ranges that varied depending on the target lobe and selected threshold of emphysema. CONCLUSION Semi-automated segmentation reduces the intra-and interoperator variability of lobar volumetry and provides a more objective tool than manual technique for quantifying lung volumes and severity of emphysema.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Intra- and interoperator variability of lobar pulmonary volumes and emphysema scores in patients with chronic obstructive pulmonary disease and emphysema: comparison of manual and semi-automated segmentation techniques

Molinari¹,

Pirronti²,

Sverzellati³

et al. 2013

Diagn Interv Radiol

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“…These thresholds were chosen on the basis of cluster analysis and are consistent with recent reports [21]. Group differences according to continuous data were evaluated using two-sample t-tests for one variable, and the generalised linear model for multivariate analyses.…”

Section: Discussionmentioning

confidence: 99%

Target lobe volume reduction and COPD outcome measures after endobronchial valve therapy

Valipour

Herth²,

Burghuber

et al. 2013

European Respiratory Journal

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Endobronchial valve (EBV) therapy may be associated with improvements in chronic obstructive pulmonary disease-related outcomes and may therefore be linked to improvements in the body mass index, airflow obstruction, dyspnoea, exercise capacity (BODE) index.Data from 416 patients with advanced emphysema and hyperinflation across Europe and USA, who were randomised to EBV (n5284) or conservative therapy (n5132) were analysed. Quantitative image analysis was used to compare the volume of the targeted lobe at baseline and at 6 months to determine target lobe volume reduction (TLVR).44% of patients receiving EBV therapy (versus 24.7% of controls) had clinically significant improvements in the BODE index (p,0.001). BODE index was significantly reduced by mean¡SD 1.4¡1.8, 0.2¡1.3 and 0.1¡1.3 points in patients with TLVR .50%, 20%-50% and ,20%, respectively (intergroup differences p,0.001), but increased by 0.3¡1.2 points in controls. Changes in BODE were predicted by baseline BODE and correlated significantly with lobar exclusion and lung volumes at 6 months.A greater proportion of patients in the treatment group than in the control group achieved a clinically meaningful improvement in BODE index; however, the likelihood of benefit was less than half in both groups. Patients in whom TLVR was obtained had greater improvements in clinical outcomes. Clinical trial: This study is registered at clinicaltrials.gov with identifier number NCT00129584.

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“…The upper part of regional perfusion is similar to the upper lobe of the lung, and the lower part is similar to that of the lower lobe (50). A series of studies found that BLVR would cause a decrease in target lung perfusion and increase ipsilateral non-target lobe and contralateral lung perfusion (51)(52)(53). Therefore, assessment of lobe perfusion before treatment may be an index of the success of EBV.…”

Section: Other Predictorsmentioning

confidence: 99%

Status of and prospects for bronchoscopic lung volume reduction for patients with severe emphysema

Wang

et al. 2016

BST

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Emphysema lung lobe volume reduction: effects on the ipsilateral and contralateral lobes

Cited by 44 publications

References 35 publications

Intra- and interoperator variability of lobar pulmonary volumes and emphysema scores in patients with chronic obstructive pulmonary disease and emphysema: comparison of manual and semi-automated segmentation techniques

Intra- and interoperator variability of lobar pulmonary volumes and emphysema scores in patients with chronic obstructive pulmonary disease and emphysema: comparison of manual and semi-automated segmentation techniques

Target lobe volume reduction and COPD outcome measures after endobronchial valve therapy

Status of and prospects for bronchoscopic lung volume reduction for patients with severe emphysema

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