Emphasis on Antibiotic Optimisation in Difficult to Treat Methicillin Resistant Staphylococcus Aureus Infection

Kumar, Surinder; Budhani, Diksha; Sayal, Pallavi; Sindwani, Pooja; Jain, Piyush

doi:10.14260/jemds/2017/1099

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…[ 1 2 ] Status of being methicillin resistant itself means that a S. aureus isolate will not be sensitive to Penicillins, Cephalosporins, β- lactamase inhibitors, and Carbapenems and can further exhibit resistance to other classes of antibiotics. [ 3 4 ] MRSA have been implicated in serious skin infections, necrotizing fasciitis, deep tissue abscesses, and their hematogenous spread can result in bone and joint infections, sepsis and endocarditis. [ 5 ] Drug of choice to treat these multidrug-resistant MRSA are glycopeptide antibiotics such as vancomycin.…”

Section: Introductionmentioning

confidence: 99%

Prevalence pattern of MRSA from a rural medical college of North India

Lohan¹,

Sangwan²,

Mane³

et al. 2021

Journal of Family Medicine and Primary Care

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Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) has become a global challenge. The shift of this organism form hospital settings to community setting and increasing resistance to non-β-lactams antibiotics have further aggravated the crisis. This trend in MRSA has necessitated the knowledge and sensitization about this agent among physicians in rural and peripheral settings. Material and Methods: Present study was undertaken at Department of Microbiology at rural medical college of North India from January 2017 to December 2019 (3 years). All the clinical samples collected with aseptic precautions were processed as per standard protocol. All the Staphylococcus aureus isolates cultured were subjected to antimicrobial susceptibility testing as per CLSI guidelines 2019. Screening for MRSA was done by CLSI recommended methods, such as cefoxitin disc (30 μg), oxacillin disc (1 μg), and oxacillin screen agar as per CLSI recommendation. Results: A steady increase in number of MRSA isolates was observed from year 2017 to 2019 with overall prevalence being 33.7%. Most MRSA isolates were obtained from pus samples. Cefoxitin disc diffusion method is a dependable detection method compared to oxacillin disc diffusion and oxacillin screen agar for identification of MRSA. Conclusion: The rising trend of MRSA impresses upon the acute need of stringent infection control practices namely strict compliance to hand hygiene, prevention of misuse and overuse of antibiotics and a continuous surveillance program for MRSA. Also sensitization about this agent among the primary health physician is the need of hour to implement the control measures and limit its spread in communities.

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Section: Introductionmentioning

confidence: 99%