Emotional stress-induced transient global amnesia with bilateral hippocampal ischemic lesion

Perković, Romana; Buljan, Krunoslav; Vladetić, Mirjana; Katic, Frances; Mišević, Sanja; Soldo, Silva Butković

doi:10.14412/2074-2711-2019-2-89-92

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…Клинической особенностью ТГА является внезапное возникновение симптомов амнезии, а также наличие провоцирующих факторов, таких как подъем АД, психоэмоциональный стресс, физическая нагрузка, половой акт, воздействие холода и тепла, мигрень, проба Вальсальвы [13]. При МРТ-исследованиях у пациентов с ТГА могут обнаруживаться гиперинтенсивные очаговые изменения в гиппокампальной области [14,15]. Тем не менее в настоящее время остается недостаточно изученным вопрос взаимосвязи между сосудистыми факторами риска и развитием ТГА.…”

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Differences in the Cardiovascular Risk Factor Profiles in Patients With Transient Global Amnesia and Transient Ischemic Attack

Ryabchenko

2023

Ulyanovsk Medico-biological Journal

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The purpose of the study is to examine the characteristics of cardiovascular risk factors in patients with transient global amnesia and transient ischemic attack. Materials and Methods. A study was conducted of patients with transient global amnesia and transient ischemic attack admitted to the primary vascular department, City Clinical Hospital named after N.I. Pirogov (January 2021 – March 2023). All patients were examined for main cardiovascular risk factors, such as age, male gender, coronary artery disease, atrial fibrillation, previous stroke, diabetes mellitus, smoking, arterial hypertension, dyslipidemia, increased hematocrit, left ventricular hypertrophy, valvular heart disease, and atherosclerosis of the brachiocephalic arteries. Statistical data processing was carried out with Data Analysis package, Microsolft Excel 2019. One-way ANOVA test was used to calculate statistical significance between the groups. For all data, statistical significance was p<0.05. Results. We examined 37 patients with transient global amnesia and 103 patients with transient ischemic attack. In patients with transient global amnesia, such cardiovascular risk factors as male gender, coronary artery disease, stroke, and atrial fibrillation were significantly less common, and the level of total cholesterol was significantly higher. There were no statistically significant differences in the incidence of other risk factors. Conclusion. Cardiovascular risk factor profiles differ in patients with transient global amnesia and those with transient ischemic attacks. The identified risk factors make it possible to focus on the developmental mechanisms of these pathologies and optimize primary and secondary prevention techniques.

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Differences in the Cardiovascular Risk Factor Profiles in Patients With Transient Global Amnesia and Transient Ischemic Attack

Ryabchenko

2023

Ulyanovsk Medico-biological Journal

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Transient global amnesia

Kulesh,

Demin,

Kayleva

et al. 2024

RJTAO

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Transient global amnesia (TGA) is a benign, stress-induced neurological syndrome associated with reversible hippocampal dysfunction that manifests as isolated, predominantly anterograde amnesia. Since it is impossible to make a definitive diagnosis of TGA when the patient is admitted to hospital, the primary condition should be interpreted as an acute cerebrovascular accident, which implies a mandatory neuroimaging examination and clarification of the question of thrombolysis according to general principles. When taking a medical history, attention should be paid to the presence of predisposing conditions and triggers: migraine, chronic and acute stress, physical activity, sudden changes in temperature, Valsalva maneuver, coitus, medical procedures. If amnesia does not resolve within 24 hours, a differential diagnosis with stroke, Wernicke–Korsakoff encephalopathy, limbic encephalitis, intoxication and psychogenic (dissociative) amnesia is required. If the symptoms resolve within 24 hours and the classic diagnostic criteria are met, magnetic resonance imaging of the brain in diffusion-weighted mode is performed on days 2 to 4 in order to detect pinpoint zones of diffusion restriction in the hippocampus. If these lesions are visible and a typical medical history is available, the diagnosis of TGA can be made; if no lesions are present, the diagnosis is probable. In the absence of lesions and an atypical history of TGA, differentiation from transient epileptic or dissociative amnesia and transient ischemic attack is required.

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Retrospective analysis of cases of transient global amnesia admitted to the hospital

Ryabchenko

Долгов

2023

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Introduction. Transient global amnesia (TGA) is a clinical syndrome, the main clinical manifestation of which is sudden development of anterograde and retrograde amnesia, lasting not more than 24 hours, without other general cerebral or focal neurological symptoms.The aim of the work was to reveal the peculiarities of clinical manifestations and data of additional methods of examination of patients with TGA syndrome referred to the primary vascular department with suspected acute cerebral circulation disorder (ACCD).Materials and methods. The study included 16 patients with transient global amnesia diagnosed according to the diagnostic criteria of Hodges and Warlow (1990). All patients underwent a detailed neurological and general medical examination. Electrocardiography, multispiral computer tomography of the head, echocardiography, ultrasound duplex scanning of the main arteries of the head and neck, laboratory examination (lipid spectrum) were performed. The Brief Mental Status Rating Scale was used to assess cognitive impairment.Results. The majority of patients had elevated blood pressure (BP). The leading trigger factor of transient global amnesia was stress. The duration of amnesia ranged from 1.5 to 5 hours. There was a significant impairment of short-term memory. On the first and second days of hospitalization, 50% of patients had normal cognitive functions on a brief mental status assessment scale, but by the 5th−7th day only 12.5 % of patients had abnormalities. Ultrasound markers of atherosclerosis in the form of intima-media complex thickening and dyslipidemia were found in 6 patients. Signs of left ventricular hypertrophy were found in the majority of patients. Discussion TGA is a relatively rare condition and an understudied syndrome. Due to its suddenness of clinical manifestation, TGA requires differential diagnostics with acute cerebral circulatory disorders, epilepsy, acute hypertensive encephalopathy and psychogenic amnesia.Conclusion. The clinical features of TGA identified in the patients were a history of arterial hypertension, elevated BP during an episode of TGA. The leading provoking factor was stress. TGA episode occurred predominantly in the first half of the day. The majority of patients had complaints of headache on admission. Cognitive disorders detected in patients on the first and second days of the disease quickly regressed to normal. Left ventricular hypertrophy was detected in most patients.

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Emotional stress-induced transient global amnesia with bilateral hippocampal ischemic lesion

Cited by 3 publications

References 21 publications

Differences in the Cardiovascular Risk Factor Profiles in Patients With Transient Global Amnesia and Transient Ischemic Attack

Differences in the Cardiovascular Risk Factor Profiles in Patients With Transient Global Amnesia and Transient Ischemic Attack

Transient global amnesia

Retrospective analysis of cases of transient global amnesia admitted to the hospital

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