Emotional State, Coping Styles, and Somatic Variables in Patients With Chronic Hepatitis C

Kraus, Michael R.; Schäfer, Arne; Csef, Herbert; Scheurlen, Michael; Faller, Hermann

doi:10.1176/appi.psy.41.5.377

Cited by 109 publications

(69 citation statements)

References 24 publications

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“…Patients who have chronic diseases, such as hepatitis and depression, need a higher number of consultations, which increases treatment costs. They are unable to perform daily activities and experience consequent deterioration in quality of life, a higher number of somatic complaints, difficulties adapting to aversive symptoms associated with the disease, and may be less compliant to prescribed treatment and have an increased risk of mortality (18) .…”

Section: Discussionmentioning

confidence: 99%

Convivendo com hepatite: repercussões no cotidiano do indivíduo infectado

Teston

Silva

Marcon

2013

Rev. esc. enferm. USP

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RESUMO ABSTRACTWe performed a descriptive, exploratory, and qualitative study, to identify changes in the daily life of subjects with hepatitis. The data were collected in October 2011 from 12 patients with hepatitis B and/or C, through semi-structured interview, and subjected to thematic content analysis. The majority of the subjects were diagnosed with hepatitis B. The time of diagnosis ranged from less than 6 months to 12 years, and the diagnosis was made mainly through blood donation. Only two patients were taking interferon. The results were divided into two categories that describe feelings and reactions experienced by the interviewees, as well as some lifestyle changes. It was concluded that health professionals need to be aware of the complexity of phenomena concerning the illness process and life with hepatitis. DESCRIPTORS RESUMENEstudio descriptivo, exploratorio, de abordaje cualitativo, desarrollado con el objetivo de identificar las alteraciones en el cotidiano del individuo con hepatitis. Los datos fueron recolectados en octubre de 2011 en 12 pacientes con Hepatitis B y/o C, por medio de entrevistas semiestructuradas y luego, sometidos al análisis del contenido de tipo temático. La mayoría de los individuos tenía el diagnóstico de hepatitis B. El tiempo de diagnóstico varió de menos de 6 meses hasta 12 años, y la principal forma de diagnóstico fue a través de la donación de sangre. Solamente dos de los individuos estaban usando Interferón. Los relatos dieron origen a dos categorías relacionadas con los sentimientos y reacciones vividas por los entrevistados así como alteraciones en algunos hábitos de vida. Se concluye que es necesario que los profesionales de la salud contemplen con mayor cuidado la complejidad que involucra los fenómenos concernientes al proceso de la enfermedad y la convivencia con la hepatitis. DESCRIPTORES

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Section: Discussionmentioning

confidence: 99%

Convivendo com hepatite: repercussões no cotidiano do indivíduo infectado

Teston

Silva

Marcon

2013

Rev. esc. enferm. USP

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“…Depressive symptoms often accompany diseases affecting the immune system including, but not limited to, HIV/AIDS [26], diabetes [3], multiple sclerosis [10] and cardiovascular disease [21]. Depressive symptoms are also common in patients with chronic hepatitis C viral infection (HCV) [1,9,12]. In a study of 293 patients with HCV, 35% had depression rating scale scores in the moderate-to-severe range prior to starting antiviral [interferon (IFN)-based] therapy [9].…”

Section: Introductionmentioning

confidence: 99%

Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1β and tumor necrosis factor-α

Loftis

Huckans

Ruimy

et al. 2008

Neuroscience Letters

106

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Studies suggest that cytokines have a role in the biology of depression. In this study, we evaluated depression and cytokine levels in patients with and without chronic hepatitis C (HCV) to better assess how chronic infection alters cytokines levels and may contribute to depressive symptomotology. Twenty-three adults with (n = 16) and without (n = 7) HCV were recruited through the Portland VA Medical Center. Research participants were excluded for current substance abuse, psychotic disorder, liver cirrhosis, or interferon (IFN) therapy. Participants completed the Beck Depression Inventory-II (BDI-II) and a blood draw to evaluate plasma cytokine levels [i.e., interleukin (IL)-1β, IL-10 and tumor necrosis factor (TNF)-α]. T-tests were performed to compare cytokine levels in patients with versus those without HCV. HCV patients showed higher TNF-α values compared to patients without HCV (group means = 7.94 vs. 3.41 pg/mL, respecitively, p = 0.047). There were no significant differences between the groups for the other cytokines assessed. In patients with HCV, TNF-α and IL-1β levels (but not IL-10) were correlated with BDI-II scores [r = 0.594, p = 0.020 and r = 0.489, p = 0.055 (trend), respectively]. Taken together, these results show an association between severity of depressive symptoms and expression of proinflammatory cytokines in patients with HCV. Future studies should investigate how inflammatory mediators play a role in the expression of specific Corresponding author: Jennifer M. Loftis, Ph.D., Phone: (503) ext. 57155, Fax: (503) 721-1053, Email: loftisj@ohsu.edu or Jennifer.loftis2@va.gov. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access

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“…fatigue) and was independent of disease severity and interferon treatment. Likewise, Kraus et al [10]found a 22.4% prevalence of depression and a 15.2% prevalence of anxiety among HCV-infected individuals, half of whom were former IDUs. A higher prevalence of DSM-IV psychiatric diagnoses was recently found by Yovtcheva et al [11], who examined 306 untreated HCV-infected veterans.…”

Section: Introductionmentioning

confidence: 99%

Emotional Stress, Psychosocial Variables and Coping Associated with Hepatitis C Virus and Human Immunodeficiency Virus Infections in Intravenous Drug Users

Grassi

Satriano²,

Serra³

et al. 2002

Psychother Psychosom

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Background: The increasing health problem of hepatitis C virus (HCV) infection has only recently attracted the attention of psychosocial research, especially among subjects at higher risk (e.g. intravenous drug users; IDUs). The aim of the present study was to compare emotional stress symptoms, psychosocial variables (i.e. social support, external locus of control and emotional repression) and coping strategies in HCV-seropositive, human immunodeficiency virus (HIV)-seropositive and HCV/HIV-noninfected IDUs. Methods: IDUs followed by the Infectious Diseases Outpatient clinic were enrolled in the study over a period of 1 year. HCV-positive (n = 62) and HIV-positive (n = 76) IDUs and HCV/HIV-seronegative IDUs (n = 152) completed the Brief Symptom Inventory, the Social Provision Scale, the Locus of Control scale and the affective inhibition scale of the Illness Behavior Questionnaire. Coping with illness among HCV-positive and HIV-positive subjects was assessed through a modified version of the Mental Adjustment to Cancer Scale. Results: No significant differences were found between the samples with respect to individual and interpersonal variables. HCV-positive subjects showed higher scores on several psychological stress dimensions (i.e. obsessive-compulsive, phobic anxiety, paranoid ideation, psychoticism) and lower scores on fighting spirit, hopelessness and anxious preoccupation towards illness than HIV-positive patients. HCV-positive and HCV/HIV-seronegative IDUs reported comparable scores on most of the psychological measures. Conclusions: The findings indicate that routine assessment of psychosocial variables and coping mechanisms should be integrated into all HCV and HIV services, especially those dedicated to treatment of patients with substance abuse, as a vulnerable segment of the population at risk for life-threatening physical illness such as HCV and HIV infections.

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Emotional State, Coping Styles, and Somatic Variables in Patients With Chronic Hepatitis C

Cited by 109 publications

References 24 publications

Convivendo com hepatite: repercussões no cotidiano do indivíduo infectado

Convivendo com hepatite: repercussões no cotidiano do indivíduo infectado

Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1β and tumor necrosis factor-α

Emotional Stress, Psychosocial Variables and Coping Associated with Hepatitis C Virus and Human Immunodeficiency Virus Infections in Intravenous Drug Users

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