Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1β and tumor necrosis factor-α

Loftis, Jennifer M.; Huckans, Marilyn; Ruimy, Samantha; Hinrichs, David J.; Hauser, Péter

doi:10.1016/j.neulet.2007.11.001

Cited by 107 publications

(90 citation statements)

References 28 publications

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“…32 Otherwise, the role played by the host's immune response (especially cytokine-related effects) on psychiatric disorders in CHC should not be disregarded. 33 In addition to depression, CHC has been shown to be associated with other psychiatric comorbidities that may themselves contribute to a poorer HRQOL. 4,16,34 Despite the results of multivariate analyses in this study, the influence of anxiety disorder influence on the HRQOL of patients with CHC should not be ignored.…”

Section: Discussionmentioning

confidence: 99%

Depression rather than liver impairment reduces quality of life in patients with hepatitis C

Silva

Cunha

et al. 2015

Rev. Bras. Psiquiatr.

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Objective: Patients with chronic hepatitis C (CHC) have a poorer quality of life than those with other chronic liver diseases. However, some of the factors that determine health-related quality of life (HRQOL) in these patients, such as the degree of liver fibrosis, are still controversial. Therefore, the aim of the present study was to investigate the impact of CHC on HRQOL by conducting clinical, psychiatric, and sociodemographic evaluations. Methods: One hundred and twenty-four consecutive patients attending a referral center for hepatitis were evaluated using the Mini-International Neuropsychiatry Interview, the Hamilton Depression Rating Scale, the Hospital Anxiety and Depression Scale, and the Medical Outcomes Study 36-Item Short-Form Health Survey. Multiple linear regression analyses were used to quantify independent associations between HRQOL and the clinical, psychiatric, and sociodemographic variables of interest. Results: Reduced HRQOL was independently associated with major depressive disorder (MDD) and with elevated levels of alanine aminotransferase, but was not associated with hepatic cirrhosis. Conclusions: MDD rather than the grade of liver fibrosis was strongly associated with HRQOL impairment in patients with CHC. These findings highlight that, in patients with CHC, the psychological effects of the disease deserve more attention and the implementation of integrated medical, psychiatric, and psychological care may be helpful.

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Section: Discussionmentioning

confidence: 99%

Depression rather than liver impairment reduces quality of life in patients with hepatitis C

Silva

Cunha

et al. 2015

Rev. Bras. Psiquiatr.

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“…The immunologic response and incidence of depression in NCC must be evaluated. There is a strong suggestion that cytokines have a role in the biology of depression 28 . Th1 cytokines are predominant in the immunological response elicited by Cysticercus cellusae and include gamma interferon, interleukin-18 (IL-18), and the immunosuppressive, fibrosis-promoting cytokine transforming growth factor beta.…”

Section: Discussionmentioning

confidence: 99%

Frequency of depression among patients with neurocysticercosis

Almeida

Gurjão

2010

Arq. Neuro-Psiquiatr.

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Neurocysticercosis (NCC) is a common central nervous system infection caused by Taenia solium metacestodes. Objective: To investigate the occurrence of depression in patients with calcified NCC form. The study group consisted of 114 patients subdivided in four groups: NCC with epilepsy, NCC without epilepsy, epilepsy without NCC and chronic headache. Method: Depression was evaluated and quantified by the Hamilton Rating Scale for Depression (HRSD-21). results: Percentage of patients with depression was as follows: group 1 (83%); group 2 (88%); group 3 (92%); group 4 (100%). The majority of patients had moderate depression. conclusion: Incidence of depression in all groups was higher than in the general population. It is possible that, in a general way, patients with chronic diseases would have depression with similar intensity. NCC is associated with the presence of depression. Key words: depression, neurocysticercosis, psychiatric disturbs, infectious diseases, neuroinfection.Depressão em pacientes portadores de neurocisticercose resuMO Neurocysticercose (NCC) é uma infecção do sistema nervoso central comum causada por metacestodes da Taenia solium. Objetivo: investigar a ocorrência de depressão nos pacientes com NCC forma calcificada. O grupo de estudo é formado por 114 pacientes subdivididos em quatro grupos: NCC com epilepsia, NCC sem epilepsia, epilepsia sem NCC e cefaléia crônica. Método: A presença de depressão foi determinada e quantificada pela Escala de Depressão de Hamilton (HRSD-21). resultados: A porcentagem de pacientes com depressão foi: grupo 1 (83%); grupo 2 (88%); grupo 3 (92%); grupo 4 (100%). A maioria dos pacientes apresentou depressão moderada. conclusão: A incidência da depressão em todos os grupos foi mais elevada do que na população geral, contudo não houve diferença entre os grupos estudados. É possível que, de uma maneira geral, os pacientes portadores de doença crônica apresentarem a depressão em intensidade similar. NCC está associada com a presença de depressão. Palavras-chave: depressão, distúrbios psiquiátricos, doenças infecciosas, neurocisticercose, neuroinfecção. Correspondence

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“…some interleukins) activated by IFN-α can play a role in the induction of depressive symptoms involving the serotoninergic system, hypothalamic-pituitarythyroid axis, and the cytokine network. [37][38] The relationship between ferritin and depression has rarely been studied. 39 Some reports indicated that chronic hemodialysis patients with major depression had higher ferritin levels.…”

Section: Discussionmentioning

confidence: 99%

Quality of life, depression, and cytokine patterns in patients with chronic hepatitis C treated with antiviral therapy

Falasca

Mancino²,

Ucciferri³

et al. 2009

CIM

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Clin Invest Med 2009; 32 (3): E212-E218. AbstractPurpose: To evaluate the effect of chronic hepatitis C and antiviral therapy on health-related quality of life (HRQoL), depression symptoms and cytokine patterns. Methods: Twenty HCV+ patients treated with peginterferon plus ribavirin were enrolled in this cohort study and invited to complete SF-12 and BDI questionnaires prior to (T0) and at the end of the treatment (T1). HCV-RNA, serum levels of ALT, AST, haemoglobin, ferritin and IFN-γ, TNF-α, IL-2, IL-4, IL-6 and IL-10 were evaluated at T0 and T1. The questionnaire results were correlated to biochemical and cytokine parameters. Results: Two patients (1%) dropped out and 18 HCV patients composed the final sample (11 males (61.1%); mean age 42.5±11.9 yr; mean disease duration 9.7±6.9 yr). Between T0 and T1 ALT (p=0.02), AST (p=0.052) HCV-RNA (P=0.0002) and haemoglobin levels decreased (p=0.0003), whereas ferritin level increased (P=0.003). Also, at T1 all cytokine levels were augmented. Regarding depression status, at T0 10 patients (55.5%) scored above to the BDI questionnaire (suggesting clinically significant depression), whereas at T1 14 patients scored 10 or above (77.7%). At T1 the mean BDI score increased, but this difference was not significant. Regarding HRQoL, the majority of patients had T0 summary scores ≤ 50. At T1 HRQoL changed and scores decreased in 66.7% of the patients.A correlation was observed between the T0 level of ferritin and the amount of change in BDI and SF-12 mental score between T0 and T1 (Spearman rho = -0.56 and +0.61, respectively) and IL-4 level at T0 and the change in BDI and SF-12 mental scores (Spearman rho = -0.49 and +0.45, respectively). Conclusion: BDI, SF-12, IL-4 and ferritin are good tools to predict the appearance of depressive symptoms and worsening of the quality of life in the HCV+ population.Hepatitis C virus (HCV) infection is the major cause of chronic liver disease worldwide leading 60% up to 80% of patients to develop a chronic infection 1 and is the primary indication for liver transplantion worldwide. This economic burden is multiplied by the dramatic impact of HCV on health related quality of life (HRQoL) resulting from complications of advanced liver disease. 2 On the other hand, evolving data indicate that HCV itself may diminish HRQoL in the absence of advanced liver disease 2 , perhaps as a result of extrahepatic symptoms related to HCV, cognitive dysfunction related to HCV, or a negative synergy between HCV and comorbid psychosocial disorders. 3 ORIGINAL RESEARCH

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Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1β and tumor necrosis factor-α

Cited by 107 publications

References 28 publications

Depression rather than liver impairment reduces quality of life in patients with hepatitis C

Depression rather than liver impairment reduces quality of life in patients with hepatitis C

Frequency of depression among patients with neurocysticercosis

Quality of life, depression, and cytokine patterns in patients with chronic hepatitis C treated with antiviral therapy

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