“…The unadjusted observed relationship between depressive symptoms and glycemic control is linear throughout the complete range of observed BDI scores. This come in concordance with numerous cross sectional studies, [14][15][16][17] as well as a meta-analysis of 30 studies found depression is associated with suboptimal glycemic control with moderate effect size. 18 Although there many demographic, and clinical variables could influence glycemic control, the adjustment of this observed relationship for various demographic and clinical variables had weakened the relation but not eliminate it, after full adjustment only the major depressive disorder (MDD), and BDI scores higher than 25, but not the full range, were significant predictors for higher HbA1c (p= 0.034, and 0.046 respectively), which come in concordance with IDEA Tel study on elderly patients which found a significant correlation between depression and HbA1c at base line and a trend for depression to predict HbA1c when other factors were controlled.…”