Emotion recognition in unaffected first-degree relatives of individuals with first-episode schizophrenia

Allott, Kelly; Rice, Simon; Bartholomeusz, Cali F.; Klier, Claudia M.; Schlögelhofer, Monika; Schäfer, Miriam R.; Amminger, G. Paul

doi:10.1016/j.schres.2014.12.010

Cited by 57 publications

(41 citation statements)

References 49 publications

(126 reference statements)

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“…A recent meta‐analysis of 29 studies found moderate effect sizes in healthy first‐degree family members of patients with schizophrenia across a range of social cognition tasks, notably tapping mentalizing, emotional processing, and social perception abilities [Lavoie et al, ]. Allott et al [] reported deficits in recognition of anger and surprise in first‐episode schizophrenia patients and a similar deficit in healthy first degree relatives of patients versus controls. However, as in many studies employing novel language‐related phenotypes, the sample sizes were relatively small (N patients = 30, N first‐degree relatives = 27, N controls = 30).…”

Section: The Genomics Of Languagementioning

confidence: 99%

An examination of the language construct in NIMH's research domain criteria: Time for reconceptualization!

Elvevåg

Cohen

Wolters

et al. 2016

American J of Med Genetics Pt B

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The National Institute of Mental Health's Research Domain Criteria (RDoC) Initiative “calls for the development of new ways of classifying psychopathology based on dimensions of observable behavior.” As a result of this ambitious initiative, language has been identified as an independent construct in the RDoC matrix. In this article, we frame language within an evolutionary and neuropsychological context and discuss some of the limitations to the current measurements of language. Findings from genomics and the neuroimaging of performance during language tasks are discussed in relation to serious mental illness and within the context of caveats regarding measuring language. Indeed, the data collection and analysis methods employed to assay language have been both aided and constrained by the available technologies, methodologies, and conceptual definitions. Consequently, different fields of language research show inconsistent definitions of language that have become increasingly broad over time. Individually, they have also shown significant improvements in conceptual resolution, as well as in experimental and analytic techniques. More recently, language research has embraced collaborations across disciplines, notably neuroscience, cognitive science, and computational linguistics and has ultimately re‐defined classical ideas of language. As we move forward, the new models of language with their remarkably multifaceted constructs force a re‐examination of the NIMH RDoC conceptualization of language and thus the neuroscience and genetics underlying this concept. © 2016 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc.

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Section: The Genomics Of Languagementioning

confidence: 99%

An examination of the language construct in NIMH's research domain criteria: Time for reconceptualization!

Elvevåg

Cohen

Wolters

et al. 2016

American J of Med Genetics Pt B

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“…Affective features of schizophrenia, which may represent extremes of the dimensions highlighted above, have been related to amygdala function and circuitry [Aleman and Kahn, ; Gur et al, 2007a,b]. Individuals with schizophrenia are impaired in facial affect perception [Heimberg et al, ; Edwards et al, ; Gur et al, ; Kohler et al, ; Allott et al, ], especially for threat‐related expressions of anger and fear [Evangeli and Broks, ; Edwards et al, ; Kohler et al, ]. These deficits are associated with severity of negative symptoms [Gur et al, , ].…”

Section: Schizophreniamentioning

confidence: 99%

Social cognition as an RDoC domain

Gur

2015

American J of Med Genetics Pt B

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While the bulk of research into neural substrates of behavior and psychopathology has focused on cognitive, memory and executive functions, there has been a recent surge of interest in emotion processing and social cognition, manifested in designating Social Cognition as a major RDoC domain. We describe the origins of this field’s influence on cognitive neuroscience and highlight the most salient findings leading to the characterization of the “social brain” and the establishments of parameters that quantify normative and aberrant behaviors. Such parameters of behavior and neurobiology are required for a potentially successful RDoC construct, especially if heritability is established, because of the need to link with genomic systems. We proceed to illustrate how a social cognition measure can be used within the RDoC framework by presenting a task of facial emotion identification. We show that performance is sensitive to normative individual differences related to age and sex and to deficits associated with schizophrenia and other psychotic disorders. Neuroimaging studies with this task demonstrate that it recruits limbic and frontal regulatory activation in healthy samples as well as abnormalities in psychiatric populations. Evidence for its heritability was documented in genomic family studies and in patients with the 22q11.2 deletion syndrome. Measures that meet such criteria can help build translational bridges between cellular molecular mechanisms and behavior that elucidate aberrations related to psychopathology. Such links will transcend current diagnostic classifications and ultimately lead to a mechanistically based diagnostic nomenclature. Establishing such bridges will provide the elements necessary for early detection and scientifically grounded intervention.

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“…First, cognitive information processing difficulties are seen in high-risk children and unaffected family members, suggesting an inherited origin for this cognitive deficiency ( Egan et al, 2000 ). Siblings, albeit to a lesser degree than patients, present with difficulties on a wide array of cognitive tasks ( Peeters et al, 2015 , Wagshal et al, 2015 ), including working memory tasks ( Bendfeldt et al, 2015 , Zhang et al, 2016 , Schneider et al, 2017 ), attention ( Chirio et al, 2010 ), language ( Rajarethinam et al, 2011 ) and facial expression recognition ( Allott et al, 2015 , Cao et al, 2016 , Spilka and Goghari, 2017 ). This is one of the pieces of evidence for the genetic basis of neuropsychological disturbances occurring in schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Abnormal neural hierarchy in processing of verbal information in patients with schizophrenia

Lerner

Bleich-Cohen

Solnik-Knirsh

et al. 2018

NeuroImage: Clinical

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Previous research indicates abnormal comprehension of verbal information in patients with schizophrenia. Yet the neural mechanism underlying the breakdown of verbal information processing in schizophrenia is poorly understood. Imaging studies in healthy populations have shown a network of brain areas involved in hierarchical processing of verbal information over time. Here, we identified critical aspects of this hierarchy, examining patients with schizophrenia. Using functional magnetic resonance imaging, we examined various levels of information comprehension elicited by naturally presented verbal stimuli; from a set of randomly shuffled words to an intact story. Specifically, patients with first episode schizophrenia (N = 15), their non-manifesting siblings (N = 14) and healthy controls (N = 15) listened to a narrated story and randomly scrambled versions of it. To quantify the degree of dissimilarity between the groups, we adopted an inter-subject correlation (inter-SC) approach, which estimates differences in synchronization of neural responses within and between groups. The temporal topography found in healthy and siblings groups were consistent with our previous findings – high synchronization in responses from early sensory toward high order perceptual and cognitive areas. In patients with schizophrenia, stimuli with short and intermediate temporal scales evoked a typical pattern of reliable responses, whereas story condition (long temporal scale) revealed robust and widespread disruption of the inter-SCs. In addition, the more similar the neural activity of patients with schizophrenia was to the average response in the healthy group, the less severe the positive symptoms of the patients. Our findings suggest that system-level neural indication of abnormal verbal information processing in schizophrenia reflects disease manifestations.

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Emotion recognition in unaffected first-degree relatives of individuals with first-episode schizophrenia

Cited by 57 publications

References 49 publications

An examination of the language construct in NIMH's research domain criteria: Time for reconceptualization!

An examination of the language construct in NIMH's research domain criteria: Time for reconceptualization!

Social cognition as an RDoC domain

Abnormal neural hierarchy in processing of verbal information in patients with schizophrenia

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