Emodin-Conjugated PEGylation of Fe3O4 Nanoparticles for FI/MRI Dual-Modal Imaging and Therapy in Pancreatic Cancer

Ren, Shuai; Song, Lina; Tian, Ying; Zhu, Li; Guo, Kai; Zhang, Huifeng; Wang, Zhongqiu

doi:10.2147/ijn.s335588

Cited by 20 publications

(8 citation statements)

References 54 publications

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“…I have read a study entitled “Emodin-Conjugated PEGylation of Fe 3 O 4 Nanoparticles for FI/MRI Dual-Modal Imaging and Therapy in Pancreatic Cancer” in International Journal of Nanomedicine . 1 This study showed Emodin-Conjugated Fe 3 O 4 Nanoparticles can be applied for pancreatic cancer imaging and therapy. There may be several issues requiring attention.…”

Section: Dear Editormentioning

confidence: 80%

Comments on “Emodin-Conjugated PEGylation of Fe3O4 Nanoparticles for FI/MRI Dual-Modal Imaging and Therapy in Pancreatic Cancer” [Letter]

Wang¹

2022

IJN

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Section: Dear Editormentioning

confidence: 80%

Comments on “Emodin-Conjugated PEGylation of Fe3O4 Nanoparticles for FI/MRI Dual-Modal Imaging and Therapy in Pancreatic Cancer” [Letter]

Wang¹

2022

IJN

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“…These characteristic peaks of OA-IONP were also observed from both the spectra of lipid mix and Lipo-IONP. However, another characteristic peak at 1100 cm −1 attributed to the stretching vibration of “–C–O–C–” and “PO 2 “ of the DPPC and DSPE-P2000 were identified from the spectra of lipid mix and Lipo-IONP [ 28 , 29 , 30 ]. Overall, these data evidenced the co-presence of DPPC and DSPE-P2000 mix with the OA-IONP in the synthesized Lipo-IONP.…”

Section: Resultsmentioning

confidence: 99%

Liposomal Iron Oxide Nanoparticles Loaded with Doxorubicin for Combined Chemo-Photothermal Cancer Therapy

et al. 2023

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Iron oxide nanoparticle (IONP) possesses unique advantages over other nanoparticles in the use of cancer imaging and therapy. Specifically, it has drawn great attention in the emerging research field of photothermal cancer therapy. Herein, we developed doxorubicin (DOX)-loaded liposomal IONP (Lipo-IONP/DOX) and evaluated in vitro and in vivo their applicability for combined chemo-photothermal cancer therapy. The Lipo-IONP was synthesized by the thin-film evaporation method. The prepared Lipo-IONP was observed as about a 240 nm-sized agglomerate of globular-shaped nanoparticles. The TEM and FT-IR data evidenced the successful formation of liposomal IONP. The superparamagnetic property of the Lipo-IONP was confirmed by the SQUID analysis. The DSC data showed a transition temperature of about 47–48 °C for the mixed lipids composing the Lipo IONP, and the DOX release studies revealed the feasibility of induced burst release of DOX by laser irradiation. The Lipo-IONP/DOX possessed a plasma half-life of 42 min, which could ensure sufficient circulation time for magnetic tumor targeting. The in vivo magnetic targeting enabled a significant increase (6.3-fold) in the tumor accumulation of Lipo-IONP/DOX, leading to greater photothermal effects. Finally, the preliminary efficacy study evidenced the applicability as well as the safety of the Lipo-IONP/DOX for use in combined chemo-photothermal cancer therapy. Overall, the study results demonstrated that the Lipo-IONP/DOX might serve as an effective and safe agent for combined chemo-photothermal cancer therapy.

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“…Ren et al. 161 developed a multimodified Fe 3 O 4 nanoplatform (Fe 3 O 4 –PEG–Cy7–EMO), in which the Fe 3 O 4 coated with oleic acid was conjugated with PEG‐phospholipid and covalently grafted to GFLG–EMO and Cy7–NHS. These nanoparticles were shown to kill pancreatic cancer cells by FI/MRI dual‐mode imaging in combination with chemotherapy.…”

Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning

confidence: 99%

“…Simultaneously, these organic materials can introduce various functional groups on the surface of Fe 3 O 4 nanoparticles for further multifunctional modifications, such as oleic acid and PEG. Ren et al 161 . developed a multimodified Fe 3 O 4 nanoplatform (Fe 3 O 4 –PEG–Cy7–EMO), in which the Fe 3 O 4 coated with oleic acid was conjugated with PEG‐phospholipid and covalently grafted to GFLG–EMO and Cy7–NHS.…”

Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning

confidence: 99%

Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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Cancer is a complex disease associated with a combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment and diagnosis for cancer, current treatment strategies simultaneously focus on various tumor targets. Based on the rapid development of nanotechnology, nanocarriers have been shown to exhibit excellent potential for cancer therapy. Compared with nanoparticles with single functions, multifunctional nanoparticles are believed to be more aggressive and potent in the context of tumor targeting. However, the development of multifunctional nanoparticles is not simply an upgraded version of the original function, but involves a sophisticated system with a proper backbone, optimized modification sites, simple preparation method, and efficient function integration. Despite this, many well‐designed multifunctional nanoparticles with promising therapeutic potential have emerged recently. Here, to give a detailed understanding and analyzation of the currently developed multifunctional nanoparticles, their platform structures with organic or inorganic backbones were systemically generalized. We emphasized on the functionalization and modification strategies, which provide additional functions to the nanoparticle. We also discussed the application combination strategies that were involved in the development of nanoformulations with functional crosstalk. This review thus provides an overview of the construction strategies and application advances of multifunctional nanoparticles.

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Emodin-Conjugated PEGylation of Fe3O4 Nanoparticles for FI/MRI Dual-Modal Imaging and Therapy in Pancreatic Cancer

Cited by 20 publications

References 54 publications

Comments on “Emodin-Conjugated PEGylation of Fe3O4 Nanoparticles for FI/MRI Dual-Modal Imaging and Therapy in Pancreatic Cancer” [Letter]

Comments on “Emodin-Conjugated PEGylation of Fe3O4 Nanoparticles for FI/MRI Dual-Modal Imaging and Therapy in Pancreatic Cancer” [Letter]

Liposomal Iron Oxide Nanoparticles Loaded with Doxorubicin for Combined Chemo-Photothermal Cancer Therapy

Multifunctional nanoparticle for cancer therapy

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