Emerging Trends in CRF02_AG Variants Transmission Among Men Who Have Sex With Men in Spain

Bracho, María Alma; Sentandreu,; Alastrué, Ignacio; Belda, J; Juan, Amparo; Fernández‐García, Elena; Santos, Catarina L.; Zafra, T; Tasa, Teresa; Colomina, S; Gónzález-Candelas, Fernando

doi:10.1097/01.qai.0000435602.73469.56

Cited by 8 publications

(7 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Europe, CRF02_AG has previously been more commonly identified in African immigrants. However, the strain has been recently described among multicultural MSM transmission networks in Spain (Bracho et al 2014) and in France (Tamalet et al 2015). In our study, while risk behavior information was only available for a subset of individuals, we found no evidence for MSM transmission among CRF02_AG or other non-B subtypes.…”

Section: Discussionmentioning

confidence: 99%

Rising prevalence of non-B HIV-1 subtypes in North Carolina and evidence for local onward transmission

et al. 2017

View full text Add to dashboard Cite

HIV-1 diversity is increasing in North American and European cohorts which may have public health implications. However, little is known about non-B subtype diversity in the southern United States, despite the region being the epicenter of the nation’s epidemic. We characterized HIV-1 diversity and transmission clusters to identify the extent to which non-B strains are transmitted locally. We conducted cross-sectional analyses of HIV-1 partial pol sequences collected from 1997 to 2014 from adults accessing routine clinical care in North Carolina (NC). Subtypes were evaluated using COMET and phylogenetic analysis. Putative transmission clusters were identified using maximum-likelihood trees. Clusters involving non-B strains were confirmed and their dates of origin were estimated using Bayesian phylogenetics. Data were combined with demographic information collected at the time of sample collection and country of origin for a subset of patients. Among 24,972 sequences from 15,246 persons, the non-B subtype prevalence increased from 0% to 3.46% over the study period. Of 325 persons with non-B subtypes, diversity was high with over 15 pure subtypes and recombinants; subtype C (28.9%) and CRF02_AG (24.0%) were most common. While identification of transmission clusters was lower for persons with non-B versus B subtypes, several local transmission clusters (≥3 persons) involving non-B subtypes were identified and all were presumably due to heterosexual transmission. Prevalence of non-B subtype diversity remains low in NC but a statistically significant rise was identified over time which likely reflects multiple importation. However, the combined phylogenetic clustering analysis reveals evidence for local onward transmission. Detection of these non-B clusters suggests heterosexual transmission and may guide diagnostic and prevention interventions.

show abstract

Section: Discussionmentioning

confidence: 99%

Rising prevalence of non-B HIV-1 subtypes in North Carolina and evidence for local onward transmission

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Information about country of origin and likely route of HIV transmission was recorded with patients' consent. Sequences included the complete PR and the first 1005 nucleotides (335 amino acids) of the RT, and were obtained through viral RNA extraction followed by RT-PCR and direct sequencing using amplification and sequencing procedures as described previously [7,8]. Sequences were subtyped using REGAv3 [9] and COMET (http:// comet.retrovirology.lu/).…”

Section: Methodsmentioning

confidence: 99%

Expansion of the CRF19_cpx Variant in Spain

Patiño-Galindo

Torres-Puente

Gimeno

et al. 2015

Journal of Clinical Virology

Self Cite

View full text Add to dashboard Cite

“…Sequences were obtained for a 728‐nucleotide‐long region from the pol gene, comprising partial protease (Codons 10 to 99) and reverse transcriptase (Codons 1 to 152) genes. To establish the relationship between viruses obtained from the donor and the infected recipients, a phylogenetic analysis was carried out as described before …”

Section: Methodsmentioning

confidence: 99%

“…To establish the relationship between viruses obtained from the donor and the infected recipients, a phylogenetic analysis was carried out as described before. 12…”

Section: Phylogenetic Analysismentioning

confidence: 99%

Transmission of human immunodeficiency virus Type‐1 by fresh‐frozen plasma treated with methylene blue and light

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

Emerging Trends in CRF02_AG Variants Transmission Among Men Who Have Sex With Men in Spain

Cited by 8 publications

References 32 publications

Rising prevalence of non-B HIV-1 subtypes in North Carolina and evidence for local onward transmission

Rising prevalence of non-B HIV-1 subtypes in North Carolina and evidence for local onward transmission

Expansion of the CRF19_cpx Variant in Spain

Transmission of human immunodeficiency virus Type‐1 by fresh‐frozen plasma treated with methylene blue and light

Contact Info

Product

Resources

About