Expansion of the CRF19_cpx Variant in Spain

Patiño-Galindo, Juan Ángel; Torres-Puente, Manuela; Gimeno, Concepción; Ortega, Enrique; Navarro, David; Galindo, Marı́a José; Navarro, Laura; Navarro, Vicente; Juan, Amparo; Belda, J; Bracho, María Alma; Candelas, Fernando González

doi:10.1016/j.jcv.2015.06.094

Cited by 13 publications

(10 citation statements)

References 16 publications

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“…We also detected two other transmission clusters of smaller size (n = 5 and n = 4) affecting Spanish-native MSMs of another highly pathogenic variant (CRF19_cpx), which we previously reported as the first evidence of expansion of this variant outside Cuba 37 . Despite the prevalence of these CRFs remaining low in the CV, the effective expansion of these highly pathogenic HIV variants, evidenced by the detection of transmission clusters, is of especial interest because it may hamper the control of the local HIV epidemic, especially among vulnerable populations such as IDUs or MSMs.…”

Section: Discussionsupporting

confidence: 60%

The molecular epidemiology of HIV-1 in the Comunidad Valenciana (Spain): analysis of transmission clusters

Patiño-Galindo

Torres-Puente

Bracho

et al. 2017

Sci Rep

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HIV infections are still a very serious concern for public heath worldwide. We have applied molecular evolution methods to study the HIV-1 epidemics in the Comunidad Valenciana (CV, Spain) from a public health surveillance perspective. For this, we analysed 1804 HIV-1 sequences comprising protease and reverse transcriptase (PR/RT) coding regions, sampled between 2004 and 2014. These sequences were subtyped and subjected to phylogenetic analyses in order to detect transmission clusters. In addition, univariate and multinomial comparisons were performed to detect epidemiological differences between HIV-1 subtypes, and risk groups. The HIV epidemic in the CV is dominated by subtype B infections among local men who have sex with men (MSM). 270 transmission clusters were identified (>57% of the dataset), 12 of which included ≥10 patients; 11 of subtype B (9 affecting MSMs) and one (n = 21) of CRF14, affecting predominately intravenous drug users (IDUs). Dated phylogenies revealed these large clusters to have originated from the mid-80s to the early 00 s. Subtype B is more likely to form transmission clusters than non-B variants and MSMs to cluster than other risk groups. Multinomial analyses revealed an association between non-B variants, which are not established in the local population yet, and different foreign groups.

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Section: Discussionsupporting

confidence: 60%

The molecular epidemiology of HIV-1 in the Comunidad Valenciana (Spain): analysis of transmission clusters

Patiño-Galindo

Torres-Puente

Bracho

et al. 2017

Sci Rep

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“…This makes recombination events more plausible. On the other hand, CRF19_cpx spread was observed in southern Spain, where several transmission networks of young native Spanish MSM were determined, with tMRCAs in the period from 2007 to 2010 [36][37][38]. This, coupled with the recent characterization of new recombinant forms of subtypes B and G described in Spain and Portugal, could suggest that the URF identified in this study might also have originated in Europe [39,40].…”

Section: Discussionsupporting

confidence: 48%

HIV-1 Unique Recombinant Forms Identified in Slovenia and Their Characterization by Near Full-Length Genome Sequencing

Lunar

Mlakar

Zorec

et al. 2020

Viruses

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Surveillance of HIV circulating recombinant forms (CRFs) is important because HIV diversity can affect various aspects of HIV infection from prevention to diagnosis and patient management. A comprehensive collection of pol sequences obtained from individuals diagnosed with HIV-1 from 2000 to 2016 in Slovenia was subtyped to identify possible unique recombinant forms (URFs). Selected samples were subjected to near full-length genome (NFLG) sequencing and detailed recombination analyses. Discordant subtyping results were observed for 68/387 (17.6%) sequences and 20 sequences were identified as the most probable URFs and selected for NFLG characterization. Further, 11 NFLGs and two sequences of >7000 base pairs were obtained. Seven sequences were identified as “pure” subtypes or already characterized CRFs: subtype B (n = 5), sub-subtype A6 (n = 1), and CRF01_AE (n = 1). The remaining six sequences were determined to be URFs; four displayed a single recombination event and two exhibited a complex recombination pattern involving several subtypes or CRFs. Finally, three HIV strains were recognized as having epidemic potential and could be further characterized as new CRFs. Our study shows that the identification of new CRFs is possible, even in countries where HIV diversity is considered limited, emphasizing the importance of the surveillance of HIV recombinant forms.

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“…As far as we know, this study reports the largest cohort of HIV-1 CRF19_cpx outside Cuba. Although the spread of this recombinant outside Cuba has been previously described [ 10 – 11 ], it is the first time arising as an outbreak of such size. CRF19_cpx has been sampled in our area since 2011, with an estimated introduction in 2009.…”

Section: Discussionmentioning

confidence: 99%

“…As mentioned, and despite the very low spread of the CRF19_cpx variant outside Cuba, the existence of a few cases of this recombinant form was recently reported in Tunisia and Spain [ 10 – 11 ]. The United Kingdom, Greece and France are also represented, with certain sequences in the LANL (48, 2 and 1 sequences, respectively; last accessed in January 2017).…”

Section: Introductionmentioning

confidence: 99%

Emergence as an outbreak of the HIV-1 CRF19_cpx variant in treatment-naïve patients in southern Spain

et al. 2018

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Expansion of the CRF19_cpx Variant in Spain

Cited by 13 publications

References 16 publications

The molecular epidemiology of HIV-1 in the Comunidad Valenciana (Spain): analysis of transmission clusters

The molecular epidemiology of HIV-1 in the Comunidad Valenciana (Spain): analysis of transmission clusters

HIV-1 Unique Recombinant Forms Identified in Slovenia and Their Characterization by Near Full-Length Genome Sequencing

Emergence as an outbreak of the HIV-1 CRF19_cpx variant in treatment-naïve patients in southern Spain

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