Emerging therapies for the treatment of ungual onychomycosis

Kushwaha, Avadhesh; Murthy, Reena N; Murthy, S. Narasimha; Elkeeb, Rania; Hui, Xiaoying; Maibach, Howard I.

doi:10.3109/03639045.2015.1033426

Cited by 25 publications

(31 citation statements)

References 35 publications

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“…Early diagnosis of fungal infections is necessary to the appropriate decision of the antifungal therapy of election because some organisms are less likely to respond to certain antifungal agents. In fact, therapies for the treatment of ungual onychomycosis are different depending on the location of infection and infectious agents (yeast, dermatophytes and non‐dermatophytic moulds) . Therefore, accurate diagnosis of onychomycosis before treatment initiation, based on both clinical and laboratory examinations, may help the clinician to select the most proper therapy decreasing not only the clinical symptoms but also the economic loss due to expensive antimycotic therapy.…”

Section: Discussionmentioning

confidence: 99%

Non‐dermatophytic onychomycosis diagnostic criteria: an unresolved question

Bombace

Iovene

Galdiero

et al. 2016

Mycoses

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Non-dermatophytic moulds (NDMs) have been increasingly recognised as causative agents of onychomycosis. The diagnosis of onychomycosis is most often obtained by microscopic observation of nail specimens where fungal elements can be detected and cultured by standard mycological techniques. Direct microscopic examination does not always result positive in NDM onychomycosis; therefore to perform a correct diagnosis, a proper mycological culture is often required. The purpose of our study was to evaluate the role of direct microscopic examination in the NDM onychomycosis diagnosis. The results show that only 57.2% of the specimens from onychomycosis patients could be properly diagnosed showing positivity to both direct microscopic examination and NDMs culture isolation in two or more subsequent inoculations, while 42.8% of analysed specimens with a negative direct microscopic examination, showed NDMs growth after three or more subsequent inoculations. The large proportion of false negatives (more than 42%) could be related to the duration of the infection and/or to the experience and skills of the personnel dedicated to specimen collection. We point out the need for thoroughly evaluating all specimens showing cultural growth in at least three subsequent medium inoculations, whatever the result of the microscopic examination, in order to reduce false-negative rates. This strategy would allow for more accurate diagnosis of this mycosis.

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Section: Discussionmentioning

confidence: 99%

Non‐dermatophytic onychomycosis diagnostic criteria: an unresolved question

Bombace

Iovene

Galdiero

et al. 2016

Mycoses

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“…51 Nail plate excision and matricectomy are only rarely performed in selected cases. 16,52 In recent years, various laser devices include neodymium-doped yttrium aluminum garnet (Nd:YAG), diode, carbon dioxide (CO 2 ), and Erbium:glass (Er:Glass) have been used as an alternative modality for onychomycosis. Their mechanism of action is not yet exactly known.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Acral manifestations of fungal infections

Kutlubay

Yardımcı

Kantarcıoğlu

et al. 2017

Clinics in Dermatology

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“…In vivo studies employing brain microdialysis in rats demonstrated that intranasal administration of NGF formulation with 0.5% peppermint oil enhanced the bioavailability by ∼8 fold compared to rats administered with NGF alone [24][25][26]. The bioavailability of NGF in the brain could be enhanced by intranasal administration of peppermint oil.…”

Section: Alteration Of Membrane Permeability Using Permeation Enhancersmentioning

confidence: 99%