Acral manifestations of fungal infections

Kutlubay, Zekayі; Yardımcı, Gürkan; Kantarcıoğlu, A. Serda; Serdaroğlu, Server

doi:10.1016/j.clindermatol.2016.09.005

Cited by 9 publications

(3 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fungal infections of humans are widespread and can appear in many different forms. Infections of the skin and nails are very common, like onychomycosis or oral thrush [1]. Most people will suffer from those at least once in their lifetime, but these infections are easily diagnosed and respectively curable.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Imaging of Aspergillus fumigatus Pulmonary Infection with Fluorescent, 68Ga-Labelled Siderophores

et al. 2020

View full text Add to dashboard Cite

Aspergillus fumigatus (A. fumigatus) is a human pathogen causing severe invasive fungal infections, lacking sensitive and selective diagnostic tools. A. fumigatus secretes the siderophore desferri-triacetylfusarinine C (TAFC) to acquire iron from the human host. TAFC can be labelled with gallium-68 to perform positron emission tomography (PET/CT) scans. Here, we aimed to chemically modify TAFC with fluorescent dyes to combine PET/CT with optical imaging for hybrid imaging applications. Starting from ferric diacetylfusarinine C ([Fe]DAFC), different fluorescent dyes were conjugated (Cy5, SulfoCy5, SulfoCy7, IRDye 800CW, ATTO700) and labelled with gallium-68 for in vitro and in vivo characterisation. Uptake assays, growth assays and live-cell imaging as well as biodistribution, PET/CT and ex vivo optical imaging in an infection model was performed. Novel fluorophore conjugates were recognized by the fungal TAFC transporter MirB and could be utilized as iron source. Fluorescence microscopy showed partial accumulation into hyphae. µPET/CT scans of an invasive pulmonary aspergillosis (IPA) rat model revealed diverse biodistribution patterns for each fluorophore. [68Ga]Ga-DAFC-Cy5/SufloCy7 and -IRDye 800CW lead to a visualization of the infected region of the lung. Optical imaging of ex vivo lungs corresponded to PET images with high contrast of infection versus non-infected areas. Although fluorophores had a decisive influence on targeting and pharmacokinetics, these siderophores have potential as a hybrid imaging compounds combining PET/CT with optical imaging applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Hybrid Imaging of Aspergillus fumigatus Pulmonary Infection with Fluorescent, 68Ga-Labelled Siderophores

et al. 2020

View full text Add to dashboard Cite

show abstract

“…61,62 A recent review by Kutlubay et al provides an extensive overview of these superficial fungal diseases. 63 Apart from proper foot hygiene (including keeping the feet dry and cool, cleaning gently, and avoiding occlusive footwear 64 ), several over-the-counter and prescription topical antifungal therapies are available to treat mild cases of tinea pedis. 65 Iftheinfectionis severe, chronic, or refractory to topical treatment, oral therapy with fluconazole may be indicated.…”

Section: Tineapedisandmanuummentioning

confidence: 99%

Acral manifestations associated with infection

Jordens

Maeseneer

Crem

et al. 2021

Pediatric Dermatology

View full text Add to dashboard Cite

Acral lesions are well-known physical findings in various infectious disorders.Although they are often overlooked, they can be the key to the diagnosis of the underlyingdisease.Consideringthis,wepresentanoverviewofvariousinfectious causesofacrallesionsinchildhood.Inaddition,wediscusstheircharacteristicpresentation, evolution, and appropriate treatment. To our knowledge, this is the first review covering viral, bacterial and mycotic causes.

show abstract

“…e fungos filamentosos não dermatófitos. Porém, a prevalência de gênero e espécie difere de acordo com a região e o período estudado (CHADEGANIPOUR, MOHAMMADI, 2016;KUTLUBAY et al, 2016).…”

Section: Introductionunclassified

Estudo Da Interferência Biológica Entre Dermatófitos E Leveduras Em Onicomicoses

Lemes¹,

Maschio-Lima²,

Brizzotti³

et al. 2020

Sociedade 5.0:EDUCAÇÃO,CIÊNCIA,TECNOLOGIA E Amor

View full text Add to dashboard Cite

Onicomicoses, também conhecidas popularmente como micoses em unhas, são infecções fúngicas que afetam o leito ungueal e tecidos adjacentes com hiperqueratose, descoloração e onicólise, causadas por fungos dermatófitos, leveduras e fungos filamentosos não dermatófitos. Dentre esses se destacam como agente etiológico desta micose, os fungos filamentosos do gênero Microsporum, Epidermophyton e Trichophyton e a levedura Candida albicans. A interação entre diferentes fungos tem sido objeto de diversos estudos, na qual já foi demonstrado que certas espécies de leveduras podem interferir no crescimento de fungos filamentosos por ação antagônica, com destaque para a produção de substâncias de atividade antifúngica letal. Este estudo tem como objetivo avaliar o potencial antagônico das leveduras Candida albicans, Candida parapsilosis e Candida tropicalis em co-cultivo com os fungos filamentosos Trichophyton rubrum e Trichophyton mentagrophytes, sendo esses isolados clínicos provenientes da micoteca do Laboratório de Microbiologia da Faculdade de Medicina de São José do Rio Preto -FAMERP. Para isso, inóculos de cada cepa foram preparados e diluídos até 1/128 e posteriormente cruzados entre si. Os inóculos foram introduzidos em co-culturas em três diferentes testes, sendo um em meio sólido (Agar Mueller Hinton) e dois em meios líquido (Caldo Sabouraud Dextrose e RPMI). Todos os resultados apontaram inibição no crescimento dos filamentosos perante as leveduras. O antagonismo aqui descrito leva a propor novos procedimentos para a prática clínica, onde o exame micológico direto deve ser considerado e comparado com a cultura.

show abstract

Acral manifestations of fungal infections

Cited by 9 publications

References 85 publications

Hybrid Imaging of Aspergillus fumigatus Pulmonary Infection with Fluorescent, 68Ga-Labelled Siderophores

Hybrid Imaging of Aspergillus fumigatus Pulmonary Infection with Fluorescent, 68Ga-Labelled Siderophores

Acral manifestations associated with infection

Estudo Da Interferência Biológica Entre Dermatófitos E Leveduras Em Onicomicoses

Contact Info

Product

Resources

About