Emerging roles of heterogeneous nuclear ribonucleoprotein K (hnRNP K) in cancer progression

Barboro, Paola; Ferrari, Nicoletta; Balbi, Cecilia

doi:10.1016/j.canlet.2014.06.019

Cited by 91 publications

(90 citation statements)

References 101 publications

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“…26 As a classic example, hnRNP K directly interacts with C-rich regions in the MYC promoter, leading to increased c-Myc expression. 9 In addition, hnRNP K is also thought to translationally regulate c-Myc expression by binding to these same C-rich regions in the 5 0 UTR of the MYC transcript to promote ribosomal loading and further drive c-Myc expression.…”

Section: Biochemical and In Vitro Evidence For A Direct Role Of Hnrnpmentioning

confidence: 99%

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Aberrant hnRNP K expression: All roads lead to cancer

et al. 2016

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The classification of a gene as an oncogene or a tumor suppressor has been a staple of cancer biology for decades. However, as we delve deeper into the biology of these genes, this simple classification has become increasingly difficult for some. In the case of heterogeneous nuclear ribonuclear protein K (hnRNP K), its role as a tumor suppressor has recently been described in acute myeloid leukemia and demonstrated in a haploinsufficient mouse model. In contrast, data from other clinical correlation studies suggest that hnRNP K may be more fittingly described as an oncogene, due to its increased levels in a variety of malignancies. hnRNP K is a multifunctional protein that can regulate both oncogenic and tumor suppressive pathways through a bevy of chromatin-, DNA-, RNA-, and protein-mediated activates, suggesting its aberrant expression may have broad-reaching cellular impacts. In this review, we highlight our current understanding of hnRNP K, with particular emphasis on its apparently dichotomous roles in tumorigenesis.

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Section: Biochemical and In Vitro Evidence For A Direct Role Of Hnrnpmentioning

confidence: 99%

“…24 The roles that hnRNP K plays in these diverse cellular functions are well documented and have been reviewed elsewhere. 25,26 Here; however, we will highlight key points to emphasize its potential role in both oncogenic and tumor suppressive pathways.…”

Section: Introductionmentioning

confidence: 99%

Aberrant hnRNP K expression: All roads lead to cancer

et al. 2016

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“…In agreement with these findings, the protein hnRNPK was significantly down-regulated by 9S-HOD. hnRNPK is a nucleic acid-binding protein that serves as a docking platform integrating transduction pathways to nucleic acid-directed processes [28]. Knock-down of hnRNPK results in strongly reduced migratory activity of cancer cells, strongly suggesting hnRNPK as a promising target molecule for cancer progression [29].…”

Section: Discussionmentioning

confidence: 99%

A proteomic analysis of acute leukemia cells treated with 9-hydroxyoctadecadienoic acid

Chen

Wang

et al. 2016

Lipids Health Dis

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Background9s-hydroxy-octadecadienoic acid (9S-HOD), one of the natural products of linoleic acid oxygenation by 15-lipoxygenase (15-LOX), has been found to have anti-tumor properties in vitro and in vivo. The present study therefore investigated whether 9S-HOD affects acute leukemia HL-60 cells.MethodsThe cytotoxicity of 9S-HOD in HL-60 with or without the presence of fetal bovine serum (FBS) in the culture media was tested using cell viability assays and flow cytometry. To explore the mechanism of its anti-tumor activity by 9S-HOD, we used a proteomic analysis to identify HL-60 cells protein profiles, based on two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) identification.Results9S-HOD exerted cytotoxicity efficacy and induced apoptosis in HL-60 cells, and the cytotoxicity was largely attenuated by the presence of FBS in culture media. The proteomic results revealed that 9S-HOD remarkably altered the abundance of 23 proteins that were involved in mRNA metabolic process, protein binding, DNA replication and apoptosis.ConclusionsOur results indicated that 9S-HOD exerts cytotoxicity in HL-60 cells by affecting several pathways.

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“…Similarly, in an anti-tumor study using Rhizoma paridis, a medicinal herb traditionally consumed for treatment of hepatopathy, the total saponins had been tested and lead to the identification of hepatocarcinoma proteins with altered expression levels (Cheng et al, 2008). Among the twelve differentially-expressed proteins identified in this study, the up-regulated DNase gamma and down-regulated heterogeneous nuclear ribonucleoprotein K (hnRNP K) were particularly to be involved in cancer progression and tumorigenesis (Barboro et al, 2014). Co-incidentally, in a separate study using azactidine and decitabine (two DNA methyltransferase inhibitors used to treat leukemia), the expression of hnRNP was down-regulated by these two aforementioned methyltransferase inhibitors (Buchi et al, 2012).…”

Section: Phytochemical-mediated Cancer Protein Targetsmentioning

confidence: 95%

Phytochemical-mediated Protein Expression Profiling and the Potential Applications in Therapeutic Drug Target Identifications

Wong

Tan

Chai

2015

Critical Reviews in Food Science and Nutrition

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Many phytochemicals derived from edible medicinal plants have been investigated intensively for their various bioactivities. However, the detailed mechanism and their corresponding molecular targets frequently remain elusive. In this review, we present a summary of the research works done on phytochemical-mediated molecular targets, identified via proteomic approach. Concurrently, we also highlighted some pharmaceutical drugs which could be traced back to their origins in phytochemicals. For ease of presentation, these identified protein targets were categorized into two important healthcare-related fields, namely anti-bacterial and anti-cancer research. Through this review, we hope to highlight the usefulness of comparative proteomic as a powerful tool in phytochemical-mediated protein target identifications. Likewise, we wish to inspire further investigations on some of these protein targets identified over the last few years. With contributions from all researchers, the accumulative efforts could eventually lead to the discovery of some target-specific, low-toxicity therapeutic agents.

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Emerging roles of heterogeneous nuclear ribonucleoprotein K (hnRNP K) in cancer progression

Cited by 91 publications

References 101 publications

Aberrant hnRNP K expression: All roads lead to cancer

Aberrant hnRNP K expression: All roads lead to cancer

A proteomic analysis of acute leukemia cells treated with 9-hydroxyoctadecadienoic acid

Phytochemical-mediated Protein Expression Profiling and the Potential Applications in Therapeutic Drug Target Identifications

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