Emerging Roles for Eosinophils in the Tumor Microenvironment

Reichman, Hadar; Karo‐Atar, Danielle; Munitz, Ariel

doi:10.1016/j.trecan.2016.10.002

Cited by 94 publications

(108 citation statements)

References 110 publications

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“…4,6,[26][27][28][29]31 Our analysis adds to this concept. Importantly, the prognostic value of TATE was maintained when TNM stages II and III of the disease were considered.…”

Section: Discussionmentioning

confidence: 94%

“…25 In this context, TATE has been widely studied, as previously revised. 4,6,[26][27][28][29][30][31] In this study, we aimed at reviewing the prognostic value of TATE in CRC. In contrast to previous reviews, which summarized this topic in the context of wider subjects, 4,6,26,28,29,31 our review included a larger number of studies and provided more detailed information on TATE characterization and on the association between TATE and other clinicopathological features in CRC.…”

Section: Discussionmentioning

confidence: 99%

“…Understanding the molecular mechanisms involved in the cross-talk between eosinophils and CRC cells would certainly contribute to improve the existing knowledge of the immunogenic characteristics of the disease and may have a major impact in the development of novel therapeutic targets. 6,9,11,26,28,29,[31][32][33][34][35] In the case of CRC, eosinophil recruitment, activation and survival was suggested to be dependent on local production of IL-5 by tissue resident eosinophils 36 and active damage associated molecular pattern (DAMP) molecules, namely high mobility group box 1 (HMGB1), in the context of tumour cell necrosis. 32 Surprising findings have been achieved on the role of eotaxins in eosinophil chemoatraction to CRCs, since low numbers of tissue eosinophils are found both in primary CRCs 10,37 and liver metastases, 37 albeit not always associated with low levels of tissue eotaxins.…”

Section: Discussionmentioning

confidence: 99%

“…9,15,19 The interaction between eosinophils and other immune cells has been recognized. [26][27][28]31,43 Interestingly, Nagtegaal et al proposed a model for protective immune responses in rectal cancer, in which T cells interact with nonspecific immune response (eosinophils, neutrophils, mast cells, macrophages and NK cells). 15 All these cells have been implicated in CRC prognosis in different extents.…”

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confidence: 99%

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New Insights Into the Role of Tissue Eosinophils in the Progression of Colorectal Cancer: A Literature Review

Saraiva

Carneiro²

2018

Acta Med Port

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RESUMOIntrodução: O papel dos eosinófilos na carcinogénese colorretal tem sido discutido em várias publicações científicas. O objetivo deste estudo foi o de rever o valor dos eosinófilos tecidulares no prognóstico do cancro colorretal, enfatizando a sua identificação, mensuração e associação com as características clinicopatológicas da doença. Material e Métodos:Utilizámos os motores de busca PubMed e Web of Science para pesquisar estudos que associassem os eosinófilos tecidulares com o prognóstico do cancro colorretal.Resultados: Selecionámos 15 estudos para a nossa revisão. Maioritariamente, a análise do infiltrado foi realizada através da coloração de hematoxilina-eosina, com criação de scores. A maioria dos trabalhos descreveu a eosinofilia tecidular como um fator de prognóstico favorável no cancro colorretal e estabeleceu uma associação inversa entre ela e o comportamento metastático dos tumores. A associação com outros fatores de prognóstico foi por vezes abordada, com resultados inconsistentes. A eosinofilia tecidular diminuiu na progressão adenoma-carcinoma. Discussão:Vários mecanismos têm sido propostos para explicar a quimiotaxia de eosinófilos para os tecidos tumorais e a sua interação com as células neoplásicas, sugerindo o envolvimento dos eosinófilos na progressão do cancro colorretal. Apesar de não existir um sistema de avaliação validado, a eosinofilia tecidular associada a tumores pode constituir um parâmetro histopatológico de prognóstico no cancro colorretal. Conclusão:As evidências disponíveis associam a presença de eosinófilos no microambiente do cancro colorretal com a modulação da sua progressão. O impacto clínico deste achado deve ser estudado no futuro. Palavras-chave: Material and Methods:We used PubMed and Web of Science search engines to retrieve studies that looked at the association between tissue eosinophils and colorectal cancer prognosis. Results:We selected 15 studies for our review. In the majority of the studies, eosinophils were identified in hematoxylin-eosin stained sections and scores were generated for analysis. Most of the studies pointed to tumour-associated tissue eosinophilia as a favourable prognostic marker in colorectal cancer and found an inverse association between eosinophil count and the metastatic potential of these neoplasms. The association between tumour-associated tissue eosinophilia and established prognostic markers of colorectal cancer was assessed in some studies, with inconsistent results. Additionally, tumour-associated tissue eosinophilia decreased with the adenoma-carcinoma progression of colorectal lesions.Discussion: Several mechanisms have been proposed regarding eosinophil chemoatraction to tumour tissues and eosinophil-cancer cell cross-talk, suggesting that eosinophils are actively involved in colorectal cancer progression. Although a scoring system is still lacking, tumour-associated tissue eosinophilia meets the criteria of a convenient histopathological prognosticator in colorectal cancer. Conclusion:Collectively, current evidence associa...

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“…4,6,[26][27][28][29]31 Our analysis adds to this concept. Importantly, the prognostic value of TATE was maintained when TNM stages II and III of the disease were considered.…”

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

New Insights Into the Role of Tissue Eosinophils in the Progression of Colorectal Cancer: A Literature Review

Saraiva

Carneiro²

2018

Acta Med Port

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“…Future models could explore other types of cells as potential targets, such as neutrophils and eosinophils, which also harbor the potential to alter the tumor microenvironment in various ways, including modulation of the immune response elicited by cells of the adaptive immune system. 7,8 …”

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confidence: 99%

Harnessing class II histone deacetylases in macrophages to combat breast cancer

Reichman

Munitz

2017

Cell Mol Immunol

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Suppressive Myeloid Cells Shape the Tumor Immune Microenvironment

Xiong

Wang

2021

Advanced Biology

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Cancer is the outcome of the conflict between the host immune system and cancer cells. The crosstalk between immune cells and tumor cells within the tumor microenvironment (TME) influences tumor progression and metastasis. Many studies have clarified the cellular and molecular events that can induce cancer cells to escape immune surveillance, including those involving tumor‐induced myeloid cell‐mediated immunosuppression. Emerging evidence indicates that tumor‐infiltrating myeloid cells (TIMs) accelerate tumor growth and induce angiogenesis, metastasis, and therapy resistance once converted into potent immunosuppressive cells. Here, how tumor infiltrating myeloid cells participate in tumor immune evasion and the prospects of these cells in cancer immunotherapy are discussed.

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Emerging Roles for Eosinophils in the Tumor Microenvironment

Cited by 94 publications

References 110 publications

New Insights Into the Role of Tissue Eosinophils in the Progression of Colorectal Cancer: A Literature Review

New Insights Into the Role of Tissue Eosinophils in the Progression of Colorectal Cancer: A Literature Review

Harnessing class II histone deacetylases in macrophages to combat breast cancer

Suppressive Myeloid Cells Shape the Tumor Immune Microenvironment

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