Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: A review of their intracellular targets

Modulation of some markers of erectile dysfunction and malonaldehyde levels in isolated rat penile tissue with unripe and ripe plantain peels: identification of the constituents of the plants using HPLC

“…The inhibition of AChE by the extracts substantiate the folkloric use of plantain peels in the management and/or treatment of ED. The inhibition of AChE by the peels correlates with recent studies that plant derived AChE inhibitors can be employed in ameliorating ED, and can also prevent oxidative stress in neuronal cells of penile tissue (Ramassamy 2006;Hostettmann et al 2006;Butterfield and Lauderback 2002;Andersson 2011;Nunes and Webb 2012;Akomolafe et al 2016). The inhibition of AChE by the extracts could be associated with the presence of phenolic compounds.…”

Dietary Blueberry Supplementation Affects Growth but Not Vascularization of Neural Transplants

“…Recent animal studies of dietary supplements have corroborated these observations and have shown that nutritional compounds can have profound effects on physiologic processes such as cardiovascular health (Stoclet et al, 2004), cancer prevention (Dulak, 2005), and neurologic performance (Stoclet et al, 2004;Ramassamy, 2006).…”

Small molecule inhibitors of Aβ‐aggregation and neurotoxicity

“…Epidemiological studies indicating a significantly lower prevalence of AD in the Asian Indian population compared to the United States suggest the possibility of a dietary correlation [Ganguli et al, 2000;Ramassamy, 2006]. The common use of tumeric as a curry spice has pointed to its main constituent, curcumin, as a possible mediator of anti-Ab effects.…”

“…Polyphenols are a large group of synthetic and naturally occurring small molecules that are composed of one or more aromatic phenolic rings and are divided into three main groups, including phenolic acids, flavonoids, and non-flavonoid polyphenols [Ramassamy, 2006]. Experimental and epidemiological evidence suggests that natural polyphenolic compounds, such as those found in teas, berries, fruits, spices, and plants, have antioxidative, anti-inflammatory, and anti-aggregant properties.…”

“…The standardized concentrated extract, EGb-761, contains a mixture of 27% flavonols (e.g., quercetin, kaempferol, and isorhamnetin) and 6-7% terpene lactones (e.g., bilobalide and gingkolides A, B, and C) [Augustin et al, 2008;Ramassamy, 2006;Vitolo et al, 2007]. Both EGb-761 and its constituents have been investigated for their neuroprotective properties against Ab-induced toxicity.…”