Emerging role of circular RNAs in the pathobiology of lung cancer

Ghafouri‐Fard, Soudeh; Dinger, Marcel E.; Maleki, Parichehr; Taheri, Mohammad; Hajiesmaeili, Mohammadreza

doi:10.1016/j.biopha.2021.111805

Cited by 9 publications

(4 citation statements)

References 44 publications

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“…Another circRNA down-regulated in NSCLC that may prevent lymphatic metastasis is hsa_circ_0033155. Inhibition of tumor growth, colony formation, and migration occur after ectopic expression of hsa_circ_0033155 [ 119 ].…”

Section: Implication Of Exosomal Circrna In Lung Cancer Progressionmentioning

confidence: 99%

Exosomal circular RNA: a signature for lung cancer progression

et al. 2022

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Membrane vesicles having a diameter of 30–150 nm are known as exosomes. Several cancer types secrete exosomes, which may contain proteins, circular RNAs (circRNAs), microRNAs, or DNA. CircRNAs are endogenous RNAs that do not code for proteins and can create continuous and covalently closed loops. In cancer pathogenesis, especially metastasis, exosomal circRNAs (exo-circRNAs) have a crucial role mainly due to the frequently aberrant expression levels within tumors. However, neither the activities nor the regulatory mechanisms of exo-circRNAs in advancing lung cancer (LC) are obvious. A better understanding of the regulation and network connections of exo-circRNAs will lead to better treatment for LCs. The main objective of the current review is to highlight the functions and mechanisms of exo-circRNAs in LC and assess the relationships between exo-circRNA dysregulation and LC progression. In addition, underline the possible therapeutic targets based on exo-circRNA modulating.

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Section: Implication Of Exosomal Circrna In Lung Cancer Progressionmentioning

confidence: 99%

Exosomal circular RNA: a signature for lung cancer progression

et al. 2022

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“…Different types of lung cancer have different molecular mechanisms, therapeutic targets and prognoses. Contemporary emerging evidence has indicated that circRNAs are abnormally expressed and have pivotal roles in different lung cancers ( 51 ). However, the expression patterns and clinical significance of different circRNAs in different types of lung cancer remain to be fully elucidated.…”

Section: Characteristic Circrnas In the Progression Of Different Type...mentioning

confidence: 99%

Landscape of circular RNAs in different types of lung cancer and an emerging role in therapeutic resistance (Review)

Wang

Chen

et al. 2022

Int J Oncol

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Lung cancer is one of the most common malignant tumor types and the leading cause of cancer-associated death worldwide. Different types of lung cancer exhibit differences in terms of pathophysiology and pathogenesis, and also treatment and prognosis. Accumulating evidence has indicated that circular RNAs (circRNAs) are abnormally expressed among different types of lung cancer and confer important biological functions in progression and prognosis. However, studies comparing different circRNAs in lung cancer subtypes are scarce. Furthermore, circRNAs have an important role in drug resistance and are related to clinicopathological features in lung cancer. Summaries of the association of circRNAs with drug resistance are also scarce in the literature. The present study outlined the biological functions of circRNAs and focused on discriminating differential circRNA patterns and mechanisms in three different types of lung cancer. The emerging roles of circRNAs in the resistance to chemotherapy, targeted therapy, radiotherapy and immunotherapy were also highlighted. Understanding these aspects of circRNAs sheds light on novel physiological and pathophysiological processes of lung cancer and suggests the application of circRNAs as biomarkers for diagnosis and prognosis, as well as therapeutic resistance.

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“…Its function, mechanism, and potential diagnostic and therapeutic targets have attracted substantial attention 7 . Unlike linear RNA, the circular structure of circRNA is stable; therefore, it is not easily degraded by nucleases 8 . CircRNA was first discovered in plant viruses in 1976 and did not receive much attention initially 9 .…”

Section: Introductionmentioning

confidence: 99%

The diagnostic value of has_circ_0006423 in non-small cell lung cancer and its role as a tumor suppressor gene that sponges miR-492

Zhu

et al. 2022

Sci Rep

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The diagnosis and treatment of non-small cell lung cancer (NSCLC) are not ideal. We identified NSCLC-related has_circ_0006423 in database. qRT-PCR was used to measure expression levels of hsa_circ_0006423 and miR-492 in the plasma and tissue samples, and 3 NSCLC cell lines, respectively. We analyzed the relationship between expression levels of hsa_circ_0006423 and clinicopathological factors and miR-492 expression in plasma and tissue samples. Assess the diagnostic value of hsa_circ_0006423 and miR-492 in NSCLC. Cell function vitro experiment to explore the effect of has_circ_0006423 on NSCLC. We found has_circ_0006423 is lower expressed in NSCLC and miR-492 is opposite, has_circ_0006423 and miR-492 has diagnostic value in NSCLC. In A549 and NCI-H1299 cells, hsa_circ_0006423 inhibited the proliferation, migration, and invasion of NSCLC cells by sponging miR-492 and accelerating NSCLC cell apoptosis. This effect may be due to the combination of has_circ_0006423 and miR-492 affecting the progression of NSCLC.

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Emerging role of circular RNAs in the pathobiology of lung cancer

Cited by 9 publications

References 44 publications

Exosomal circular RNA: a signature for lung cancer progression

Exosomal circular RNA: a signature for lung cancer progression

Landscape of circular RNAs in different types of lung cancer and an emerging role in therapeutic resistance (Review)

The diagnostic value of has_circ_0006423 in non-small cell lung cancer and its role as a tumor suppressor gene that sponges miR-492

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