Emerging point-of-care technologies for anemia detection

An, Ran; Huang, Yu‐Ning; Man, Yuncheng; Valentine, R. W.; Kucukal, Erdem; Goreke, Utku; Sekyonda, Zoe; Piccone, Connie M.; Owusu-Ansah, Amma; Ahuja, Sanjay P.; Little, Jane A.; Gürkan, Umut A.

doi:10.1039/d0lc01235a

Cited by 30 publications

(20 citation statements)

References 181 publications

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“…In SCD, sickle RBCs are vulnerable to shear flow stress and hemolysis, which triggers release of microvesicles and cell-free hemoglobin. [79][80][81] We postulate that hemolysis leads to a decreased surface-to-volume ratio and disrupted cytoskeletal network in RBCs in SCD, which translates to observed enhanced microcapillary occlusion. In addition, in sickle RBCs, BCAM/Lu binds to the LN alpha 5 chain.…”

Section: Discussionmentioning

confidence: 99%

Microfluidic concurrent assessment of red blood cell adhesion and microcapillary occlusion: potential hemorheological biomarkers in sickle cell disease

Man

et al. 2023

Sens. Diagn.

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Section: Discussionmentioning

confidence: 99%

Microfluidic concurrent assessment of red blood cell adhesion and microcapillary occlusion: potential hemorheological biomarkers in sickle cell disease

Man

et al. 2023

Sens. Diagn.

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“…An approach that may offer a compromise to advocates of PBM and those of limited testing is to use of point-of-care hemoglobin screening with formal laboratory testing only in those who screen as anemic [38]. There are a number of minimally invasive and non-invasive devices that could perform this in a cost-effective fashion [39]. Future research could look at the impact of a more broad perioperative anemia screening program in all surgical patients.…”

Section: Discussionmentioning

confidence: 99%

Estimating the prevalence of anemia and its association with perioperative blood transfusion in patients who have no haemoglobin measurement using multiple imputation and inverse probability of treatment weighting

Miller¹,

Delroy-Buelles²,

Congreve³

et al. 2022

Preprint

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Anemic patients are at increased risk of intraoperative and postoperative transfusion, infection and mortality. Anemia is common in surgical patients, previous studies report a prevalence of 30-40%. While patient blood management programs advise screening for anemia, other perioperative initiatives advocate limiting preoperative laboratory testing. Therefore, a large number of surgical patients may not be screened, missing the opportunity for further investigation and management. In our single-center retrospective cohort study of all adult surgical patients over one year, we sought to estimate the proportion of anemia in patients without a preoperative blood test and their associated intraoperative and postoperative transfusion risk using multiple imputation to estimate missing hemoglobin values and inverse-probability-of-treatment-weighting to balance the study groups. Multiple imputation generated 39 datasets containing plausible hemoglobin values for patients missing a hemoglobin. Patients were classified as known-anemic, known-not-anemic, imputed-anemic and imputed-not-anemic if the hemoglobin was measured or imputed. We then compared red-cell transfusion yes/no by logistic regression, and number of red-cell units transfused by linear regression, pooling the results. Thirty-nine percent of 7879 patients were missing a hemoglobin, of whom 20-35% may be anemic. Only known-anemic patients had an increased intraoperative transfusion risk (odds ratio (OR) 3.13, 95% confidence interval (95%CI) 2.19 to 4.48). Both known-anemic and imputed-anemic patients had increased postoperative transfusion risk (OR 3.93 (95%CI 2.92 to 5.29), OR 2.99 (95%CI 1.61 to 5.56), respectively). Anemia may be common in patients missing a haemoglobin, and may confer an increased risk of postoperative transfusion compared to known-anemic patients. Removing them from observation studies on anemia risks sample bias. Excluding patients from pre-operative testing may miss the opportunity to identify anemia and modify postoperative transfusion risk and other adverse health outcomes. Future research could use point-of-care tests to reduce screening costs, and further investigate adverse outcomes risks in these missing patients.

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“…Nearly 7% of the people in the world carry hemoglobin gene variants. Most prevalent hemoglobin variants are the recessive β-globin gene mutations, βS or S, βC or C, and βE or E 2,3 .Genetic disorders, such as SCD, are among the major causes for anemia [4][5][6][7] .…”

Section: Sickle Cell Diseasementioning

confidence: 99%

A retrospective case study of successful translational research: Gazelle Hb variant point-of-care diagnostic device for sickle cell disease

Qua

Swiatkowski

Gürkan

et al. 2021

J. Clin. Trans. Sci.

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Emerging point-of-care technologies for anemia detection

Abstract: Anemia, characterized by low blood hemoglobin level, affects about 25% of the world's population with the heaviest burden borne by women and children. Anemia leads to impaired cognitive development in...

Cited by 30 publications

References 181 publications

Microfluidic concurrent assessment of red blood cell adhesion and microcapillary occlusion: potential hemorheological biomarkers in sickle cell disease

Microfluidic concurrent assessment of red blood cell adhesion and microcapillary occlusion: potential hemorheological biomarkers in sickle cell disease

Estimating the prevalence of anemia and its association with perioperative blood transfusion in patients who have no haemoglobin measurement using multiple imputation and inverse probability of treatment weighting

A retrospective case study of successful translational research: Gazelle Hb variant point-of-care diagnostic device for sickle cell disease

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