Emerging pathogens caused disease and mortality in freshwater mussels,<i>Hyriopsis cumingii,</i>in China

Yang, Qinglin; Li, Wenyu; Du, Chunying; Liu, Yang; Shang, Ma; Yu, Xiaobo; Yao, Weizhi; Wu, Zhengli

doi:10.1111/are.14848

Cited by 9 publications

(5 citation statements)

References 35 publications

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“…Ammonia exposure also caused large interlamellar space, the exfoliation of cilia, and pyknosis of nucleus in the gills of H. cumingii. These have been observed in H. cumingii after bacterial challenge [57] and exposed to Microcystis aeruginosa under hypoxia [58]. The observed histological changes in our test indicated that ammonia caused severe damage to the internal physiology of the hepatopancreas and gills.…”

Section: Discussionsupporting

confidence: 68%

Effects of Acute Ammonia Stress on Antioxidant Responses, Histopathology and Ammonia Detoxification Metabolism in Triangle Sail Mussels (Hyriopsis cumingii)

Zhao

Feng

Zhang

et al. 2021

Water

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Ammonia is one of the major pollutants in the aquatic ecosystem. Hyriopsis cumingii has great potential for the restoration of eutrophic water. However, there is no study investigating the effect of ammonia exposure in H. cumingii. The median lethal concentration (96 h LC50) of unionized ammonium was 12.86 mg/L in H. cumingii. In the study, H. cumingii were exposed to 6.43 mg L−1 unionized ammonium (1/2 96 h LC50) for 0, 6, 12, 24, 48, 72, and 96 h. High environment ammonia induced antioxidant response to protect the body from oxidative damage. After exposure to ammonia, there was a same trend of induction followed by inhibition of the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione-S-transferases (GST) in the hepatopancreas and gills of H. cumingii. However, the antioxidant response could not completely counteract the oxidation effect during the exposure period, resulting in lipid peroxidation (LPO) and tissue injury in the hepatopancreas and gills of H. cumingii eventually. Moreover, this study indicated that glutamine synthetase (GS), glutamate dehydrogenase (GDH), alanine aminotransaminase (ALT), and aspartate aminotransaminase (AST) in the hepatopancreas and gills may play an important role in ammonia detoxification of H. cumingii. Our results will be helpful to understand the mechanism of aquatic toxicology induced by ammonia in shellfish.

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Section: Discussionsupporting

confidence: 68%

Effects of Acute Ammonia Stress on Antioxidant Responses, Histopathology and Ammonia Detoxification Metabolism in Triangle Sail Mussels (Hyriopsis cumingii)

Zhao

Feng

Zhang

et al. 2021

Water

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“…Moreover, K. oxytoca can acquire antimicrobial resistance and carry multiple virulence genes, such as capsular polysaccharides and fimbriae [48]. The virulence of other species analyzed in this study, such as H. alvei [49], M. morganii [50], P. vulgaris [51], S. maltophilia [52], and R. planticola [53], has been previously reported.…”

Section: Virulence Factorsmentioning

confidence: 70%

“…Virulence Factor of Pathogenic Bacteria Database (VFDB) (http://www.mgc.ac.cn/ VFs/, accessed on 13 December 2022) was used to characterize virulence factors. Additionally, we prolonged the analysis to include virulence factors that are contained in several scientific publications [47][48][49][50][51][52][53].…”

Section: Virulence Factorsmentioning

confidence: 99%

Shotgun Proteomics Analysis, Functional Networks, and Peptide Biomarkers for Seafood-Originating Biogenic-Amine-Producing Bacteria

Abril

Calo-Mata

Böhme

et al. 2023

IJMS

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Biogenic amine-producing bacteria are responsible for the production of basic nitrogenous compounds (histamine, cadaverine, tyramine, and putrescine) following the spoilage of food due to microorganisms. In this study, we adopted a shotgun proteomics strategy to characterize 15 foodborne strains of biogenic-amine-producing bacteria. A total of 10,673 peptide spectrum matches belonging to 4081 peptides and corresponding to 1811 proteins were identified. Relevant functional pathways were determined, and strains were differentiated into hierarchical clusters. An expected protein-protein interaction network was created (260 nodes/1973 interactions). Most of the determined proteins were associated with networks/pathways of energy, putrescine metabolism, and host-virus interaction. Additionally, 556 peptides were identified as virulence factors. Moreover, 77 species-specific peptide biomarkers corresponding to 64 different proteins were proposed to identify 10 bacterial species. This represents a major proteomic dataset of biogenic-amine-producing strains. These results may also be suitable for new treatments for food intoxication and for tracking microbial sources in foodstuffs.

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“…213 Stenotrophomonas maltophilia and A. veronii were isolated from cultured H. cumingii from a large mortality event, and subsequent experimental infections resulted in myofiber degeneration and gill necrosis in infected mussels; intralesional bacteria were not reported. 214 Another study to investigate the immune response to bacterial infection at the transcriptomic level showed 5957 differentially expressed genes in H. cumingii challenged with A. veronii. 213 The study of bacteria in freshwater mussels is complicated by the fact that freshwater mussels constantly interact with bacteria in the aquatic ecosystem, use bacteria as a food source, 198 and host diverse bacterial taxa in health.…”

Section: Bacteriamentioning

confidence: 99%

Section: Bacteriamentioning

confidence: 99%

Pathology and infectious agents of unionid mussels: A primer for pathologists in disease surveillance and investigation of mortality events

et al. 2023

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Freshwater mussels are one of the most imperiled groups of organisms in the world, and more than 30 species have gone extinct in the last century. While habitat alteration and destruction have contributed to the declines, the role of disease in mortality events is unclear. In an effort to involve veterinary pathologists in disease surveillance and the investigation of freshwater mussel mortality events, we provide information on the conservation status of unionids, sample collection and processing techniques, and unique and confounding anatomical and physiological differences. We review the published accounts of pathology and infectious agents described in freshwater mussels including neoplasms, viruses, bacteria, fungi, fungal-like agents, ciliated protists, Aspidogastrea, Digenea, Nematoda, Acari, Diptera, and Odonata. Of the identified infectious agents, a single viral disease, Hyriopsis cumingii plague disease, that occurs only in cultured mussels is known to cause high mortality. Parasites including ciliates, trematodes, nematodes, mites, and insects may decrease host fitness, but are not known to cause mortality. Many of the published reports identify infectious agents at the light or ultrastructural microscopy level with no lesion or molecular characterization. Although metagenomic analyses provide sequence information for infectious agents, studies often fail to link the agents to tissue changes at the light or ultrastructural level or confirm their role in disease. Pathologists can bridge this gap between identification of infectious agents and confirmation of disease, participate in disease surveillance to ensure successful propagation programs necessary to restore decimated populations, and investigate mussel mortality events to document pathology and identify causality.

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Emerging pathogens caused disease and mortality in freshwater mussels,Hyriopsis cumingii,in China

Cited by 9 publications

References 35 publications

Effects of Acute Ammonia Stress on Antioxidant Responses, Histopathology and Ammonia Detoxification Metabolism in Triangle Sail Mussels (Hyriopsis cumingii)

Effects of Acute Ammonia Stress on Antioxidant Responses, Histopathology and Ammonia Detoxification Metabolism in Triangle Sail Mussels (Hyriopsis cumingii)

Shotgun Proteomics Analysis, Functional Networks, and Peptide Biomarkers for Seafood-Originating Biogenic-Amine-Producing Bacteria

Pathology and infectious agents of unionid mussels: A primer for pathologists in disease surveillance and investigation of mortality events

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