2019
DOI: 10.1016/j.jgar.2018.10.015
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Emerging metronidazole resistance in Bacteroides spp. and its association with the nim gene: a study from North India

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Cited by 24 publications
(23 citation statements)
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“…Phenotypic results revealed that 41% of B. fragilis were resistant to metronidazole, the commonest drug used for treating anaerobic infections [22]. This is comparable with an Indian study by Sethi et al [23] which reported 41% resistance, and [29]. Interestingly, in a study from , 14% of susceptible isolates were reported to carry the nim gene.…”
Section: Discussionsupporting
confidence: 73%
“…Phenotypic results revealed that 41% of B. fragilis were resistant to metronidazole, the commonest drug used for treating anaerobic infections [22]. This is comparable with an Indian study by Sethi et al [23] which reported 41% resistance, and [29]. Interestingly, in a study from , 14% of susceptible isolates were reported to carry the nim gene.…”
Section: Discussionsupporting
confidence: 73%
“… 20 , 21 In recent reports from India, the nim gene was detected at a notably high prevalence in BFG isolated from clinical samples. 29 , 30 This study is the first surveillance on the presence of nim -carrying anaerobes among isolates from healthy individuals in Vietnam. In Vietnam, metronidazole is widely used to treat anaerobic and parasitic infections; however, metronidazole resistance or circulation of the nim gene has not yet been investigated in Vietnam.…”
Section: Discussionmentioning
confidence: 96%
“…Gal et al [ 54 ] found that only about half of the 50 Bacteroides strains positive for the nim gene presented minimum inhibitory concentrations (MICs) ranging from 16 to >32 µg/mL—therefore, above the resistance breakpoint. Sethi et al [ 59 ] looked at the MTZ resistance rates in India and the relationship of isolates positive for a nim gene with resistance. They found a relatively high rate of resistance (31% compared to <1% in Europe), with a 53% rate of positivity for the nim gene.…”
Section: Metronidazolementioning
confidence: 99%
“…They found a relatively high rate of resistance (31% compared to <1% in Europe), with a 53% rate of positivity for the nim gene. Out of 20 samples, 12 that were positive for the nim gene also showed resistance to MTZ, a significant correlation [ 59 ]. Leitsch et al [ 60 ] ascertained the levels of expression of the nim genes using 2D gel electrophoresis (2DE).…”
Section: Metronidazolementioning
confidence: 99%