Emerging materials for the electrochemical detection of COVID-19

Balkourani, Georgia; Brouzgou, A.; Archonti, M.; Παπανδριανός, Νικόλαος; Song, Shuqin; Tsiakaras, Panagiotis

doi:10.1016/j.jelechem.2021.115289

Cited by 47 publications

(20 citation statements)

References 113 publications

(135 reference statements)

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“…Electrochemical biosensors are known for their small size, cost-effectiveness, ease of use and fast response. These types of sensors are extensively used in the development of point of care devices for diagnosing viral infections [ 68 , 69 ]. Among the electrochemical techniques, screen-printed electrode (SPE) technology has aided the development of portable sensors considerably as it provides miniaturised but robust and user-friendly electrodes at low production costs [ 70 , 71 ].…”

Section: Latest Developed Biosensors For Covid-19mentioning

confidence: 99%

Emerging Biosensors to Detect Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Review

2021

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Coronavirus disease (COVID-19) is a global health crisis caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) is the gold standard test for diagnosing COVID-19. Although it is highly accurate, this lab test requires highly-trained personnel and the turn-around time is long. Rapid and inexpensive immuno-diagnostic tests (antigen or antibody test) are available, but these point of care (POC) tests are not as accurate as the RT-PCR test. Biosensors are promising alternatives to these rapid POC tests. Here we review three types of recently developed biosensors for SARS-CoV-2 detection: surface plasmon resonance (SPR)-based, electrochemical and field-effect transistor (FET)-based biosensors. We explain the sensing principles and discuss the advantages and limitations of these sensors. The accuracies of these sensors need to be improved before they could be translated into POC devices for commercial use. We suggest potential biorecognition elements with highly selective target-analyte binding that could be explored to increase the true negative detection rate. To increase the true positive detection rate, we suggest two-dimensional materials and nanomaterials that could be used to modify the sensor surface to increase the sensitivity of the sensor.

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Section: Latest Developed Biosensors For Covid-19mentioning

confidence: 99%

Emerging Biosensors to Detect Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Review

2021

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“…Because nanostructures are of similar size to that of SARS-CoV-2, nanostructures can bind to the virus and thus can be utilized for therapy and detection of COVID-19 infection [28] . The use of nanotechnology and nanostructures in order to develop diagnostic and serological tests for COVID-19 infection is increasing greatly [29] – [32] . Nanomaterials can be functionalized with biomolecules to detect and amplify signal in colorimetric detection of pathogens [33] , and large surface area of nanostructures increases capture efficiency of, and thus sensitivity of a biosensor [34] .…”

Section: Role Of Nanotechnology In the Detection Of Sars-cov-2mentioning

confidence: 99%

“…In the place of commonly used gold nanostructures in biosensor to detect SARS-CoV-2, some research groups used carbon nanotubes [41] , [48] , graphene [49] , [50] , and graphene-based (graphene oxide or reduced graphene oxide) [51] nanomaterials due to carbon nanotube's and graphene's high conductivity and biocompatibility [52] , [53] , and benefit of lower cost [29] . Further, the modification of graphene's surface with functional groups imparts the biosensor with very high sensitivity and ability to recognize biological molecule [54] .…”

Section: Role Of Nanotechnology In the Detection Of Sars-cov-2mentioning

confidence: 99%

Nanotechnology-based approaches in the fight against SARS-CoV-2

Albaz¹,

Rafeeq²,

Sain³

et al. 2021

AIMSMICRO

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<abstract> <p>The COVID-19 pandemic caused by highly-infectious virus namely severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in infection of millions of individuals and deaths across the world. The need of an hour is to find the innovative solution for diagnosis, prevention, and cure of the COVID-19 disease. Nanotechnology is emerging as one of the important tool for the same. In the present review we discuss the applications of nanotechnology-based approaches that are being implemented to speed up the development of diagnostic kits for SARS-CoV-2, development of personal protective equipments, and development of therapeutics of COVID-19 especially the vaccine development.</p> </abstract>

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“…Such nano-biosensors have wide application potential with various detection formats ( Lima et al, 2021 ). Immuno-based biosensing devices as a fast and real-time platform approach would help to monitor the pandemic ( Balkourani et al, 2021 ; Lu et al, 2021 ; Mahshid et al, 2021 ; Weissleder et al, 2020b ). Rashed et al (2021) demonstrated electrochemical impedance based on commercially available sensing electrodes precoated with receptor-binding domain (RBD) and tested with samples of anti-SARS-CoV-2 monoclonal antibody CR3022.…”

Section: Introductionmentioning

confidence: 99%