Emerging inorganic nanomaterials for pancreatic cancer diagnosis and treatment

Yang, Feng; Jin, Chen; Subedi, Sabin; Lee, Chong Lek; Wang, Qiang; Jiang, Yongjian; Li, Ji; Yang, Di; Fu, Deliang

doi:10.1016/j.ctrv.2012.02.003

Cited by 114 publications

(73 citation statements)

References 173 publications

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“…Por outro lado, seu grupo R é capaz de reagir com os monômeros a serem polimerizados formando assim materiais híbridos orgânicos inorgânicos [13]. Os agentes silanos mais utilizados são: 3-aminopropiltrimetoxissilano, 3-aminopropiltrietoxissilano, tetraetilortossilicato, meta-criloxipropiltrimethoxissilano, 3-cloropropil-trimetoxissilano e trietoxivinilsilano [14][15][16][17].…”

Section: +unclassified

Modificação da superfície de nanocompósitos de Fe2O3/Fe3O4 visando seu uso para imobilização da glicose oxidase

et al. 2017

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INTRODUÇÃOAs nanopartículas magnéticas (NPMs) Químico, Sabará, MG, patytaraujo@gmail.com, daniel.r.cornejo@gmail.com, dbrandao@jhs.med.br, libiaconrado@yahoo.com.br, ana.costa@ufcg.edu.br Resumo O aumento no número de pessoas portadoras de diabetes nos últimos anos e a elevada relação custo benefício da tecnologia de biossensores existentes têm motivado um crescente interesse no desenvolvimento de biossensores de detecção de glicose baseados na imobilização da glicose oxidase (GOD) utilizando-se principalmente nanopartículas magnéticas. Neste contexto, nanocompósitos de Fe 2 O 3 /Fe 3 O 4 foram sintetizados por reação de combustão e tiveram sua superfície modificada com 3-aminopropiltrimetoxissilano via reação de silanização e com quitosana via reação de funcionalização para obter um material híbrido que foi avaliado como possível imobilizador de GOD. As amostras foram caracterizadas por difração de raios X, espectroscopia de infravermelho com transformada de Fourier, análise termogravimétrica, microscopia eletrônica de varredura e de transmissão, propriedades magnéticas e citotoxidade in vitro. Os resultados mostraram que foi possível obter o compósito ferrimagnético, a modificação da superfície reduziu a magnetização de saturação, mas manteve a característica ferrimagnetica, e todas as amostras foram consideradas não tóxicas. Para os testes preliminares de imobilização da GOD foi revelado que o nanocompósito modificado com silano e quitosana apresentou melhor resultado, cerca de 2,7 mg de GOD imobilizados para cada 100 mg de nanocompósito, o que torna este material uma possível alternativa para ser utilizado na fabricação de bissensores de GOD. Palavras-chave: nanocompósitos, modificação da superfície, imobilização de GOD. Abstract The increase in the number of people with diabetes in recent years and the high cost-benefit ratio of the existing biosensor technology have increased the interest for the development of glucose detection biosensor based on immobilization of glucose-oxidase (GOD

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Section: +unclassified

Modificação da superfície de nanocompósitos de Fe2O3/Fe3O4 visando seu uso para imobilização da glicose oxidase

et al. 2017

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“…Anticancer activity of chemotherapeutics is not selective to tumours often causing damage to healthy tissues [4,[6][7][8]. Unfavourable drug pharmacokinetics (low half-life time in the bloodstream) and pharmacodynamics (unselective drug-receptor interactions) combined with high drug doses and poor drug solubility are the principal limitations of conventional chemotherapy [7,[9][10][11][12]. In cancer treatment, there are challenges in design and optimization of a synergism among different therapeutic components and a myriad of drugs to conquer the above mentioned limitations.…”

Section: Class Of Chemotherapeutic Agents Examplesmentioning

confidence: 99%

“…DDS have impact in therapeutics and diagnostics applications due to their unique electrical, chemical and optical characteristics, biocompatibility and reactive surface, which confer high potential to improved drug bioavailability, drug controlled release, favourable pharmacologic and pharmacodynamic properties and significant reduction of unwanted systemic side effects [6,8,11,35].…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

“…It was demonstrated by Zhang that glutathione-loaded AuNPs are metabolized by renal clearance while Bovine Serum Albumin-loaded AuNPs show damages in liver, kidney and mice infection [178]. AuNPs are used for many biomedical applications including drug delivery vectors based on covalent reaction, drug encapsulation, electrostatic adsorption and non-covalent conjugation [11,105,[179][180][181][182]. AuNPs can improve anticancer effects of many drugs by increasing drug delivery to cancer cells [183], which can be facilitated by passive or active targeting mechanisms [184].…”

Section: Metal-based Nanoparticlesmentioning

confidence: 99%

“…For comparison the animal group treated only with X-rays had only 20% oneyear survival. When combined with chemotherapeutic agents AuNPs offer a promising therapeutic strategy for advanced stage cancer patients [11,117]. The first clinical trial with the AuNP and rhTNF nanoconstruct (Aurimune, CYT-6091) showed no dose-limiting toxicity of rhTNF [117].…”

Section: B Amentioning

confidence: 99%

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Supramolecular nanoscale assemblies for cancer diagnosis and therapy

Coelho

Pereira

Juzeniene

et al. 2015

Journal of Controlled Release

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Nanocarriers based on polymers, metals and lipids have been extensively developed for cancer therapy and diagnosis due to their ability to enhance drug accumulation in cancer cells and decrease undesired drug toxicity in healthy tissues. Overcoming multidrug resistance by designing proper drug nanocarriers will improve outcome of existing oncologic treatments such as chemotherapy or radiotherapy. In this article the relation between physicochemical properties and capacity of a nanosystem to deliver therapeutic agents into pathological sites is discussed. Most promising examples of drug delivery systems are reviewed, and, in particular, the design of a carbohydrate based matrix with entrapped gold nanoparticles is highlighted.

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