Emerging incidence trends of eosinophilic esophagitis over 25 years: Results of a nationwide register‐based pathology cohort

Abstract

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Poor Adherence to Medical and Dietary Treatments in Adult Patients With Eosinophilic Esophagitis

“…Our center is an EoE expert center with nationwide referrals; it is therefore possible that the patients included have a more-than-average disease severity. On the other hand, age and sex of the patients are very similar to the overall EoE population in our country (30).…”

“…The strongest significant predictors for poor treatment adherence were young age and low necessity beliefs, which have also been identified before in other chronic diseases (15,17). Considering the high proportion of young patients in EoE, this is an important observation (30). Other factors, such as education and dilation ever (as an expression of a more severe disease phenotype), had strength but were not significant.…”

“…Our center is an EoE expert center with nationwide referrals; it is therefore possible that the patients included have a more-than-average disease severity. On the other hand, age and sex of the patients are very similar to the overall EoE population in our country (30). Future research should focus on whether treatment adherence changes over time and what the optimal timing and strategy for intervention is (13,34).…”

Incidence and prevalence of eosinophilic oesophagitis: Are we reaching a plateau?

“…The latter can be investigated by dividing the number of cases by the number of gastroduodenoscopies with biopsies performed in the region during the same time period. Previously we have learned that for instance the initial rise in incidence of Barrett's oesophagus is not due to an increase in gastroduodenoscopies 5 and for EoE it has been suggested by others that the increase in EoE incidence outpaces the rate of increase of biopsy rates, 6 although data from these studies date back to early and mid‐2000s. 7 In the current study, the authors note that the number of biopsies increased during the study period but the occurrence of EoE in biopsies remained stable, implying that the more widespread use of gastroduodenoscopies with biopsies may at least partially explain the increase.…”

“…The latter can be investigated by dividing the number of cases by the number of gastroduodenoscopies with biopsies performed in the region during the same time period. Previously we have learned that for instance the initial rise in incidence of Barrett's oesophagus is not due to an increase in gastroduodenoscopies 5 and for EoE it has been suggested by others that the increase in EoE incidence outpaces the rate of increase of biopsy rates, 6 although data from these studies date back to early and mid‐2000s 7 …”