Emerging epigenetic insights into aging mechanisms and interventions

Wu, Zeming; Zhang, Weiqi; Qu, Jing; Liu, Guang-Hui

doi:10.1016/j.tips.2023.12.002

Cited by 7 publications

(3 citation statements)

References 160 publications

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“…Different types of stress can induce cell senescence, such as chemicals [127], therapeutic agents [128][129][130], UV radiation [131][132][133], pollution [134], or epigenetics factors, etc. [135]. Stress related inflammation and immunosuppression lead to tissue damage and accumulation of the senescent cells in the skin promoting skin aging [81,[136][137][138][139][140][141].…”

Section: Skin and Photo-aging 21 The Damaging Effects Of Uv Radiation...mentioning

confidence: 99%

Promising Functions of Novel Vitamin D Derivatives as Cosmetics: A New Fountain of Youth in Skin Aging and Skin Protection

Janjetovic,

Slominski

2024

Cosmetics

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Vitamin D is a natural photoproduct that has many beneficial effects on different organs, including skin. Active forms of vitamin D and its derivatives exert biological effects on skin cells, thus maintaining skin homeostasis. In keratinocytes, they inhibit proliferation and stimulate differentiation, have anti-inflammatory properties, act as antioxidants, inhibit DNA damage and stimulate DNA repair after ultraviolet (UV) exposure. In melanocytes, they also inhibit cell proliferation, inhibit apoptosis and act as antioxidants. In fibroblasts, they inhibit cell proliferation, affect fibrotic processes and collagen production, and promote wound healing and regeneration. On the other hand, skin cells have the ability to activate vitamin D directly. These activities, along with the projected topical application of vitamin D derivatives, are promising for skin care and photo protection and can be used in the prevention or possible reversal of skin aging.

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Section: Skin and Photo-aging 21 The Damaging Effects Of Uv Radiation...mentioning

confidence: 99%

Promising Functions of Novel Vitamin D Derivatives as Cosmetics: A New Fountain of Youth in Skin Aging and Skin Protection

Janjetovic,

Slominski

2024

Cosmetics

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“…Remarkably, the pattern of gene expression of RGCs is largely shaped by several epigenetic controls, including DNA methylation, histone modifications such as H3K4me3 and H3K27me3, and 3D chromatin architecture [119]. Epitranscriptomic changes, such as m 6 A-eRNA methylation and m5C RNA methylation, also control the function and turnover of cell-type-specific transcripts, which, in turn, regulates the temporal pre-patterning of RGCs [119]. DNA methylation patterns have a well-recognized role in NSC proliferation and differentiation and help to establish and maintain the specific identity of neurons, contributing to the diversity of neuronal subtypes in the brain [19,120].…”

Section: Epigenetic Regulation In the Developing And Mature Brainmentioning

confidence: 99%

“…On these premises, researchers have developed a series of so-called epigenetic clocks that provide a molecular measure of aging and can be used to assess the biological age of an individual, which may differ from their chronological age [4]. Understanding the epigenetic changes associated with aging opens avenues for potential interventions to slow down or reverse age-related conditions [5,6]. Starting from this understanding, epigenetic therapies are being explored to rejuvenate tissues and combat age-related diseases [7,8].…”

Section: Introductionmentioning

confidence: 99%

An Overview of the Epigenetic Modifications in the Brain under Normal and Pathological Conditions

Lossi,

Castagna,

Merighi

2024

IJMS

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Epigenetic changes are changes in gene expression that do not involve alterations to the DNA sequence. These changes lead to establishing a so-called epigenetic code that dictates which and when genes are activated, thus orchestrating gene regulation and playing a central role in development, health, and disease. The brain, being mostly formed by cells that do not undergo a renewal process throughout life, is highly prone to the risk of alterations leading to neuronal death and neurodegenerative disorders, mainly at a late age. Here, we review the main epigenetic modifications that have been described in the brain, with particular attention on those related to the onset of developmental anomalies or neurodegenerative conditions and/or occurring in old age. DNA methylation and several types of histone modifications (acetylation, methylation, phosphorylation, ubiquitination, sumoylation, lactylation, and crotonylation) are major players in these processes. They are directly or indirectly involved in the onset of neurodegeneration in Alzheimer’s or Parkinson’s disease. Therefore, this review briefly describes the roles of these epigenetic changes in the mechanisms of brain development, maturation, and aging and some of the most important factors dynamically regulating or contributing to these changes, such as oxidative stress, inflammation, and mitochondrial dysfunction.

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Unfolding the complexity of epigenetics in male reproductive aging: a review of therapeutic implications

Ajayi,

Oyovwi,

Olatinwo

et al. 2024

Mol Biol Rep

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Emerging epigenetic insights into aging mechanisms and interventions

Cited by 7 publications

References 160 publications

Promising Functions of Novel Vitamin D Derivatives as Cosmetics: A New Fountain of Youth in Skin Aging and Skin Protection

Promising Functions of Novel Vitamin D Derivatives as Cosmetics: A New Fountain of Youth in Skin Aging and Skin Protection

An Overview of the Epigenetic Modifications in the Brain under Normal and Pathological Conditions

Unfolding the complexity of epigenetics in male reproductive aging: a review of therapeutic implications

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