Emerging contaminants: Presentations at the 2009 Toxicology and Risk Assessment Conference

Murnyak, George; Vandenberg, John; Yaroschak, Paul; Williams, Larry R.; Prabhakaran, Krishnan; Hinz, John

doi:10.1016/j.taap.2010.10.021

Cited by 22 publications

(14 citation statements)

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“…Our review demonstrates that these contaminants continuously produce emerging and urgent challenges to the soil, water, air, and ecosystems, particularly human health ( Figure 1 ) [ 2 ]. Moreover, new chemical outputs spread and usually exceed the abilities of safety remediation, risk evaluation methods, monitoring techniques, and current preventative factors [ 1 , 2 ]. Given the current conditions, the following several interactive factors should be considered to assess human health effects of pollutant exposure: contaminant concentration, category and properties, scale and level of pollutants, and the hazard intensity generated for health and available resources.…”

Section: Discussionmentioning

confidence: 99%

“…Given the current conditions, the following several interactive factors should be considered to assess human health effects of pollutant exposure: contaminant concentration, category and properties, scale and level of pollutants, and the hazard intensity generated for health and available resources. The elimination of emerging contaminants in the environment and human body depends on future techniques and studies to establish overall remediation theories and methods [ 1 , 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…Emerging contaminants are chemical substances or compounds characterized by a perceived or veridical threat to the environment or human health with a lack of published health criteria. An “emerging” contaminant may also be identified from an unknown source, a new exposure to humans, or a novel detection approach or technology [ 1 , 2 ]. Emerging contaminants include an extensive array of synthetic chemicals in global use, such as perfluorinated compounds, water disinfection byproducts, gasoline additives, pharmaceuticals, man-made nanomaterials, and UV-filters, which are significant for the development of modern society [ 2 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Emerging contaminants include an extensive array of synthetic chemicals in global use, such as perfluorinated compounds, water disinfection byproducts, gasoline additives, pharmaceuticals, man-made nanomaterials, and UV-filters, which are significant for the development of modern society [ 2 – 5 ]. Because of their rapidly increasing use in industry, transport, agriculture, and urbanization, these chemicals are entering the environment at increasing levels as hazardous wastes and nonbiodegradable substances [ 1 , 2 ]. Furthermore, adequate and robust epidemic information on their behavior and fate in the global environment, as well as on human exposure, serum and tissue concentrations, and threats to ecological and human health, have not been well documented [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Overview of Emerging Contaminants and Associated Human Health Effects

Meng

Zhang

Lei

et al. 2015

BioMed Research International

157

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In recent decades, because of significant progress in the analysis and detection of trace pollutants, emerging contaminants have been discovered and quantified in living beings and diverse environmental substances; however, the adverse effects of environmental exposure on the general population are largely unknown. This review summarizes the conclusions of the comprehensive epidemic literature and representative case reports relevant to emerging contaminants and the human body to address concerns about potential harmful health effects in the general population. The most prevalent emerging contaminants include perfluorinated compounds, water disinfection byproducts, gasoline additives, manufactured nanomaterials, human and veterinary pharmaceuticals, and UV-filters. Rare but statistically meaningful connections have been reported for a number of contaminants and cancer and reproductive risks. Because of contradictions in the outcomes of some investigations and the limited number of articles, no significant conclusions regarding the relationship between adverse effects on humans and extents of exposure can be drawn at this time. Here, we report that the current evidence is not conclusive and comprehensive and suggest prospective cohort studies in the future to evaluate the associations between human health outcomes and emerging environmental contaminants.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Overview of Emerging Contaminants and Associated Human Health Effects

Meng

Zhang

Lei

et al. 2015

BioMed Research International

157

View full text Add to dashboard Cite

show abstract

“…As they possess chemical structures similar to natural hormones (Diamanti-Kandarakis et al, 2009), EDs are able to bind and activate many receptors, including nuclear hormone receptors (Li et al, 2015, Zhang et al, 2017a, and disrupt the endocrine system . Since US laws do not obligate the chemical-manufacturing corporations to test new chemicals prior to releasing them in consumer products, the burden is on the scientific community to assess the environmental and health impacts of these chemicals (Murnyak et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Systems analysis of the liver transcriptome in adult male zebrafish exposed to the non-ionic surfactant nonylphenol

Huff

Silveira

Hazard

et al. 2019

General and Comparative Endocrinology

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Nonylphenol (NP) arises from the environmental degradation of nonylphenol ethoxylates. It is a ubiquitous environmental contaminant and has been detected at levels up to 167 nM in rivers in the United States. NP is an endocrine disruptor (ED) that can act as an agonist for estrogen receptors. The Adverse Outcome Pathway (AOP) framework defines an adverse outcome as the causal result of a series of molecular initiating events (MIEs) and key events (KEs) that lead to altered phenotypes. This study examined the liver transcriptome after a 21 day exposure to NP and 17β-estradiol (E2) by exploiting the zebrafish (Danio rerio) as a systems toxicology model. The goal of this study was to tease out non-estrogenic genomic signatures associated with NP exposure using DNA microarray and RNA sequencing. Our experimental design included E2 as a positive and potent estrogenic control in order to effectively compare and contrast the 2 compounds. This approach allowed us to identify hepatic transcriptomic perturbations that could serve as MIEs for adverse health outcomes in response to NP. Our results revealed that exposure to NP was associated with differential expression (DE) of genes associated with the development of steatosis, disruption of metabolism, altered immune response, and metabolism of reactive oxygen species, further highlighting NP as a chemical of emerging concern (CEC).

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Metal ions limit or enhance environmental DNA detectability in marine sediments

Dumoulin,

Chevrinais,

St‐Louis

et al. 2024

Environmental DNA

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Natural matrices affect environmental DNA (eDNA) detections. Effects of matrix‐eluted compounds on the polymerase chain reaction (PCR) step have been the focus of most inhibition studies. Factors affecting eDNA detections in a typical laboratory workflow, i.e., DNA extraction and PCR steps, are mostly unknown. Here, we assessed the effect of four metal ions (Ca2+, Fe3+, Mn2+, Cu2+) present in marine sediments on DNA detectability for both the extraction and the PCR detection steps. A single metal ion and exogenous DNA were added to marine sediments treated chemically to remove inhibitors. Our results showed that natural concentrations of calcium, iron, and manganese ions in surface marine sediments can impede completely DNA detections. Alternatively, copper ions added to the matrix increased DNA detectability by 7.7%. We also observed bimodal inhibitory effects of calcium and iron ions on DNA detectability, suggesting that the extraction and the PCR steps are both affected. Our findings highlight new limitations of eDNA detections. Avenues to optimize eDNA detection protocols applicable to multiple matrices are discussed.

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Emerging contaminants: Presentations at the 2009 Toxicology and Risk Assessment Conference

Cited by 22 publications

References 1 publication

Overview of Emerging Contaminants and Associated Human Health Effects

Overview of Emerging Contaminants and Associated Human Health Effects

Systems analysis of the liver transcriptome in adult male zebrafish exposed to the non-ionic surfactant nonylphenol

Metal ions limit or enhance environmental DNA detectability in marine sediments

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