Emerging clinical and therapeutic applications of Nigella sativa in gastroenterology

Kapoor, Shailendra

doi:10.3748/wjg.15.2170

Cited by 32 publications

(17 citation statements)

References 14 publications

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“…N. sativa is not toxic to normal cells though TQ suppresses proliferation of tumor cells [34]. N. sativa may be of therapeutic benefit in diabetic individuals and those with glucose intolerance as it accentuates glucose-induced secretion of insulin besides having a negative impact on glucose absorption from the intestinal mucosa [35].…”

Section: Review and Discussionmentioning

confidence: 99%

Antidiabetic Properties of a Spice Plant Nigella sativa

Mathur

2011

J Endocrinol Metab

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Seeds of Nigella sativa (black cumin/kalonji) used in pickles as spice, have also been traditionally used in treatment of many diseases including diabetes and hypertension. Among many activities exhibited by N. sativa and its constituents in animal experiments, antidiabetic property is most important. Thymoquinone (TQ), a volatile oil, is one of its active constituents but antidiabetic activity has also been shown by its aqueous extract and defatted extract. N. sativa may be beneficial in diabetic individuals and those with glucose intolerance as it reduces appetite, glucose absorption in intestine, hepatic gluconeogenesis, blood glucose level, cholesterol, triglycerides, body weight and simulates glucose induced secretion of insulin from beta-cells in pancreas; improves glucose tolerance as efficiently as metformin; yet it has not shown significant adverse effects and has very low toxicity. In streptozotocin (STZ) induced diabetic rats it causes gradual partial regeneration of pancreatic beta-cells, increases the lowered serum insulin concentrations and decreases the elevated serum glucose. N. sativa has antioxidant activity and protective role of TQ against development of type I diabetes may be via NO inhibitory pathway. It also exerts an insulin-sensitizing action in hepatocytes. Seeds of N. sativa have been safely consumed by human patients in many clinical trials which however were not aimed to assess its antidiabetic activity. In future clinical studies may show potential of N. sativa, its constituents or their synthetic analogues, in prevention and control of diabetes.

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Section: Review and Discussionmentioning

confidence: 99%

Antidiabetic Properties of a Spice Plant Nigella sativa

Mathur

2011

J Endocrinol Metab

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“…Results suggested that N. sativa treatment protects the rat liver against hepatic ischemia reperfusion injury [86] . N. sativa administration protects hepatic tissue from deleterious effects of toxic metals such as lead, and attenuates hepatic lipid peroxidation following exposure to chemicals such as carbon tetrachloride [52] . Cadmium (Cd ++ ) causes alteration of the cellular homeostasis and oxidative damage.…”

Section: Hepato-protective Activitymentioning

confidence: 99%

“…N. sativa oil has a significant activity in diabetic and dyslipidemic patients [51] . N. sativa is of immense therapeutic benefit in diabetic individuals and those with glucose intolerance as it accentuates glucose-induced secretion of insulin besides having a negative impact on glucose absorption from the intestinal mucosa [52] . The effects of the TQ in STZ-induced diabetes in rats were investigated.…”

Section: Antidiabetic Activitymentioning

confidence: 99%

A review on therapeutic potential of Nigella sativa: A miracle herb

Ahmad

Husain

Mujeeb

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

1,002

733

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“…It was reported that, thymoquinone(TQ) has many medicinal properties like; anti-oxidant (Meral et al, 2001;Shalaby and khater, 2007;Zegarac et al, 2009 ), anti-inflammatory (Hajhashemi et al, 2004), anti-tumor (Banerjee et al, 2010), analgesic and other properties (Kaleem et al, 2006;Bhatti et al, 2009). On the other side, Kapoor ( 2009) proved that TQ protects hepatic tissue from deleterious effects of toxic metals such as lead, and attenuates hepatic lipid peroxidation following exposure to chemicals such as carbon tetrachloride. However, in spite of the large number of the antioxidant and hepatoprotective studies carried out worldwide on N. sativa oil and TQ, scrutiny of published articles (Al-Ghamdi, 2003) showed that there is a need to investigate the .…”

Section: Introductionmentioning

confidence: 99%

Nigella sativa seeds protect against hepatotoxicity and dyslipidemia induced by carbon tetrachloride in mice

Essawy¹

2012

J. App. Pharm. Sci.

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The present study was conducted to evaluate the hepatoprotective effects of aqueous seed extract of Nigella sativa (black seed) on carbon tetrachloride (CCl4) induced liver damage in Swiss albino mice. CCl4 (1.9 ml/kg b.w.) was given orally every other day for three weeks. Aqueous suspension of N. sativa seeds (50 mg/kg b.w.) was given orally every other day alternated with CCl4 for three weeks. Blood was collected for the assessment of serum marker enzymes ( ALT, AST ,ALP and LDH) and lipid profile(triglycerides, total cholesterol, HDL and total lipids), while liver tissue was used for histopathological assessment. Serum levels of liver enzymes and lipid contents were significantly increased in animals treated with CCL4 as compared to control. Histopathological observations, also revealed severe damage in the structure of liver tissue in animals intoxicated with CCL4. Combined treatment of CCL4-exposed animals with N.sativa showed marked improvement in both biochemical and histopathological findings. Only LDH did not affect by N. sativa administration.

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Emerging clinical and therapeutic applications of Nigella sativa in gastroenterology

Cited by 32 publications

References 14 publications

Antidiabetic Properties of a Spice Plant Nigella sativa

Antidiabetic Properties of a Spice Plant Nigella sativa

A review on therapeutic potential of Nigella sativa: A miracle herb

Nigella sativa seeds protect against hepatotoxicity and dyslipidemia induced by carbon tetrachloride in mice

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